Analyses on a molecular mechanism of spontaneous articular cartilage regeneration induced in vivo by double-network gel
Analyses on a molecular mechanism of spontaneous articular cartilage regeneration induced in vivo by double-network gel
批准号:
20240045
负责人:
YASUDA Kazunori
金额:
$32.36万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
(1) We clarified genetic characteristics of the articular cartilage spontaneously regenerated by double-network (DN) gel, using microarray. (2) We found that PAMPS, a component of the DN gel, has an ability that can induces the spontaneous articular cartilage regeneration. (3) We observed marker genes in a chondrogenic differentiation process, using multi-colored bioluminescence probes. We discovered a synchronized oscillation phenomenon of cell metabolism in prechondrogenic condensation. (4) We developed the transgenic bioluminescence mouse to be used for in vivo imaging. (5) These results provided important information to clarify a comprehensive mechanism of the spontaneous cartilage regeneration phenomenon.
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DOI:
10.1177/0363546509350749
发表时间:
2010-04-01
期刊:
AMERICAN JOURNAL OF SPORTS MEDICINE
影响因子:
4.8
作者:
[Kobayashi, Yasukazu, Yasuda, Kazunori, Tohyama, Harukazu]
通讯作者:
Tohyama, Harukazu
Implantation of comminuted autogenous meniscus tissue into a large meniscus defect enhances spontaneous in situ regeneration of the meniscus an experimental study
将粉碎的自体半月板组织植入到大的半月板缺损中可增强半月板的自发原位再生实验研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kobayashi Y, Yasuda K, Kondo E, Katsura T, Kumura M]
通讯作者:
Kumura M
DOI:
10.2144/000113419
发表时间:
2010-06-01
期刊:
BIOTECHNIQUES
影响因子:
2.7
作者:
[Kwon, HyuckJoon, Enomoto, Toshiteru, Ohmiya, Yoshihiro]
通讯作者:
Ohmiya, Yoshihiro
DOI:
10.1039/b916581a
发表时间:
2009-01-01
期刊:
CHEMICAL COMMUNICATIONS
影响因子:
4.9
作者:
[Liang, Songmiao, Yu, Qiu Ming, Gong, Jian Ping]
通讯作者:
Gong, Jian Ping
Local administration of synovium-derived fibroblasts cultured in TGF-betal-supple mented medium inhibits natural reduction of the structural properties of the tendon autograft after ACL reconstruction : A sheep model study
局部施用在添加 TGF-β 的培养基中培养的滑膜来源的成纤维细胞可抑制 ACL 重建后自体肌腱结构特性的自然降低:一项绵羊模型研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kondo E, Hayashi R, Katsura T, Azuma C, Tohyama H, Yasuda K]
通讯作者:
Yasuda K
共 54 条
Flow analysis in a nanoscale space using scanning electron microscope and its development to soft matter flow
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批准号:25630053
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2013
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负责人:YASUDA Kazunori
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依托单位:
Clarification of signal transmission mechanism in mesenchymal cells during spontaneous cartilage regeneration induced by multi-functional synthetic gel
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批准号:23240070
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.28万
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财政年份:2011
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负责人:YASUDA Kazunori
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依托单位:
Visualization and analysis of soft materials in nanoscale flow for Development of nanocomposites
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批准号:23656411
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.25万
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财政年份:2011
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负责人:YASUDA Kazunori
-
依托单位:
Visualization and analysis of flow-induced structure in micro flow for production of nanofiber composite
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批准号:20560641
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2008
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负责人:YASUDA Kazunori
-
依托单位:
Analysis of flow-induced structure of polynieric fluid in a miatchannel for processing of nano composite materials
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批准号:18560667
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.2万
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财政年份:2006
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负责人:YASUDA Kazunori
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依托单位:
Clarification of Mechanism of the Tendon/Ligament Matrix Remodeling Induced by Various Mesenchymal Cells and Its Molecular Control
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批准号:16390425
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.83万
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财政年份:2004
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负责人:YASUDA Kazunori
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依托单位:
Velocity measurement of velocity profile of complex fluids through a microchannel and the effect of the channel size on the flow pattern
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批准号:15560141
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2003
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负责人:YASUDA Kazunori
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依托单位:
Visualization and numerical analysis of fiber orientation on weld line in processing for fiber-reinforced composite materials
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批准号:13650747
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:2001
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负责人:YASUDA Kazunori
-
依托单位:
Integrated Analyses on adaptation and control mechanisms in remodeling of the extracellular matrix in the in situ frozen-thawed anterior cruciate ligament
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批准号:12470299
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.15万
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财政年份:2000
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负责人:YASUDA Kazunori
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依托单位:
DEVELOPMENT OF HYBRID-TYPE ARTIFICIAL LIGAMENT COMPOSED OF BIOABSORBABLE SYNTHETIC FIBERS AND HUMAN COLLAGEN BIBER BUNDLES
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批准号:10558124
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.36万
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财政年份:1998
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负责人:YASUDA Kazunori
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依托单位:
A biomechanical study on differences in the effect of stress deprivation on the in frozen extensor and flexor tendons.
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批准号:08671629
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1996
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负责人:YASUDA Kazunori
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依托单位:
Development and evaluation of durable hybrid-type artificial ligament composed of high molecular synthetic fibers and human collagen fiber bundles
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批准号:07558118
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$8.45万
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财政年份:1995
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负责人:YASUDA Kazunori
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依托单位:
Ultrastructural analyzes on mechanism of effects of stress shielding on the mechanical properties of the in situ frozen patellar tendon.
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批准号:06671433
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.54万
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财政年份:1994
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负责人:YASUDA Kazunori
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依托单位:
海外基金