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The development of 3-D computer simulation system for hyperthermic treatment of malignant brain tumor

恶性脑肿瘤热疗3D计算机模拟系统的研制

基本信息

批准号：
14370427
负责人：
TAKAHASHI Hideaki
金额：
$ 8.38万
依托单位：
NIIGATA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370427/
关键词：
malignant brain tumor hyperthermia computer simulation RF three-dimensional interstisial 組織内加温

项目摘要

Using thermal simulation software that we independently based on the 2-dimensional finite element method, we have previously described a treatment protocol for interstitial hyperthermia and understanding of thermal distributions in two dimensions. The present investigation examined 3-dimensional simulation of thermal distributions.Since 2002, we have conducted basic research on electromagnetic field analysis using RF waves. This involved using the previous 2-dimensional finite element method to solve Maxwell equations and differentiate in space and time regions, and the algorithm for this method was applied to three dimensions. Although analysis using a model of the human brain was not possible in the 2002 investigation, a 3-dimensional simulation using a phantom model was performed. Specifically, a 3-dimensional simulation of re-entrant heating, a centrifugal heating method similar to interstitial hyperthermia, was achieved.Next, using Vitrea 2 imaging software (Vital Images), a 3-dim … More ensional model was constructed through computer reconstruction of 2-dimensional cranial CT or MRI images from patients with brain tumors. Application of this method provided surgically useful images.In 2003, using JMAG electromagnetic field analysis software, a thermal simulation was performed for a phantom model heating with a re-entrant-type applicator. When the phantom was heated and temperature measured using an optical fiber, thermal distribution was found to very closely approximate predicted temperatures.Based on the 3-dimensional model tumor was attempted using JMAG software. Due to the complexity of the tumor shape, however, analysis of the distribution was not achieved.Although phantom studies showed accuracy of the predicted 3-dimensional distributions to be suitable for clinical application, the complexity of the method poses an obstacle to use in clinical apply. Efficacy of hyperthermia treatment depends on accurate heating, and predicting 3-dimensional thermal distribution will therefore become an essential aspect of the treatment protocol. The present investigation completed the first step toward system that applies simulation of 2-dimensional thermal distributions to three dimensions. We will continue to expand on this work, and we anticipate that the reliable hyperthermia that will result from safe treatment protocols will contribute to improvements in the efficacy of treatment for malignant brain tumors. Less

使用热模拟软件，我们独立的基础上的二维有限元法，我们以前已经描述了一个治疗方案，间质热疗和理解的热分布在两个维度。从2002年开始，我们进行了基于RF波的电磁场分析的基础研究。这涉及到使用以前的二维有限元方法来求解麦克斯韦方程组并在空间和时间区域中进行微分，并且将该方法的算法应用于三维。虽然在2002年的研究中无法使用人脑模型进行分析，但使用体模模型进行了三维模拟。具体地，实现了再入加热（类似于组织间热疗的离心加热方法）的三维模拟。 ...更多信息通过计算机重建脑肿瘤患者的二维头颅CT或MRI图像，建立肿瘤的三维模型。2003年，使用JMAG电磁场分析软件，对使用再入式施源器加热的体模模型进行了热模拟。当加热体模并使用光纤测量温度时，发现热分布非常接近预测的温度。然而，由于肿瘤形状的复杂性，没有实现分布的分析，尽管体模研究表明预测的三维分布的准确性适合于临床应用，但该方法的复杂性对临床应用构成了障碍。热疗的有效性取决于准确的加热，因此预测三维热分布将成为治疗方案的一个重要方面。本研究完成了将二维热分布模拟应用于三维系统的第一步。我们将继续扩大这项工作，我们预计安全治疗方案产生的可靠的热疗将有助于改善恶性脑肿瘤的治疗效果。少