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Development of linear motor driven pulsatile ventricular assist device

直线电机驱动脉动心室辅助装置的研制

基本信息

批准号：
14380416
负责人：
FUKUI Yasuhiro
金额：
$ 9.22万
依托单位：
Tokyo Denki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14380416/
关键词：
Artificial Heart Ventricular Assist Device Linear Motor Linear Oscillatory Actuator Non-Symmetrical Thrust Characteristics Magnetic Field Analysis Movement Converter Chronic Animal Experiment 真空注型磨耗血栓摩耗

项目摘要

Heart transplantation is a reliable way to treat patients with severe cardiac failure. The limited number of donor hearts available requires the establishment of alternative treatments for these patients. A left ventricular assist device(VAD) has been used for such patients and has shown reliable results as a bridge to heart transplantation. Electromechanical and electrohydraulic mechanisms have been reported as the driving mechanisms for pulsatile VADs. These require a movement converter, such as a roller screw. This causes problems in that the use of the movement converter prevents the VAD from becoming smaller and reduces the reliability of the VAD.In this study, a new implantable direct electromagnetic VAD (Linear-VAD) was developed, that uses a linear oscillatory actuator(LOA) without any movement converter. A magnetic field analysis was applied to examine proposal structures and to design LOA. The three proposal structures of LOA are as follows :(1)New structure of the Inner-Stator/Outer-Mover.(2)New structure which has the non-symmetrical thrust characteristics.(3)The structure to improve the starting thrust.The dimensions of prototype LOA are 60 mm in diameter, 24 mm in thickness, with a mass of 465 g and a volume of 68 mL, Moreover, the prototype Linear-VAD was developed that uses the LOA. The dimensions of the first prototype Linear-VAD are 96 mm in diameter, 50 mm in thickness, with a mass of 0.62 kg and a volume of 280 mL. An in vitro test demonstrated over 10 L/min maximum output and 18 % maximum efficiency. The Linear-VAD was evaluated for pump performance, long-term durability in a chronic animal experiment. The goat implanted with the Linear-VAD survived for 42 days. The Linear-VAD had no troubles relating to the electronic control unit or the electronic drive line. The experiment confirmed the durability of the Linear-VAD for 42 days.

心脏移植是治疗严重心力衰竭的可靠方法。有限数量的供体心脏需要为这些患者建立替代治疗方法。左心室辅助装置（VAD）已被用于此类患者，并已显示出可靠的结果，作为心脏移植的桥梁。机电和电液机制已被报道为搏动性VAD的驱动机制。这些需要运动转换器，例如滚柱丝杠。在这项研究中，开发了一种新的植入式直接电磁VAD（线性VAD），它使用线性振荡致动器（LOA）没有任何运动转换器。应用磁场分析来检查提议的结构和设计LOA。LOA的三种建议结构如下：（1）内定子/外动子的新结构。（2）具有非对称推力特性的新型结构。（3）提高起动推力的结构设计：样机的尺寸为直径60 mm，厚度24 mm，质量465 g，体积68 mL。第一个原型Linear-VAD的尺寸为直径96 mm，厚度50 mm，质量0.62 kg，体积280 mL。体外试验表明，最大输出超过10 L/min，最大效率为18%。在慢性动物实验中评价了Linear-VAD的泵性能和长期耐用性。植入Linear-VAD的山羊存活了42天。Linear-VAD没有与电子控制单元或电子驱动线路相关的故障。实验证实了Linear-VAD的耐用性为42天。