Molecular Epidemiology

分子流行病学

• 批准号: MC_UU_00032/4
• 金额: $ 21.79万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00032%2F4
• 关键词: Molecular; Epidemiology

DNA methylation is an epigenetic modification that has potential to provide insights into disease mechanisms but also to predict the risk of future disease, irrespective of its causal role in disease processes. This programme of work will extend our knowledge of population level variation in DNA methylation and investigate the relevance of this variation in disease. We will seek to identify novel biomarkers of disease onset and disease progression and model ways in which these biomarkers can be use to stratify groups according to risk.

DNA甲基化是一种表观遗传修饰，有可能提供对疾病机制的见解，但也可以预测未来疾病的风险，无论其在疾病过程中的因果作用如何。这项工作计划将扩展我们对DNA甲基化的群体水平变异的认识，并研究这种变异与疾病的相关性。我们将寻求确定疾病发作和疾病进展的新生物标志物，以及这些生物标志物可用于根据风险对组进行分层的模型方法。

项目成果

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood.

• DOI: 10.1038/s41467-023-40607-0
• 发表时间: 2023-08-25
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Issarapu, Prachand;Arumalla, Manisha;Elliott, Hannah R.;Nongmaithem, Suraj S.;Sankareswaran, Alagu;Betts, Modupeh;Sajjadi, Sara;Kessler, Noah J.;Bayyana, Swati;Mansuri, Sohail R.;Derakhshan, Maria;Krishnaveni, G. V.;Shrestha, Smeeta;Kumaran, Kalyanaraman;Di Gravio, Chiara;Sahariah, Sirazul A.;Sanderson, Eleanor;Relton, Caroline L.;Ward, Kate A.;Moore, Sophie E.;Prentice, Andrew M.;Lillycrop, Karen A.;Fall, Caroline H. D.;Silver, Matt J.;Chandak, Giriraj R.
• 通讯作者: Chandak, Giriraj R.

Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study.

• DOI: 10.2337/db22-0504
• 发表时间: 2023-03-01
• 期刊: Diabetes
• 影响因子: 7.7

Role of DNA methylation in the relationship between glioma risk factors and glioma incidence: a two-step Mendelian randomization study.

• DOI: 10.1038/s41598-023-33621-1
• 发表时间: 2023-04-21
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Howell, Amy E. E.;Relton, Caroline;Martin, Richard M. M.;Zheng, Jie;Kurian, Kathreena M. M.
• 通讯作者: Kurian, Kathreena M. M.

Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth.

• DOI: 10.1186/s12916-022-02685-7
• 发表时间: 2023-01-11
• 期刊: BMC MEDICINE
• 影响因子: 9.3
• 作者: Alfano, Rossella;Zugna, Daniela;Barros, Henrique;Bustamante, Mariona;Chatzi, Leda;Ghantous, Akram;Herceg, Zdenko;Keski-Rahkonen, Pekka;de Kok, Theo M.;Nawrot, Tim S.;Relton, Caroline L.;Robinson, Oliver;Roumeliotaki, Theano;Scalbert, Augustin;Vrijheid, Martine;Vineis, Paolo;Richiardi, Lorenzo;Plusquin, Michelle
• 通讯作者: Plusquin, Michelle

A genetically informed Registered Report on adverse childhood experiences and mental health.

• DOI: 10.1038/s41562-022-01482-9
• 发表时间: 2023-03
• 期刊: Nature human behaviour
• 影响因子: 29.9
• 作者: Baldwin JR;Sallis HM;Schoeler T;Taylor MJ;Kwong ASF;Tielbeek JJ;Barkhuizen W;Warrier V;Howe LD;Danese A;McCrory E;Rijsdijk F;Larsson H;Lundström S;Karlsson R;Lichtenstein P;Munafò M;Pingault JB
• 通讯作者: Pingault JB