Risk assessment techniques for chemical substances in the environment
Risk assessment techniques for chemical substances in the environment
批准号:
08457112
负责人:
WADA Osamu
金额:
$4.67万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
1996
资助国家:
日本
项目状态:
已结题
起止时间:
1996 至 1998
中文摘要
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英文摘要
The present study was designed to develop the new risk assessment system of the chemical substances in the environment by means of the CAT assay and the pharmacokinetic model consisting og six components such as blood-rich organs(brain, adrenal gland and bone marrow), blood-poor organs(hone and adipose tissue), kidney, liver and intestine. The CAT assay was available because of utilizing human cells and providing the valuable information on the mechanisms responsible for cell toxicity and carcinogenesis. The pharmacokinetic model was also considered to be an useful method to presume the concentration of drugs in the target organ and to evaluate the toxicity of unknown chemical substances.
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和田攻: "産業化学物質の有害性評価" 産業医学レビュー. 8(4). 171-181 (1996)
Osamu Wada:“工业化学品的危害评估”工业医学评论 8(4) (1996)。
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H.Yanagisawa and O.Wada: "Ureteral obstruction enhances eicosanoid production in cortical and medullary tubules of rat kidneys." Kidney Blood Press.Res.20. 398-405 (1997)
H.Yanagisawa 和 O.Wada:“输尿管阻塞增强了大鼠肾脏皮质和髓质小管中类二十烷酸的产生。”
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H.Yanagisawa, M.Nodera and O.Wada.: "Effects of zinc deficiency on the expression of endothelin-1 in glomeruli of rats with unilateral ureteral obstruction." Trace Nutrients Res.15. 65-68 (1998)
H.Yanagisawa、M.Nodera 和 O.Wada.:“缺锌对单侧输尿管梗阻大鼠肾小球内皮素-1 表达的影响”。
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H.Yanagisawa, and O.Wada: "Altered expression of endothelin-1 and endothelial nitric oxide synthase in the juxtaglomerular apparatus of rats with HgCl_2-induced acute renal failure." Toxicol.Let.,. 98. 181-188 (1998)
H.Yanagisawa 和 O.Wada:“HgCl_2 诱导的急性肾衰竭大鼠肾小球旁器官中内皮素-1 和内皮一氧化氮合酶的表达发生改变。”
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通讯作者:
H.Yanagisawa, M.Nodera, N.Kurihara and O.Wada.: "Altered expression of endothelin-1 and endothelial nitric oxide synthase in the juxtaglomerular apparatus of rats with HgCl_2-induced acute renal failure." Toxicol.Let.98. 181-188 (1998)
H.Yanagisawa、M.Nodera、N.Kurihara 和 O.Wada.:“HgCl_2 诱导的急性肾衰竭大鼠肾小球旁装置中内皮素-1 和内皮一氧化氮合酶的表达发生改变。”
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共 16 条
Vertically integrated ultrafast optical modulation devices using ultrahigh density quantum dots
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批准号:18206034
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$27.62万
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财政年份:2006
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负责人:WADA Osamu
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依托单位:
Multi-parameter controlled quantum dots and its application to ultrafast optical functional devices
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Study of local spread of the stage entertainments in the Edo period
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财政年份:2004
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Simultaneous Realization of Ultrafast and High-Nonlinearity Optical Response Characteristics by Shape-Controlled Quantum Dots
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批准号:14350167
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.19万
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财政年份:2002
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负责人:WADA Osamu
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依托单位:
Studies on human health assesement based upon a dose-response relationship between human and harmful substanus in the emvironment
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.79万
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负责人:WADA Osamu
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REEVALUATION OF TRACE ELEMENTS-DEFICIENCY
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.06万
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财政年份:1997
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负责人:WADA Osamu
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依托单位:
Mechanisms responsible for the progression of GeO_2-induced nephropathy
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批准号:08307005
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$9.73万
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财政年份:1996
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负责人:WADA Osamu
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Effects of an essential fatty acid defficiency diet on the progrction of acute renal failu
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资助金额:$22.85万
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财政年份:1994
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负责人:WADA Osamu
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Construction of Evaluating system of serum markers for Gastric Cancer.
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批准号:05304029
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$8.0万
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财政年份:1993
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负责人:WADA Osamu
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依托单位:
Effects of carcinogenic amino-gamma-carbolines on the cell toxicity
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批准号:03454201
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项目类别:Grant-in-Aid for General Scientific Research (B)
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财政年份:1991
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负责人:WADA Osamu
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Estimation of Serum Pepsinogens as a New Marker of Gastric Cancer in Young Men
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批准号:01870028
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$3.2万
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财政年份:1989
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负责人:WADA Osamu
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依托单位:
Eco-biotoxicology of Newly Developed Semiconductor Metals.
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批准号:63304038
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$10.62万
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财政年份:1988
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依托单位:
Metabolism of Carcinogenic Heterocyclic Amines in Foods and Establishment of Exposure Level Monitor for these Carcinogens in Humans.
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财政年份:1988
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依托单位:
Immuno-toxicity of metals and its evaluation
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批准号:61304040
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项目类别:Grant-in-Aid for Co-operative Research (A)
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财政年份:1986
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负责人:WADA Osamu
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依托单位:
Low-molecular-chromium, or nickel-binding substances from liver or milk of animals and their biological functions, especially in relation to detoxication and carcinogenesis of metals.
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批准号:60440039
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$5.57万
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财政年份:1985
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负责人:WADA Osamu
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依托单位:
海外基金