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Nerve induction on the Titanium implant coated by essential trace elements

涂有必需微量元素的钛植入物上的神经感应

基本信息

批准号：
12470416
负责人：
KOBAYASHI Hiroshi
金额：
$ 7.04万
依托单位：
NIIGATA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

This study was designed for the basic study to add sensory functions on the Titanium Dental Implants. In the first stage we made the cell cultivating experiments. But we couldn't establish technique to make a suitable coat upon Titanium surface. In the second stage, we made mechanical structure analysis and searched for the structural requirements of the existence of neural fibers.1. Cell cultivation : we used PC12 cell that have origin of the brown cell of adrenal medulla in rat. We cultivated the cell in the cultivating dishes coated by gold (Au). The result was that the PC12 cells would not glow with gold.2. Essential trace elements : We tried to add essentiol elements on the surface of Titanium using Ion-spattering method and others. But it became clear that the specimen were not suitable for this experiment.3. Analysis of the mechanical structure : We made a mechanical model for the structure with implant and bone using Finite Element Method. In the result, it was concluded that the place that shows the largest displacement is separated area from the implant body. This shows that it is more effective for the mechanical sensor not to be attached to the implant. The total energy density also was the maximal value in the place 2.5-5.0mm below the bottom of the implant.4. Structural requirements : It is necessary to be deformed by the force for neural cell to detect any force in sensory receptors. By the results of this study, the force sensory receptors will be more efficient in separated place than in attached place to the implant. In the state of Osseous integration, if the sensory receptors exist in the border between the bone and the implant, the detective potential for the force will be low.

本研究旨在为钛种植体增加感觉功能的基础研究。第一阶段进行细胞培养实验。但我们不能建立技术，使一个合适的涂层钛表面。第二阶段，进行机械结构分析，寻找神经纤维存在的结构要求.细胞培养：采用大鼠肾上腺髓质棕色细胞来源的PC 12细胞。我们将细胞培养在涂有金（Au）的培养皿中。结果是PC 12细胞不会发出金色光芒。2.必需微量元素：我们尝试用离子溅射等方法在钛表面添加必需微量元素。但很明显，标本不适合这个实验。力学结构分析：采用有限元法建立了种植体-骨结构的力学模型。结果得出结论，显示最大位移的位置是与植入物主体分离的区域。这表明，机械传感器不连接到植入物上更有效。总能量密度在种植体底部以下2.5-5.0mm处最大.结构要求：神经细胞感受感受器中的任何力都需要在力的作用下变形。根据本研究的结果，力觉感受器在分离位置比在附着位置更有效。在骨结合状态下，如果感觉感受器存在于骨与种植体的交界处，则对力的探测电位较低。