Studies on human health assesement based upon a dose-response relationship between human and harmful substanus in the emvironment

基于人体与环境有害物质剂量反应关系的人体健康评估研究

• 批准号: 11470098
• 负责人: WADA Osamu
• 金额: $ 9.79万
• 依托单位: Saitama Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470098/
• 关键词: Dioxin; Dose-response relationship; health assessment; 発癌; ベンツピレン; 量反応関係

The present study was designed to establish human health assessment based on a dose-response relationship between dioxin and humans. The level of dioxin in the lever causing liver cancer was 24 ng/g in rats. Also, the exposure level of dioxin leading to some influence was 10 ng/kg/day in rats. The level of dioxin did not reach the two values in humans. The incidence of all cancers, lung cancer and sarcoma derived from soft tissues was not defferenciated from the background incidence when examined in the group exposed to high levels of dioxin using the dose-response relationship established. Thus, the rsults of the present study demonstrate that the carcinogenicity of dioxin is not at present detected even in the group exposed to high levels of dioxin. The methodology established in the present study may be an available tool in human health assessment of dioxin.

本研究旨在根据二恶英与人类之间的剂量反应关系建立人类健康评估。大鼠体内引起肝癌的二恶英含量为24纳克/克。此外，对大鼠造成一定影响的二恶英暴露水平为10 ng/kg/天。二恶英的含量没有达到人体的两个值。当使用建立的剂量反应关系对暴露于高水平二恶英的组进行检查时，所有源自软组织的癌症、肺癌和肉瘤的发病率与背景发病率没有差异。因此，本研究的结果表明，即使在暴露于高浓度二恶英的人群中，目前也未检测到二恶英的致癌性。本研究建立的方法可能是二恶英人类健康评估的可用工具。

项目成果

O. Wada: "Dioxin problem in occupational health"Occupational herlth Review. 12(1). 1-51 (1999)

O. Wada：“职业健康中的二恶英问题”职业健康评论。

O.Wada: "Enhanced expression of vsmNOS mRNA in glomeruli from rats with unilateral areteral obstruction"Kidney Int. 57. 1502-1511 (2000)

O.Wada：“单侧动脉阻塞大鼠肾小球中 vsmNOS mRNA 的表达增强”Kidney Int。

H. Yanagisawa: "Effects of zinc deficiency on the expression of preproendothelin-1 mRNA in glomemli of rats with unilateral ureteral obstruction"Trace Nutrients Res. 16. 177-180 (1999)

H. Yanagisawa：“缺锌对单侧输尿管梗阻大鼠肾小球中前内皮素-1 mRNA 表达的影响”微量营养研究。

H.Yanagisawa: "Inhibitory effects of L-arginine treatment on the progression of GeO_2-induced tubulointerstitial nephropathy"Trace Nutrients Res. 17. 47-52 (2000)

H.Yanagisawa：“L-精氨酸治疗对GeO_2诱导的肾小管间质性肾病进展的抑制作用”Trace Nutrients Res。

H. Yanagisawa: "L-Arginine treatment suppresses macrophage infiltration and inhibits TGF-β_1 and collagen type IU expression in tubulointerstitial nephropathy caused by germanium dioxide"Kidney Int. (in press).

H. Yanagisawa：“L-精氨酸治疗可抑制二氧化锗引起的肾小管间质性肾病中的巨噬细胞浸润并抑制 TGF-β_1 和胶原型 IU 的表达”Kidney Int。