Creation of Intelligent and Robotic Molecules with Macrocyclic Polyamines

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1. Novel macrocyclic polyamine-Zn^<II> complexes were synthesized, which selectively recognize thymine (or uracil) among all the nucleobases. The recognition mechanism was elucidated, which was successfully applied to a biochemical control of "protein synthesis".2. New macrocyclic polyamines possessing a dimer structure showed potent antiAIDS activities.3. New macrocyclic polyamine-gold complexes were synthesized, which have a high potential as novel, pollution-free gold-plating agents.4. A number of macrocyclic polyamine complexes having an electron-pool function were synthesized, which catalyze CO_2 reduction.5. New macrocyclic polyamines appended with an alcoholic group were synthesized, which were shown to be the first alkaline phosphatase model.