Development of bioimaging method and targeted drug delivery system for inhibiting tumor proliferation and metastasis
Development of bioimaging method and targeted drug delivery system for inhibiting tumor proliferation and metastasis
批准号:
17016035
负责人:
HASHIDA Mitsuru
金额:
$63.87万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
Anti tumor therapy, which generally applicapable for several tumors, has never established, because of the diversity of distribution and condition of tumor cells or the hurdle of targeted delivery of antitumor drugs. In this study, we established the visualization and quantitative method using bioimaging, which became the foundation for non-invasive analysis of the process or tumor proliferation and metastasis. Furthermore, based on the concept of DDS, we developed the carrier for antitumor drugs or gene medicine and apply them for antitumor therapy.
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DOI:
10.1016/j.jconrel.2009.04.005
发表时间:
2009-07-20
期刊:
JOURNAL OF CONTROLLED RELEASE
影响因子:
10.8
作者:
[Hyoudou, Kenji, Nishikawa, Makiya, Hashida, Mitsuru]
通讯作者:
Hashida, Mitsuru
カタラーゼデリバリーによる癌の接着抑制
通过过氧化氢酶递送抑制癌症粘附
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[古林裕貴, 西川元也, 橋田充]
通讯作者:
橋田充
DOI:
10.1038/sj.ki.5002556
发表时间:
2007-12-01
期刊:
KIDNEY INTERNATIONAL
影响因子:
19.6
作者:
[Ma, S-F, Nishikawa, M., Hashida, M.]
通讯作者:
Hashida, M.
DOI:
10.1007/s11095-007-9398-x
发表时间:
2008-02
期刊:
Pharmaceutical Research
影响因子:
3.7
作者:
[Narin Chansri;S. Kawakami;M. Yokoyama;Tatsuhiro Yamamoto;Pensri Charoensit;M. Hashida]
通讯作者:
Narin Chansri;S. Kawakami;M. Yokoyama;Tatsuhiro Yamamoto;Pensri Charoensit;M. Hashida
DOI:
10.1016/j.canlet.2009.05.037
发表时间:
2010
期刊:
Cancer letters
影响因子:
9.7
作者:
[Shuwen Zhou;S. Kawakami;F. Yamashita;M. Hashida]
通讯作者:
Shuwen Zhou;S. Kawakami;F. Yamashita;M. Hashida
共 40 条
Development of novel gene-switch system inducing inflammatory tissue-selective gene expression and realizing DDS for stem cell
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批准号:25670259
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2013
-
负责人:HASHIDA Mitsuru
-
依托单位:
Long-term gene expression in primary cells by transposon and its application for cell therapy
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批准号:23659284
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:HASHIDA Mitsuru
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依托单位:
Therapeutic strategy of drug delivery systems utilizing unique tumor environment
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批准号:23240072
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.03万
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财政年份:2011
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负责人:HASHIDA Mitsuru
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依托单位:
Strategy for optimization of in vivo gene delivery based on systemic control of delivery and transfection
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批准号:15209006
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.12万
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财政年份:2003
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负责人:HASHIDA Mitsuru
-
依托单位:
Optimized the gene and drug delivery using liposomes based on the controlled liposomal surface property
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批准号:13470477
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.43万
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财政年份:2001
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负责人:HASHIDA Mitsuru
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依托单位:
分子軌道法とニューラルネットワークを基盤とした薬物吸収予測システムの開発
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批准号:11557192
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$7.74万
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财政年份:1999
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负责人:HASHIDA Mitsuru
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依托单位:
動態-発現相関の解析に基づくin vivo遺伝子導入キャリアーシステムの分子設計
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批准号:10470492
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.38万
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财政年份:1998
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负责人:HASHIDA Mitsuru
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依托单位:
Systematic development of targeting systams for prevention of tissue damages in organ transplantation
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批准号:08557145
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.16万
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财政年份:1996
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负责人:HASHIDA Mitsuru
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依托单位:
Establishment of the theory based on a skin diffusion model for the optimal design of a new approach to enhanced trandermal drug delivery
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批准号:07457529
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.86万
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财政年份:1995
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负责人:HASHIDA Mitsuru
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依托单位:
Establishment of Evaluation Method for Function of Drug Targeting Systems and Systematization of their Physicochemical Character-Function Relationship
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批准号:05452338
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.54万
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财政年份:1993
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负责人:HASHIDA Mitsuru
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依托单位:
Pharmacokinetic modeling and penetration enhancement of the percutaneous drug absorption based on diffusion theory
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批准号:02670977
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.54万
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财政年份:1990
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负责人:HASHIDA Mitsuru
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依托单位:
Establishment of a new theory for assessment of drug disposition
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批准号:63571093
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1988
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负责人:HASHIDA Mitsuru
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依托单位:
海外基金