The effects of prenatal exposures to environmental chemicals and genetic susceptibility on growth, neurodevelopment and allergy of next generation

在札幌的一家产科医院招募了514名孕妇。我们调查了产前暴露于多氯联苯/多氯联苯/多氯联苯、全氟辛烷磺酸和全氟辛酸与儿童生长、神经发育和下一代过敏的相关性，直到学龄期。在18个月、42个月和84个月时进行随访问卷调查，以获得包括婴儿症状和生活方式因素在内的相关信息。采用6月龄和18月龄的Bayley婴儿发育量表（第二版）、42 ~ 43,84月龄的Kaufman儿童评估量表和儿童行为检查表收集儿童行为信息。在84个月大时，使用韦氏儿童智力量表来评估环境化学物质对认知能力的影响。采用高分辨率气相色谱/高分辨率质谱联用仪和液相色谱-串联质谱联用仪分别检测母体血液中PCBs/PCDDs/PCDFs和PFOS/PFOA的含量。

514 pregnant women were recruited in one obstetric hospital in Sapporo. We investigated the correlation of prenatal exposures to PCBs/PCDDs/PCDFs, PFOS and PFOA with child growth, neurodevelopment, and allergy in next generation until school age. A follow-up questionnaire was used at 18, 42, and 84 months of age to obtain relevant information including infant symptoms and lifestyle factors. The Bayley Scale of Infant Development second edition at age of 6 and 18 months, and the Kaufman Assessment Battery for Children and the Child Behavior Checklist at age 42 to 43, 84 months were employed to collect information on child behavior. At age of 84 months the Wechsler Intelligence Scale for Children was used to assess the effects of environmental chemicals on cognitive ability. The levels of PCBs/PCDDs/PCDFs and PFOS/PFOA in maternal blood were analyzed by a high-resolution gas chromatography/high-resolution mass spectrometer and liquid chromatography-tandem mass spectrometry respectively.