DEVELOPMENT OF HYBRID-TYPE ARTIFICIAL LIGAMENT COMPOSED OF BIOABSORBABLE SYNTHETIC FIBERS AND HUMAN COLLAGEN BIBER BUNDLES

1.自然愈合现象发生在植入骨隧道内的混合型人工韧带（Hyb-AL）的人源性胶原纤维束部分中。该部分与体壁结合，具有纤维结缔组织。3周时该部分的结合强度与自体骨腱移植物相当，6周时与自体骨腱移植物相当.在使用由直径为0.01 mm的生物可吸收聚对二氧环己酮纤维组成的Hyb-AL进行ACL重建时，在骨隧道内发生的异物反应更为显著。随后，与使用0.6 mm聚对二氧环己酮（PD）纤维的Hyb-AL相比，隧道扩大到更大程度。在拉伸测试中，这两种类型的人工韧带之间的最大载荷没有显著差异。生物可吸收合成纤维的直径和体积显著影响Hyb-AL的骨内愈合。含聚乳糖的混合型人工韧带 ...更多信息 e（PG）纤维通常从隧道中拉出。在拔出试验后的大体观察中，PG纤维总是熔化的。这些结果与其他人工韧带的结果截然不同。PG纤维不适合作为Hyb-AL的组分。在涉及可吸收聚乳酸（PL）纤维、PD纤维和不可吸收聚酯（PE）纤维的Hyb-AL之间，失效模式和最大载荷无显著差异。涉及PL纤维或PD纤维的Hyb-AL预计至少在6周内具有与涉及PE纤维的Hyb-AL相同的能力。在PL纤维和PE纤维周围，骨隧道内新骨形成丰富，使隧道变窄.基于这些结果，认为由生物可吸收PL纤维和人源性胶原纤维束组成的混合型人工韧带可用于临床应用。最后，我们设计了两种类型的Hyb-AL，用于ACL和PCL重建手术的临床应用。我们还开发了植入这些韧带的外科手术。少

1. The natural healing phenomenon occurs in the human-derived collagen fiber bundle portion of the hybrid-type artificial ligament (Hyb-AL) which was implanted within the bone tunnel. This part was bonded to the body wall with fibrous connective tissue. The bonding strength of this part was inferiorto that of the bone tendon autograft at 3 weeks, but equivalent at 6 weeks.2. In ACL reconstruction using the Hyb-AL composed of bioabsorbable Polydioxanone fibers having a diameter of 0.01 mm, foreign body reaction occurred More significantly within the bone tunnel. Subsequently, the tunnel was enlarged to a greater degree in comparison with the Hyb-AL using 0.6-mm Polydioxanone (PD) fibers. In tensile testing, there were no significant differences in the maximum load between these two types of artificial ligament. The diameter and the volume of bioabsorbable synthetic fibers significantly affect intraosseous healing of the Hyb-AL.3. The hybrid-type artificial ligament involving Polyglactin … More e (PG) fibers was commonly pulled out from the tunnel. In gross observation of the specimens after pull-out testing, the PG fibers were always melt. These results were extremely different from those in the other artificial ligaments. The PG fiber is not appropriate as a component of the Hyb-AL.4. There were no significant differences in the failure mode and the maximum load among the Hyb-ALs involving absorbable Polylactic acid (PL) fibers, PD fibers, and non-absorbable Polyester (PE) fibers. The Hyb-AL involving PL fibers or PD fibers is expected to have the same ability as that involving PE fibers, at least, for 6 weeks.5. Around PL fibers and PE fibers, new bone formation richly occurred within the bone tunnel so that the tunnel became narrow.6. Based on these results, the hybrid-type artificial ligament composed of bioabsorbable PL fibers and human-derived collagen fiber bundles is considered to useful for clinical application.7. Finally, we designed 2 types of Hyb-AL for clinical use in ACL- and PCL-reconstruction surgeries. We also developed surgical procedures to implant these ligaments. Less