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Analyses on a molecular mechanism of spontaneous articular cartilage regeneration induced in vivo by double-network gel

Analyses on a molecular mechanism of spontaneous articular cartilage regeneration induced in vivo by double-network gel
双网络凝胶体内诱导关节软骨自发再生的分子机制分析
批准号:
20240045
负责人:
YASUDA Kazunori
金额:
$32.36万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
(1) We clarified genetic characteristics of the articular cartilage spontaneously regenerated by double-network (DN) gel, using microarray. (2) We found that PAMPS, a component of the DN gel, has an ability that can induces the spontaneous articular cartilage regeneration. (3) We observed marker genes in a chondrogenic differentiation process, using multi-colored bioluminescence probes. We discovered a synchronized oscillation phenomenon of cell metabolism in prechondrogenic condensation. (4) We developed the transgenic bioluminescence mouse to be used for in vivo imaging. (5) These results provided important information to clarify a comprehensive mechanism of the spontaneous cartilage regeneration phenomenon.
期刊论文(67)
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会议论文
DOI: 10.1177/0363546509350749
发表时间: 2010-04-01
期刊: AMERICAN JOURNAL OF SPORTS MEDICINE
影响因子: 4.8
作者: [Kobayashi, Yasukazu, Yasuda, Kazunori, Tohyama, Harukazu]
通讯作者: Tohyama, Harukazu
Implantation of comminuted autogenous meniscus tissue into a large meniscus defect enhances spontaneous in situ regeneration of the meniscus an experimental study
将粉碎的自体半月板组织植入到大的半月板缺损中可增强半月板的自发原位再生实验研究
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Kobayashi Y, Yasuda K, Kondo E, Katsura T, Kumura M]
通讯作者: Kumura M
DOI: 10.2144/000113419
发表时间: 2010-06-01
期刊: BIOTECHNIQUES
影响因子: 2.7
作者: [Kwon, HyuckJoon, Enomoto, Toshiteru, Ohmiya, Yoshihiro]
通讯作者: Ohmiya, Yoshihiro
DOI: 10.1039/b916581a
发表时间: 2009-01-01
期刊: CHEMICAL COMMUNICATIONS
影响因子: 4.9
作者: [Liang, Songmiao, Yu, Qiu Ming, Gong, Jian Ping]
通讯作者: Gong, Jian Ping
54
    Flow analysis in a nanoscale space using scanning electron microscope and its development to soft matter flow
    • 批准号:
      25630053
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2013
    • 负责人:
      YASUDA Kazunori
    • 依托单位:
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    • 批准号:
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    • 项目类别:
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    • 资助金额:
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    • 财政年份:
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    • 负责人:
      YASUDA Kazunori
    • 依托单位:
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    • 批准号:
      23656411
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.25万
    • 财政年份:
      2011
    • 负责人:
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    • 项目类别:
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    • 资助金额:
      $3.24万
    • 财政年份:
      2008
    • 负责人:
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    • 依托单位:
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