Creation of Biologically relevant Supramolecular Chemistry and New Functional Materials

生物相关超分子化学和新型功能材料的创造

• 批准号: 12470479
• 负责人: KIMURA Eiichi
• 金额: $ 10.43万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470479/
• 关键词: Macrocyclic Compound; Supermolecule; Self-assembly; Multinuclear Zn Complex; double-stranded DNA; double-stranded RNA; anti-HIV agent; Gene expression; 大環状化合物; DNA人工フォトリアーゼ

1) Synthesis of Bioactive or Catalytic Macrocyclic Compounds :We have discovered new antiHIV agents and revealed their antiHIV mechanism. On the basis of our accumulated knowledge, new types of macrocyclic structures have been developed.2) Creation of Self-assembling Supermolecules with Multinuclear Macrocyclic Complexes :We have discovered that a trinuclear Zn^<2+> complex and cyanuric acid bind pH-dependently to yield 2 : 3 and 4 : 4 cubic supermolecules. In the central hollow, adamantane and other lipophilic molecules are enclosed.3) Evolution of Macrocyclic Chemistry to Genetic Sciences :We have developed macrocyclic complexes that control gene expression by exclusively binding to double-stranded DNA and RNA.

1）生物活性或催化大环化合物的合成：我们发现了新的抗HIV药物并揭示了其抗HIV机制。在我们积累的知识的基础上，新型的大环结构已经被开发出来。2）用多核大环配合物创建自组装超分子：我们发现三核Zn^<2+>配合物和氰尿酸依赖pH值结合产生2:3和4:4立方超分子。在中心空心处，封闭着金刚烷和其他亲脂性分子。3）大环化学向遗传科学的演变：我们开发了通过专门结合双链DNA和RNA来控制基因表达的大环复合物。

项目成果

S.Aoki et al.: "A Double-Functionalized Cyclen with Carbamoyl and Dansyl Groups(Cyclen=1,4,7,10-Tetraazacyclododecane) : A Selective Fluorescent Probe for Y^<3+> and La^<3+>"J. Am. Chem. Soc.. 123(6). 1123-1132 (2001)

S.Aoki 等人：“具有氨基甲酰基和丹酰基的双官能化 Cyclen（Cyclen=1,4,7,10-四氮杂环十二烷）：Y^<3> 和 La^<3> 的选择性荧光探针”J

S.Aoki et al.: "Recent Progress in Artificial Receptors for Phosphate Anions in Aqueous Solution"Recent Reviews in Molecular Biotechnology. (in press). (2002)

S.Aoki 等人：“水溶液中磷酸根阴离子人工受体的最新进展”分子生物技术的最新评论。

E.Kimura et al.: "Effects of bis (aromatic) pendents on recognition of Nucleobase thymine by Zn^<2+>-1,4,7,10-tetraazacyclodoclecane"J. Supramol. Chem.. (in press). (2002)

E.Kimura 等人：“双（芳香族）悬垂物对 Zn^2>-1,4,7,10-四氮杂环十二烷识别核碱基胸腺嘧啶的影响”J.

E. Kikuta, S. Aoki, E. Kimura: "New Potent Agents Binding to Poly(dT) Sequence in Double-Stranded DNA : Bis (Zn^<2+>-cyclen) and Tris (Zn^<2+>-cyclen) Complexes"J. Biol. Inorg. Chem. (Published online : 15 January). (2002)

E. Kikuta、S. Aoki、E. Kimura：“与双链 DNA 中的 Poly(dT) 序列结合的新有效药物：Bis (Zn^<2 >-cyclen) 和 Tris (Zn^<2 >-cyclen)

S.Aoki et al.: "A Cubotahedral Supramolecular Capsule by 4:4 Assembly of Tris (Zn^<2+>-Cyclen) and Trianionic Trithiocyanurate in Neutral pH Aqueous Solution"Chem.Eru.J.. 8. 829-839 (2002)

S.Aoki 等人：“在中性 pH 水溶液中通过 Tris (Zn^2-Cyclen) 和三阴离子三硫氰尿酸盐 4:4 组装形成立方体超分子胶囊”Chem.Eru.J.. 8. 829-839 (