Clinical Application of DNA Methylation Analysis Using Gastric Washes as an ESD Treatment Marker for Early Gastric Cancer

使用胃洗液进行 DNA 甲基化分析作为早期胃癌 ESD 治疗标志物的临床应用

• 批准号: 22501038
• 负责人: WATANABE Yoshiyuki
• 金额: $ 2.58万
• 依托单位: St. Marianna University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22501038/
• 关键词: 胃がん; メチル化; 胃洗浄廃液; 胃癌; DNAメチル化; EMR; ESD; Sox17; MINT25

We have developed a new methodology for gastric cancer detection by DNA methylation in gastric washes. It is easy and useful for early detection of recurrence after endoscopic treatment in GCa patients. We now have on going prospective studies.

我们已经开发了一种通过胃洗涤剂中DNA甲基化的胃癌检测的新方法。对于GCA患者内窥镜治疗后，它容易且有用。我们现在有前瞻性研究。

项目成果

DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis.

• DOI: 10.1371/journal.pone.0027889
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Konishi K;Watanabe Y;Shen L;Guo Y;Castoro RJ;Kondo K;Chung W;Ahmed S;Jelinek J;Boumber YA;Estecio MR;Maegawa S;Kondo Y;Itoh F;Imawari M;Hamilton SR;Issa JP
• 通讯作者: Issa JP

Gastric Wash-Based Sox17 Methylation is Useful as a Molecular Diagnostic Application in Early Stage of Gastric Cancer

基于胃洗液的 Sox17 甲基化可作为胃癌早期的分子诊断应用

• 发表时间: 2012
• 作者: Sato;A.;Kudo;C.;Yamakoshi;H.;Uehara;Y.;Ohor,i H.;Ishioka;C.;Iwabuchi;Y. Shibata H.;田中宏幸;Yoshiyuki Watanabe
• 通讯作者: Yoshiyuki Watanabe

The Sox17 Gene Hypermethylation is Useful as a Molecular Diagnostic Application in Early Stage of Gastric Cancer.

Sox17 基因高甲基化可作为胃癌早期的分子诊断应用。

• 发表时间: 2012
• 作者: Hama R;Watanabe Y et al.
• 通讯作者: Watanabe Y et al.

Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer.

• DOI: 10.1371/journal.pone.0023320
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Watanabe Y;Castoro RJ;Kim HS;North B;Oikawa R;Hiraishi T;Ahmed SS;Chung W;Cho MY;Toyota M;Itoh F;Estecio MR;Shen L;Jelinek J;Issa JP
• 通讯作者: Issa JP

Usefulness of DNA methylation analysis using gastric washes as a treatment marker for early gastric cancer

使用胃洗液进行 DNA 甲基化分析作为早期胃癌治疗标志物的有用性

• 发表时间: 2011
• 作者: 高田龍平;山梨義英;鈴木洋史;Watanabe Y et al
• 通讯作者: Watanabe Y et al