Creation of Intelligent and Robotic Molecules with Macrocyclic Polyamines

用大环多胺创造智能和机器人分子

• 批准号: 04403024
• 负责人: KIMURA Eiichi
• 金额: $ 21.7万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04403024/
• 关键词: Macrocyclic Polyamine; Intelligent Molecule; Artificial Enzyme; Zinc Enzyme; Anti-AIDS Drug; CO_2 Fixation Catalyst; Nucleic Acid Recognition; Gold Plating Agent; 蛋白合成阻害; 炭酸脱水酵素; アルコール脱水酵素; DNA高次構造変換

1. Novel macrocyclic polyamine-Zn^<II> complexes were synthesized, which selectively recognize thymine (or uracil) among all the nucleobases. The recognition mechanism was elucidated, which was successfully applied to a biochemical control of "protein synthesis".2. New macrocyclic polyamines possessing a dimer structure showed potent antiAIDS activities.3. New macrocyclic polyamine-gold complexes were synthesized, which have a high potential as novel, pollution-free gold-plating agents.4. A number of macrocyclic polyamine complexes having an electron-pool function were synthesized, which catalyze CO_2 reduction.5. New macrocyclic polyamines appended with an alcoholic group were synthesized, which were shown to be the first alkaline phosphatase model.

1。合成了新型的大环多胺-Zn^<ii>复合物，它们在所有核碱基中有选择地识别胸腺嘧啶（或尿嘧啶）。阐明了识别机制，该机制成功地应用于“蛋白质合成”的生化控制.2。具有二聚体结构的新的大环聚胺显示出有效的抗抗活性。3。合成了新的大环多胺复合物，它们具有很高的潜力，如新颖的无污染的镀金剂。4。合成了许多具有电子池函数的大环的多胺复合物，它们催化CO_2还原5。合成了含着酒精类的新的大环聚胺，这被证明是第一个碱性磷酸酶模型。

项目成果

E.Kimura: "Kinetic and Mechanism of the Hydration of Carbon Dioxide and Dehydration of Bicarbonate Catalyzed by a Zn(II)Complex of 1,5,9-Triazacyclododecane as a Model for Carbonic Anhydrase" Inorg.Chem. 32. 5749-5755 (1993)

E.Kimura：“1,5,9-三氮杂环十二烷的 Zn(II) 配合物作为碳酸酐酶模型催化二氧化碳水合和碳酸氢盐脱水的动力学和机制”Inorg.Chem。

E.Kimura, Y.Kurogi, T.Koike, M.Shionoya, Y.Iitaka: ""Gold (III) -cyclam Complexes. X-ray Crystal Structure and A Useful Macrocyclic Effect on the Reduction of Gold (III)"" J.Coord.Chem.28. 33-49 (1993)

E.Kimura、Y.Kurogi、T.Koike、M.Shionoya、Y.Iitaka：“”金（III）-仙客来复合物。

E.Kimura.H.Kurosaki,Y.Kurogi,M.Shionoya,and M.Shiro: "pH-Dependent Coordination Mode of New Bleomycin Synthetic Analogues with Copper(II),Iron(II),and Zinc(II)." Inorg.Crem.31. 4314-4321 (1992)

E.Kimura.H.Kurosaki、Y.Kurogi、M.Shionoya 和 M.Shiro：“新型博莱霉素合成类似物与铜 (II)、铁 (II) 和锌 (II) 的 pH 依赖性配位模式。”

Mitsuhiko Shionoya: "A New Ternary Zinc(II)Complex with〔12〕aneN_4 and AZT.Highly Selective Recognition of Thymidine and Its Related Nucleosides by Zinc(II)Macrocyclic Tetraamine Complex with Novel Complementary Associations" the Journal of the American Ch

Mitsuhiko Shionoya：“A New Tternary Zinc(II)Complex with〔12}aneN_4 and AZT.Highly Selective Recognition of Thymidine and Itlated Nucleosides by Zinc(II)Macrocycl Tetraamine Complex with Novel Complementary Associations”美国化学杂志

M.Shionoya: "Novel “Multipoint"Molecular Recognition of Nucleobases by a New Zinc(II)Complex of Acridine-Pendant Cyclen(Cyclen=1,4,7,10-Tetraazacyclododecane)." J.Am.Chem.Soc.116. 3848-3859 (1994)

M.Shionoya：“新型吖啶-悬垂 Cyclen 锌 (II) 复合物对核碱基的新型“多点”分子识别（Cyclen=1,4,7,10-四氮杂环十二烷）。”J.Am.Chem.Soc.116。 .3848-3859 (1994)