Construction of Evaluating system of serum markers for Gastric Cancer.

胃癌血清标志物评价体系的构建。

• 批准号: 05304029
• 负责人: WADA Osamu
• 金额: $ 8万
• 依托单位: UNIVERSITY OF TOKYO
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05304029/
• 关键词: Gastric cancer; Helicobacter pylori; Optimum cut off; Serum pepsinogen; ROC curve; Sensitivity; Specificity; Odds ratio; 発ガン; ヘリコバクター抗体; 生活習慣; 既往歴; 自記式アンケート

Until the end of 1994,735 gastric cancer cases and 1005 controls were collected. As for the subjects, serum pepsinogen I,II and serum anti-Helicobacter pylori IgG antibody were measured. The residual sera habe been stored at -80ﾟC.Optimum cut off values of serum pepsinogen for diagnosis of gastric cancer were searched for by ROC (Receiver Operator Characteristics) curve regarding 6 age-sex groups.<<table>>The sensitivity and specificity were negatively related to age, but for no age-sex group, adequate value for practical use in mass-screening was obtained. Some of the patients in the analysis were incurable advanced cancer and precise analysis should be done limiting the patients to those with curable cancer in order to evaluate serum pepsinogen finally. Optimum sensitivity and specificity when two or more markers are used together should also be searched for.Odds ratios (OR) for the association between gastric cancer and seropositivity of anti-Helicobacter antibody were calculated regarding 5 age groups. For those aged 20-29 years, OR was 23.1, for 30-39 it was 11.0, for 40-49 it was 9.6, for 50-59 it was 3.3 and for 60-69 it was 1.6.

截至1994年底，共收集胃癌病例735例，对照1005例。对于受试者，测量血清胃蛋白酶原I、II和血清抗幽门螺杆菌IgG抗体。残留血清保存于-80°C。通过ROC（接受者操作特征）曲线寻找6个年龄-性别组的血清胃蛋白酶原诊断胃癌的最佳截止值。<<表>>敏感性和特异性与年龄呈负相关，但对于无年龄-性别组，在大规模筛查中获得了足够的实用价值。分析中的一些患者是无法治愈的晚期癌症，应进行精确分析，将患者限制为可治愈的癌症患者，以便最终评估血清胃蛋白酶原。还应寻求同时使用两种或多种标记物时的最佳敏感性和特异性。针对 5 个年龄组计算了胃癌与抗螺杆菌抗体血清阳性之间关联的比值比 (OR)。对于20-29岁的人，OR为23.1，30-39岁的OR为11.0，40-49岁的OR为9.6，50-59岁的OR为3.3，60-69岁的OR为1.6。