Studies on human health assesement based upon a dose-response relationship between human and harmful substanus in the emvironment

本研究旨在建立基于二恶英与人体之间的剂量-反应关系的人体健康评估。大鼠肝癌致癌水平为24 ng/g。此外，对大鼠有一定影响的二恶英暴露水平为10 ng/kg/d。二恶英的水平在人类身上没有达到这两个值。根据建立的剂量-反应关系，在接触高浓度二恶英的人群中，所有癌症、肺癌和软组织肉瘤的发病率与本底发病率没有差别。因此，本研究的结果表明，即使在接触高水平二恶英的人群中，目前也没有检测到二恶英的致癌作用。本研究建立的方法学可能为二恶英的人体健康评估提供一种有效的工具。

The present study was designed to establish human health assessment based on a dose-response relationship between dioxin and humans. The level of dioxin in the lever causing liver cancer was 24 ng/g in rats. Also, the exposure level of dioxin leading to some influence was 10 ng/kg/day in rats. The level of dioxin did not reach the two values in humans. The incidence of all cancers, lung cancer and sarcoma derived from soft tissues was not defferenciated from the background incidence when examined in the group exposed to high levels of dioxin using the dose-response relationship established. Thus, the rsults of the present study demonstrate that the carcinogenicity of dioxin is not at present detected even in the group exposed to high levels of dioxin. The methodology established in the present study may be an available tool in human health assessment of dioxin.