Molecular Epidemiology of HIV in Northern India and Pakistan

印度北部和巴基斯坦艾滋病毒分子流行病学

• 批准号: 11691204
• 负责人: YAMAMOTO Naohiko
• 金额: $ 4.16万
• 依托单位: NAGOYA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11691204/
• 关键词: HIV; Molecular Epidemiology; India; Pakistan

The purpose of this project is to clarily the genetic findings, the transmission and the geographic distribution of HIV strains in Northern India and Pakistan and to provide important basic information which will be able to protect against HIV and to develop the vaccination for AIDS.We previously reported that the HIV subtype B was predominantly found in Northern India and was suggested to transmit from HIV-1 subtype B infected intravenous drug users (IVDUs) in Thailand and/or Myammer, while the subtype C was common found in Southern India where HIV was known to transmit from Africa.Last year we analyzed genetic homology between the subtype B of HIV-1 infected IVDUs in Manipur located at north-east in India, the same border in Myammer and the one in Thailand and Myammer. The results revealed that the subtype B of HIV-1 infected IVDUs in Manipur was genetically different from the one in Thailand and Myammer.This year the genetic findings of HIV-1 which spread in Pakistan were investigated. Of 13 HIV-1 infected patients, seven are subtype B, three are subtype C, two are mixed with subtype A and B, one is subtype E.Many male workers in Pakistan used to visit Persian Gulf States where lots of commercial sex workers come to work from south-east Asia. While one of seven subtype B strains is similar to one of African type B, six subtype B is not in the same cluster as one in Thailand and Myammer, but very close to US type B.The data suggested that The HIV-1 subtype B patients infected in Persian Gulf States were transmitted with commercial sex workers in the countries in east-south Asia where US type B were spread.

这个项目的目的是明确基因发现，本研究旨在了解印度北方和巴基斯坦HIV毒株的传播和地理分布，为预防HIV感染和发展艾滋病疫苗提供重要的基础信息。我们以前报道过，HIV亚型B主要在印度北方发现，并建议从HIV-1传播。在泰国和/或缅甸发现了1例B亚型感染的静脉吸毒者，而C亚型则常见于印度南部，已知HIV是从非洲传播的。去年我们分析了位于印度东北部的曼尼普尔的HIV-1感染的静脉吸毒者的B亚型之间的遗传同源性，Myammer的同一边界以及泰国和Myammer的同一边界。结果显示，曼尼普尔地区感染HIV-1的静脉吸毒者的B亚型在遗传上与泰国和缅甸的不同。在13名感染者中，7人为B亚型，3人为C亚型，2人为A和B亚型混合，1人为E亚型。7个亚型B毒株中有1个与非洲B亚型毒株相似，6个亚型B毒株与泰国和缅甸的1个亚型不在同一群，但与美国B亚型毒株非常接近。数据表明，在波斯湾国家感染的HIV-1亚型B患者与美国B亚型毒株传播的东南亚国家的商业性工作者传播。

项目成果

Muhammad Rafiq et al.: "Survey Regarding AIDS Awareness Among Indigenous Population at Karachi"Hamdard Medicus. Vol.XLIII, No.4. 16-20 (2000)

Muhammad Rafiq 等人：“卡拉奇土著居民艾滋病意识调查”Hamdard Medicus。

Muhmmad Rafiq, et al.: "Survey Regarding AIDS Awareness Among Indigenous Population at Karachi"Hamdard Medicus. XLIII. 16-20 (2000)

Muhmmad Rafiq 等人：“卡拉奇土著居民艾滋病意识调查”Hamdard Medicus。

Naoki Mochizuk, et al: "An Infectious DNA Clone of HIV Type 1 Subtype C."AIDS Research and Human Retroviruses. 15(14). 1321-1324 (1999)

Naoki Mochizuk 等人：“HIV 1 型 C 亚型的传染性 DNA 克隆”。艾滋病研究和人类逆转录病毒。

Muhmmad.Rafiq et al.: "Survey Regarding AIDS Awareness Among Indigenous Population at Karachi"Hamdard Medicus. XL111. 16-20 (2000)

Muhmmad.Rafiq 等人：“卡拉奇土著居民艾滋病意识调查”Hamdard Medicus。