Risk assessment techniques for chemical substances in the environment

环境中化学物质风险评估技术

• 批准号: 08457112
• 负责人: WADA Osamu
• 金额: $ 4.67万
• 依托单位: Saitama Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457112/
• 关键词: Chemical Substance; Pharmacokinetic model; Risk assessment; CAT assay

The present study was designed to develop the new risk assessment system of the chemical substances in the environment by means of the CAT assay and the pharmacokinetic model consisting og six components such as blood-rich organs(brain, adrenal gland and bone marrow), blood-poor organs(hone and adipose tissue), kidney, liver and intestine. The CAT assay was available because of utilizing human cells and providing the valuable information on the mechanisms responsible for cell toxicity and carcinogenesis. The pharmacokinetic model was also considered to be an useful method to presume the concentration of drugs in the target organ and to evaluate the toxicity of unknown chemical substances.

本研究旨在通过CAT法和富血器官（脑、肾上腺、骨髓）、贫血器官（骨骼、脂肪组织）、肾、肝、肠六部分组成的药代动力学模型，建立新的环境中化学物质风险评估体系。CAT试验之所以可行，是因为它利用了人类细胞，并提供了有关细胞毒性和致癌机制的宝贵信息。药代动力学模型也被认为是推测靶器官内药物浓度和评价未知化学物质毒性的有效方法。

项目成果

和田攻: "産業化学物質の有害性評価" 産業医学レビュー. 8(4). 171-181 (1996)

Osamu Wada：“工业化学品的危害评估”工业医学评论 8(4) (1996)。

H.Yanagisawa and O.Wada: "Ureteral obstruction enhances eicosanoid production in cortical and medullary tubules of rat kidneys." Kidney Blood Press.Res.20. 398-405 (1997)

H.Yanagisawa 和 O.Wada：“输尿管阻塞增强了大鼠肾脏皮质和髓质小管中类二十烷酸的产生。”

H.Yanagisawa, M.Nodera and O.Wada.: "Effects of zinc deficiency on the expression of endothelin-1 in glomeruli of rats with unilateral ureteral obstruction." Trace Nutrients Res.15. 65-68 (1998)

H.Yanagisawa、M.Nodera 和 O.Wada.：“缺锌对单侧输尿管梗阻大鼠肾小球内皮素-1 表达的影响”。

H.Yanagisawa, and O.Wada: "Altered expression of endothelin-1 and endothelial nitric oxide synthase in the juxtaglomerular apparatus of rats with HgCl_2-induced acute renal failure." Toxicol.Let.,. 98. 181-188 (1998)

H.Yanagisawa 和 O.Wada：“HgCl_2 诱导的急性肾衰竭大鼠肾小球旁器官中内皮素-1 和内皮一氧化氮合酶的表达发生改变。”

H.Yanagisawa, M.Nodera, N.Kurihara and O.Wada.: "Altered expression of endothelin-1 and endothelial nitric oxide synthase in the juxtaglomerular apparatus of rats with HgCl_2-induced acute renal failure." Toxicol.Let.98. 181-188 (1998)

H.Yanagisawa、M.Nodera、N.Kurihara 和 O.Wada.：“HgCl_2 诱导的急性肾衰竭大鼠肾小球旁装​​置中内皮素-1 和内皮一氧化氮合酶的表达发生改变。”