Inhibitory factors of central myelin formation-on the basis of comparative and developmental study on the lemma cribrosa sclerae of the optic nerve

中央髓鞘形成的抑制因素——基于视神经巩膜外稃的比较与发育研究

基本信息

  • 批准号:
    14370001
  • 负责人:
  • 金额:
    $ 3.65万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2002
  • 资助国家:
    日本
  • 起止时间:
    2002 至 2003
  • 项目状态:
    已结题

项目摘要

In the mouse optic nerve, the optic nerve fiber layer in the retina, the optic papilla and the lamina cribrosa sclerae (LCS) just after penetrating the eyeball failed to generate myelin, whereas the optic nerve proper in the orbit was occupied by myelinated nerve fibers. The present study investigated development of the architecture of LCS, where the axons develop from unmyelinated to myelinated type, to elucidate how the initial part of axons was unmyelinated. At the LCS of the adult optic nerve, well developed astrocytes densely formed a cytoplasmic mesh-like frame through which unmyelinated fibers passed. The astrocytes here contained numerous and densely packed intermediate glial filaments and cell organelles. This framework formed by astrocytes appeared to be completed between 7 and 14 postnatal days before oligodendrocyte progenitors, migrated from the chiasm side, reached the proximal end of LCS, and began myelin formation. Thus the failure in myelin formation at the intraocular part and LCS possibly depended upon unsuccessful migration of oligodendrocytes beyond LCS constructed by specialized astrocytes, although other inhibitory factors for myelin formation, such as adhesion molecules distributed around LCS, may be unsolved.
在小鼠视神经中,穿透眼球后视网膜、视乳头和筛板(lamina cribrosa sclerae,LCS)中的视神经纤维层不能产生髓鞘,而眼眶中的视神经被有髓鞘的神经纤维占据。本研究调查LCS的结构发展,轴突从无髓到有髓的类型,以阐明轴突的初始部分是无髓的。在成人视神经的LCS,发育良好的星形胶质细胞密集地形成了一个细胞质网状框架,无髓纤维通过。星形胶质细胞中含有大量密集的中间胶质纤维和细胞器。星形胶质细胞形成的这个框架似乎在出生后7至14天之间完成,然后少突胶质细胞祖细胞从交叉侧迁移,到达LCS的近端,并开始髓鞘形成。因此,髓磷脂形成的失败在眼内部分和LCS可能依赖于不成功的迁移的少突胶质细胞的LCS由专门的星形胶质细胞构建,虽然其他抑制因素的髓磷脂形成,如粘附分子分布在LCS周围,可能是未解决的。

项目成果

期刊论文数量(40)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
高山 千利: "Normal formation of the postsynaptic elements of GABAergic synapses in the reeler cerebellum"Develop Brain Res. 145. 197-211 (2003)
Chitoshi Takayama:“卷轴小脑中 GABA 突触后元件的正常形成”Develop Brain Res. 145. 197-211 (2003)
  • DOI:
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    0
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  • 通讯作者:
Inoue, Y.et al.: "Development astrocytes in the lamina cribrosa sclerae of the mouse optic nerve, with special reference to myelin formation."Okajima Folia Anatomica Japonica. 79. 143-158 (2002)
Inoue, Y.等人:“小鼠视神经巩膜层中星形胶质细胞的发育,特别是髓磷脂的形成。”Okajima Folia Anatomica Japonica。
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    0
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  • 通讯作者:
井上 芳郎: "Vav3 is regulated during the cell cycle and effects cell division"Proc. Natl. Acad. Sci. USA. 99・7. 4313-4318 (2002)
Yoshiro Inoue:“Vav3 在细胞周期中受到调节并影响细胞分裂”,Proc. 99·4318 (2002)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
井上 芳郎: "Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebeller Purkinje cells lacking glutamate receptor delta 2"J Neurosci.. 22. 8457-8503 (2002)
Yoshiro Inoue:“由于缺乏谷氨酸受体 delta 2 的小脑浦肯野细胞中相邻多刺分支的异常接线而导致攀爬纤维区域的远端延伸和多重神经支配”J Neurosci.. 22. 8457-8503 (2002)
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
井上 芳郎: "Development astrocytes in the lamina cribrosa sclerae of the mouse optic nerve, with special reference to myelin formation"Okajima Folia Anatomica Japonica. 79. 143-158 (2002)
Yoshiro Inoue:“小鼠视神经巩膜层中星形胶质细胞的发育,特别是髓磷脂的形成”Okajima Folia Anatomica Japonica 79. 143-158 (2002)。
  • DOI:
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  • 影响因子:
    0
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INOUE Yoshiro其他文献

INOUE Yoshiro的其他文献

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{{ truncateString('INOUE Yoshiro', 18)}}的其他基金

Analysis of mixing mechanism in 3D fluid system based on the dynamics of streak line lobes
基于条纹线瓣动力学的3D流体系统混合机理分析
  • 批准号:
    22656176
  • 财政年份:
    2010
  • 资助金额:
    $ 3.65万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
ANALYSIS Of FUNCTIONAL MECHAMISM OF GLUTAMATE RECEPTORS IN NEURO-LOGICAL MUTANT MICE BY PHOTOMETRIC SYSTEM.
通过光度系统分析神经突变小鼠谷氨酸受体的功能机制。
  • 批准号:
    07458198
  • 财政年份:
    1995
  • 资助金额:
    $ 3.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
The correlated analysis between the morphological and electrophysiological characteristics of the projection neurons in the reeler cerebral cortex.
Reeler大脑皮层投射神经元形态与电生理特征的相关分析
  • 批准号:
    04670031
  • 财政年份:
    1992
  • 资助金额:
    $ 3.65万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
Alteration of neuronal network in the central nervous system of a dystonic mutant mouse, "Wriggle mouse Sagami"
肌张力障碍突变小鼠“Wriggle mouse Sagami”中枢神经系统神经元网络的改变
  • 批准号:
    02670023
  • 财政年份:
    1990
  • 资助金额:
    $ 3.65万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
The morphological analysis of oligodendrocytic behavior during development of the nerve tracts.
神经束发育过程中少突胶质细胞行为的形态学分析。
  • 批准号:
    62570022
  • 财政年份:
    1987
  • 资助金额:
    $ 3.65万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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