Epidemiological Study on Risk Factors for arteriosclerosis in cerebral small artery expressed as deep white matter signal hyperintensities on MRIs

MRI深部白质信号高信号表现的脑小动脉动脉硬化危险因素的流行病学研究

• 批准号: 14370143
• 负责人: WATANABE Yoshiyuki
• 金额: $ 8.9万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370143/
• 关键词: Arteriosclerosis; White matter signal hyperintensities; Epidemiology; Case-control Study; Hypertension; ラクナ梗塞; 白室病変; 脳梗塞

We have conducted a case-control study on the relation of deep white matter signal hyperintensities on MRIs with body mass index, blood pressure, biomarkers of blood sample, past medical histories, family histories, life style factors, activity of daily living and quality of life. Thirty-nine cases (20 males and 19 females) with the Fazekas classification grade 2 or over diagnosed by MRI were compared with 331 controls with the grade 0 or 1 from the participants of examinees at a human dry doc in 2003 and 2004.Unconditional logistic regression analysis on sex, age and other factors revealed that females, ageing, hypertension, hypertensive or sclerotic change of optic funds, low serum vitamin B12 level, low serum γ tocopherol level, eating pickles 3-4 times per week or more, eating foods boiled down with soy sauce (tsukudani) 3-4 times per week or more, inability of writing down pension application form were increased risk for deep white matter lesions of the brain. Most factors above were consistent with the risk factors for stroke. In adjusted analysis included above risk factors at a time, hypertension and hypertensive and/or sclerotic change of optic funds were still increased the risk of deep white matter lesions of the brain as odds ratio (95% confidence intervals) of hypertension and Keith-Wagener classification I or over were 4.00 (1.53-10.45) and 3.40 (1.25-9.24), respectively.

我们对MRI深部白质信号高信号与体重指数、血压、血液样本生物标志物、既往病史、家族史、生活方式因素、日常生活活动和生活质量的关系进行了病例对照研究。将 39 例经 MRI 诊断为 Fazekas 分类 2 级或以上的病例（男 20 例，女 19 例）与 2003 年和 2004 年人类干医生受试者的 331 例 0 级或 1 级对照者进行比较。 B12 水平、血清γ生育酚水平低、每周吃泡菜3-4次或更多、每周吃酱油煮的食物3-4次或更多、无法写下养老金申请表均会增加大脑深部白质病变的风险。上述大多数因素与中风的危险因素一致。在同时纳入上述危险因素的调整分析中，高血压和高血压和/或视神经基金硬化性改变仍增加脑深部白质病变的风险，高血压和Keith-Wagener分类I或以上的比值比（95%置信区间）分别为4.00（1.53-10.45）和3.40（1.25-9.24）。