Therapeutic strategy of drug delivery systems utilizing unique tumor environment
Therapeutic strategy of drug delivery systems utilizing unique tumor environment
批准号:
23240072
负责人:
HASHIDA Mitsuru
金额:
$32.03万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
Cancer cells establish tumor environment that allows them to resist stressful conditions such as low oxygen and low nutrients and escape host immune responses. The present investigation aimed at developing innovative anti-cancer therapeutic systems with paying attention to the unique characteristics of tumorous tissues from those of normal tissues. To achieve this goal, we focused on nucleic acid drugs with high specificity that can break the resistance systems in cancer, and developed effective delivery systems for the drugs to the target by combination of physical and chemical means.
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Inhibition of tumor growth by NF-kappaB decoy transfection into TAM using mannose-modified bubble lipoplexes in mice
使用甘露糖修饰的气泡脂质体复合物将 NF-kappaB 诱饵转染至 TAM 中抑制肿瘤生长
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[河野裕允, 川上茂, 鈴木亮, 丸山一雄, 橋田充]
通讯作者:
橋田充
Evalustion of endosomal escape of lysine-histidine dendrons by live cell imaging
通过活细胞成像评估赖氨酸-组氨酸树突的内体逃逸
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yuriko Higuchi, Kai-ling Chang, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida]
通讯作者:
Mitsuru Hashida
Inhibition of tumor growth by NF-κ B decoy transfection into TAM using mannose-modified bubble lipoplexes in mice
使用甘露糖修饰的气泡脂质复合物将 NF-κB 诱饵转染至 TAM 来抑制小鼠肿瘤生长
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[河野裕允, 川上 茂, 鈴木 亮, 丸山一雄, 橋田 充]
通讯作者:
橋田 充
マンノース修飾バブルリポソームを用いたNF-kappaB 活性制御による腫瘍関連マクロファージのphenotype 変化
使用甘露糖修饰的气泡脂质体控制 NF-κB 活性来改变肿瘤相关巨噬细胞的表型
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[河野裕允, 川上 茂, 樋口ゆり子, 鈴木 亮, 丸山一雄, 山下富義, 橋田 充]
通讯作者:
橋田 充
DOI:
10.1002/anie.201204596
发表时间:
2012-01-01
期刊:
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
影响因子:
16.6
作者:
[Kasai, Hitoshi, Murakami, Tatsuya, Hashida, Mitsuru]
通讯作者:
Hashida, Mitsuru
共 15 条
Development of novel gene-switch system inducing inflammatory tissue-selective gene expression and realizing DDS for stem cell
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批准号:25670259
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2013
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负责人:HASHIDA Mitsuru
-
依托单位:
Long-term gene expression in primary cells by transposon and its application for cell therapy
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批准号:23659284
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:HASHIDA Mitsuru
-
依托单位:
Development of bioimaging method and targeted drug delivery system for inhibiting tumor proliferation and metastasis
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批准号:17016035
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$63.87万
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财政年份:2005
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负责人:HASHIDA Mitsuru
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依托单位:
Strategy for optimization of in vivo gene delivery based on systemic control of delivery and transfection
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批准号:15209006
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.12万
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财政年份:2003
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负责人:HASHIDA Mitsuru
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依托单位:
Optimized the gene and drug delivery using liposomes based on the controlled liposomal surface property
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批准号:13470477
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.43万
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财政年份:2001
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负责人:HASHIDA Mitsuru
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依托单位:
分子軌道法とニューラルネットワークを基盤とした薬物吸収予測システムの開発
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批准号:11557192
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$7.74万
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财政年份:1999
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负责人:HASHIDA Mitsuru
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依托单位:
動態-発現相関の解析に基づくin vivo遺伝子導入キャリアーシステムの分子設計
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批准号:10470492
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项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$8.38万
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财政年份:1998
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负责人:HASHIDA Mitsuru
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依托单位:
Systematic development of targeting systams for prevention of tissue damages in organ transplantation
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批准号:08557145
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.16万
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财政年份:1996
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负责人:HASHIDA Mitsuru
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依托单位:
Establishment of the theory based on a skin diffusion model for the optimal design of a new approach to enhanced trandermal drug delivery
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批准号:07457529
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.86万
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财政年份:1995
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负责人:HASHIDA Mitsuru
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依托单位:
Establishment of Evaluation Method for Function of Drug Targeting Systems and Systematization of their Physicochemical Character-Function Relationship
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批准号:05452338
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.54万
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财政年份:1993
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负责人:HASHIDA Mitsuru
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依托单位:
Pharmacokinetic modeling and penetration enhancement of the percutaneous drug absorption based on diffusion theory
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批准号:02670977
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.54万
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财政年份:1990
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负责人:HASHIDA Mitsuru
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依托单位:
Establishment of a new theory for assessment of drug disposition
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批准号:63571093
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1988
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负责人:HASHIDA Mitsuru
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依托单位:
海外基金