Development of an Integrated Cardiopulmonary Support System

综合心肺支持系统的开发

• 批准号: 07044164
• 负责人: FUKUI Yasuhiro
• 金额: $ 8.9万
• 依托单位: Tokyo Denki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07044164/
• 关键词: cardiopulmonary support system; centrifugal blood pump; oxygenator; silicone hollow fiber; pivot bearing; ECMO; 定常流補助循環; 膜型人工肺

In this research project, the following studies were conducted :(1) Development of a novel fine silicone hollow fiber for membrane oxygenator suitable for long term application and development of membrane oxygenator using the newly developed silicone hollow fiber(2) Development of a compact centrifugal blood pump system for long term application(3) Design of an integrated cardio-pulmonary support system with the developed system componentsOne of the limitaion of conventional silicone hollow fiber oxygenator is poor gas permeability. However, the silicone hollow fiber is free from plsam leakage, which is the major life limiting factor of the microporous membrane oxygenator. It has been difficult to fabricate a fine, thin hollow fiber for reduction of resistance to gas permeability because of the poor mechanical strength of conventional silicone materials. We have developed a novel silicone material with sufficient mechanical strength and fine silicone hollow fiber with an inner diameter … More of 30 mum and wall thickness of 50 mum which is approximately half of those of a conventional silicone hollow fiber. One of the difficulties in fabricating the oxygenator using the developed silicone hollow fiber is the collapse of the hollow fiber due to external force applied. By controlling the tension applied to the hollow fiber during winding process, we could minimize the collapse of hollow fiber during fabrication process. The oxygen and carbon dioxide transfer rates of the developed membrane oxygenator that have surface area of 2.0 m^2 were 195ml/min and 165ml/min respectively. The novel silicone membrane oxygenator developed in this study can be used for extended duration in such application as extracorporeal membrane oxygenation.In the centrifugal blood pump study the pump head where the impeller was supported by two ceramic pivot bearings was developed that was free from sea-shaft related problems of conventional centrifugal blood pumps. The impeller was driven by magnetically coupled diving system. For application to cardio pulmonary support system a new driver consisting of a compact dc brushless motor was developed. The distance between two coupling magnet could be adjusted to stabilize the motion of impeller utilizing a cam mechanism. The width, length and height of the driver were 134mm, 177mm, and 66.7 mm respectively. The system can generate 31/min against 529 mmHg.We combined the developed pump system and silicone hollow fiber membrane oxygenator and verified the basic performance of the system. At flow rate of 3L/min, the pressure drop across the oxygenator was approximately 35 mmHg. Thus the combined system have enough capability to generate 31/min even if the pressure head required is larger than 300 mmHg due to cardiovascular resistance and cannula resistance. Less

本课题主要进行了以下几方面的研究：（1）开发一种适合长期应用的新型精细硅中空纤维膜式氧合器，并利用新开发的硅中空纤维膜式氧合器进行开发;（2）开发一种适合长期应用的紧凑型离心式血泵系统;（3）设计一种集成心肺支持系统。然而，硅胶中空纤维没有plsam泄漏，这是微孔膜式氧合器的主要寿命限制因素。由于常规有机硅材料的机械强度差，因此难以制造用于降低透气性阻力的细而薄的中空纤维。我们开发了一种新型的有机硅材料，具有足够的机械强度和内径为100 mm的精细有机硅中空纤维。 ...更多信息 30 μ m和50 μ m的壁厚，这大约是常规硅酮中空纤维的壁厚的一半。使用所开发的硅酮中空纤维制造氧合器的困难之一是中空纤维由于施加的外力而塌陷。通过控制缠绕过程中施加在中空纤维上的张力，可以最大限度地减少中空纤维在制造过程中的塌陷。所研制的表面积为2.0m^2的膜式氧合器的氧和二氧化碳传递速率分别为195 ml/min和165 ml/min。本研究中开发的新型硅胶膜式氧合器可用于体外膜式氧合等应用中，在离心血泵研究中，开发了由两个陶瓷枢轴轴承支撑叶轮的泵头，该泵头不存在传统离心血泵的海轴相关问题。叶轮由磁耦合驱动系统驱动。为应用于心肺支持系统，研制了一种由小型直流无刷电机组成的新型驱动器。利用凸轮机构可调节两耦合磁体之间的距离以稳定叶轮的运动。改锥的宽、长、高分别为134 mm、177 mm、66.7mm。该系统在529 mmHg压力下可产生31次/min的流量，并将研制的泵系统与硅胶中空纤维膜式氧合器相结合，验证了系统的基本性能。流速为3 L/min时，氧合器的压降约为35 mmHg。因此，即使由于心血管阻力和插管阻力而需要的压头大于300 mmHg，组合系统也有足够的能力产生31/min。少

项目成果

熊谷 剛、舟久保 昭夫 他: "人工肺内血液流動シミュレーションに関する研究" 第13回ライフサポート学会大会講演予稿集. 148- (1997)

Tsuyoshi Kumagai、Akio Funakubo 等人：“人工肺血流模拟研究”第 13 届生命支持学会会议记录 148- (1997)。

船久保昭夫、福井康裕: "小口径シリコン中空糸を用いた人工肺の開発" 医用電子と生体工学. 33 (suppl). 519-519 (1995)

Akio Funakubo、Yasuhiro Fukui：“使用小直径硅中空纤维开发人工肺”《医疗电子和生物工程》33（增刊）。

船久保昭夫、福井康裕、佐藤耕司郎: "小口径シリコン中空糸を用いた外部潅流型人工肺の開発" 人工臓器. 24 (suppl). S-94-S-74 (1995)

Akio Funakubo、Yasuhiro Fukui、Kojiro Sato：“使用小直径硅胶中空纤维开发外部灌注氧合器”人工器官 24（增刊）。

Nobumasa Katagiri, Akio Funakubo, Shigenobu Suzuki, Yukio Sekiguvhi, Yasuhiro Fukui, Koshiro Sato: "Development of an Intracapillary flow type oxygenator using Silicone hollow fiber." 13th congress of life support technology. Vol.13. 149 (1997)

Nobumasa Katagiri、Akio Funakubo、Shigenobu Suzuki、Yukio Sekiguvhi、Yasuhiro Fukui、Koshiro Sato：“使用硅胶中空纤维开发毛细管内流动型氧合器。”

Shahriar Ahmed, Ichiro Sakuma, Yasuhiro Fukui, Takeyoshi Dohi: "Experimental Assessment of hemolysis on centrifugal blood pump." 13th congress of life support technology. Vol.13. 37 (1997)

Shahriar Ahmed、Ichiro Sakuma、Yasuhiro Fukui、Takeyoshi Dohi：“离心血泵溶血的实验评估”。