Complicated falciparum malaria

我们访问了泰国和海南岛的三亚，中国在南亚调查了严重恶性疟疾(SM)的情况，并采集了正常成人(NA)和恶性疟疾患者(PF)的血样(1999年12月)。我们参加了“第二届国际热带病会议”，收集了岛内和南方的最新热带病信息，中国。我们参观了曼谷Mahidol大学热带疾病医院，从与缅甸接壤的地区采集了1000份冰冻血液样本和10份新鲜PF血液样本。并对其临床资料进行了分析。血浆样本用于前列腺素分析，全血样本用于补体受体1(CR1)基因分析，以阐明疟疾严重程度的遗传因素。我们访问了曼谷、清迈和与缅甸接壤的地区，调查了泰国的疟疾情况，并采集了疟疾患者的血液样本(2000年12月)。我们参加了“第三届食源性人兽共患病研讨会暨国际热带医学联席会议”，收集了泰国疫情的最新信息，并在热带疾病医院采集了1500份疟疾患者和甲型流感患者的血液样本及其临床数据。我们走访了清迈卫生科学研究所、清迈大学和疟疾中心，调查了泰国北部的性病情况。大多数来自缅甸的难民都感染了疟疾寄生虫。我们参观了位于好邑的疟疾控制中心，并于近日落户热带医学培训中心，调查缅甸附近地区的疟疾情况。缅甸约90%的避难所感染了疟疾寄生虫。采集的血浆样本用于前列腺素分析。用噬菌体展示法检测部分血浆标本中的疟疾抗原，应用于疟疾诊断。采用全血标本进行CR1基因分析。

We visited Thailand and Sanya at the Hainan Island, China to investigate severe falciparum malaria (SM) situations at South Asia and to obtain blood samples from normal adults (NA) and falciparum malaria patients (Pf)(December 1999). We attended "the Second International Meeting on Tropical Diseases" to collect the latest information on SM at the island and South China. We visited Hospital for Tropical Diseases, Mahidol University at Bangkok and gained 1,000 frozen blood samples from and NA and Pf, and 10fresh Pf blood at an area bordering Myanmar. Their clinical data were also obtained. The plasma samples were used for prostanoid analysis and the whole blood samples were used complement receptor 1 (CR1) gene analysis to clarify genetic factor for malaria severity.We visited Bangkok, Chiang Mai and areas bordering Myanmar to investigate malaria situation at Thailand and to gain blood samples of malaria patients (December of 2000). We attended "The Third Symposium on Food-Borne Zoonoses and Joint International Tropical Medicine Meeting" to collect the latest information on SM situation on Thailand and gained 1,500 blood samples of malaria patients and NA and their clinical data at Hospital for Tropical Diseases. We visited the Institute of Health Science, Chang Mai University and Malaria Center at Chiang Mai to investigate SM situation at north Thailand. Most of refugees from Myanmar were infected with malaria parasites. We visited the Malaria Control Center at Haoyai and recently settled Training Center for Tropical Medicine to investigate malaria situation at near Myanmar areas. About 90% of refuges from Myanmar were infected with malaria parasites. The collected plasma samples were used for prostanoid analysis. A part of plasma samples were used for detection of malaria antigen with the use of phage display method to apply to malaria diagnosis. The whole blood samples were used for CR1 gene analysis.