The effects of prenatal exposures to environmental chemicals and genetic susceptibility on growth, neurodevelopment and allergy of next generation

札幌市一家产科医院招募了514名孕妇。我们调查了产前暴露于多氯联苯/多氯二苯并二恶英/多氯二苯并呋喃、全氟辛烷磺酸和全氟辛烷磺酸与儿童生长发育、神经发育和下一代至学龄期过敏的相关性。在18个月、42个月和84个月龄时进行跟踪调查，以获得包括婴儿症状和生活方式因素在内的相关信息。6个月和18个月时采用贝利婴幼儿发展量表第二版，42~43个月和84个月时使用考夫曼儿童成套评估工具和儿童行为检查表收集儿童行为信息。在84个月大时，使用韦氏儿童智力量表评估环境化学物质对认知能力的影响。分别用高分辨气相色谱/高分辨质谱仪和液相色谱-串联质谱仪分析母血中的多氯联苯/多氯联苯并二恶英和全氟辛烷磺酸/全氟辛酸。

514 pregnant women were recruited in one obstetric hospital in Sapporo. We investigated the correlation of prenatal exposures to PCBs/PCDDs/PCDFs, PFOS and PFOA with child growth, neurodevelopment, and allergy in next generation until school age. A follow-up questionnaire was used at 18, 42, and 84 months of age to obtain relevant information including infant symptoms and lifestyle factors. The Bayley Scale of Infant Development second edition at age of 6 and 18 months, and the Kaufman Assessment Battery for Children and the Child Behavior Checklist at age 42 to 43, 84 months were employed to collect information on child behavior. At age of 84 months the Wechsler Intelligence Scale for Children was used to assess the effects of environmental chemicals on cognitive ability. The levels of PCBs/PCDDs/PCDFs and PFOS/PFOA in maternal blood were analyzed by a high-resolution gas chromatography/high-resolution mass spectrometer and liquid chromatography-tandem mass spectrometry respectively.