Seroepidemiological Study on Upper Gastrointestical Diseases

上消化道疾病血清流行病学研究

• 批准号: 06454243
• 负责人: WATANABE Yoshiyuki
• 金额: $ 4.1万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454243/
• 关键词: gastric cancer; atrophic gastritis; Helicobacter pylori; epidemiolgy; ペプシノゲンI; II比; ヘリコバクター・ピロリ抗体

We conducted a seroepidemiological nested case-control study to determine the association of gastric cancer with Helicobacter pylori infection and atrophic gastritis. A cohort of 2,858 participants in an annual multiphasic health check-up were followed for 8 years. Data for 45 gastric cancer cases and 225 sex, age and address matched control subjects were analyzed. Helicobacter pylori infecction was determined by IgG antibodies, and atrophic gastritis was diagnosed by both serum pepsinogen I level (<=70 ng/ml) and the pepsinogen I/II ratio (<=3.0). Univariate analysis showed that Helicobacter pylori and atrophic gastritis were significantly associated with gastric cancer. In a multivariate analysis, atrophic gastritis was associated with significantly increased risk of cancer (odds ratio, 3.38 ; 95% confidence interval, 1.54-7.42) ; however, Helicobacter pylori was not associated with cancer (odds ratio, 1.84 ; 95% confidence interval, 0.59-5.72). We also conducted a seroepidemiologica … More l cohort study using the Cox Regression model to determine the association of gastric cancer with Helicobacter pylori infection and atrophic gastritis. From a cohort of 2,858 participants in an annual multiphasic health check-up were followed for about 7.5 years. Among the participants, 295 were died, 46 moved to other areas and 45 were diagnosed as gastric cancer by the end of study period. Helicobacter pylori infection and atrophic gastritis were diagnosed by the same methods as nested case-control study. Univariate analysis showed that Helicobacter pylori and atrophic gastritis were significantly associated with gastric cancer. In a multivariate analysis, atrophic gastritis was associated with significantly increased risk of cancer (hazard ratio, 4.01 ; 95% confidence interval, 1.94-8.29) ; however, Helicobacter pylori was not associated with cancer (hazard ratio, 1.56 ; 95% confidence interval, 0.52-4.67). These results suggest that Helicobacter pylori infection alone is not directly associated with gastric carcinogenesis, but has an indirect relation to gastric cancer through the development of atrophic gastritis. Less

我们进行了一项血清流行病学嵌套病例对照研究，以确定胃癌与幽门螺杆菌感染和萎缩性胃炎的关系。一组2858名参与者参加了为期8年的年度多阶段健康体检。对45例胃癌患者和225例性别、年龄、地址匹配的对照组的资料进行分析。血清胃蛋白酶原I水平(<70 ng/ml)和胃蛋白酶原I/II比值(<<3.0)诊断为萎缩性胃炎。单因素分析显示幽门螺杆菌和萎缩性胃炎与胃癌显著相关。在多变量分析中，萎缩性胃炎与癌症风险显著增加相关(优势比3.38；95%可信区间1.54-7.42)；然而，幽门螺杆菌与癌症无关(优势比1.84；95%可信区间0.59-5.72)。我们还进行了血清流行病学…更多的L队列研究采用COX回归模型来确定胃癌与幽门螺杆菌感染和萎缩性胃炎的关系。从参加年度多阶段健康体检的2858名参与者中，对其进行了约7.5年的跟踪调查。在参与者中，295人死亡，46人转移到其他地区，45人在研究结束时被诊断为胃癌。幽门螺杆菌感染和萎缩性胃炎的诊断方法与巢式病例对照研究相同。单因素分析显示幽门螺杆菌和萎缩性胃炎与胃癌显著相关。在多变量分析中，萎缩性胃炎与癌症风险显著增加相关(风险比4.01；95%可信区间1.94-8.29)；然而，幽门螺杆菌与癌症无关(风险比1.56；95%可信区间0.52-4.67)。这些结果表明，幽门螺杆菌单独感染与胃癌的发生没有直接关系，但通过萎缩性胃炎的发展与胃癌有间接关系。较少