Creation of Intelligent and Robotic Molecules with Macrocyclic Polyamines

用大环多胺创造智能和机器人分子

• 批准号: 04403024
• 负责人: KIMURA Eiichi
• 金额: $ 21.7万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04403024/
• 关键词: Macrocyclic Polyamine; Intelligent Molecule; Artificial Enzyme; Zinc Enzyme; Anti-AIDS Drug; CO_2 Fixation Catalyst; Nucleic Acid Recognition; Gold Plating Agent; 蛋白合成阻害; 炭酸脱水酵素; アルコール脱水酵素; DNA高次構造変換

1. Novel macrocyclic polyamine-Zn^<II> complexes were synthesized, which selectively recognize thymine (or uracil) among all the nucleobases. The recognition mechanism was elucidated, which was successfully applied to a biochemical control of "protein synthesis".2. New macrocyclic polyamines possessing a dimer structure showed potent antiAIDS activities.3. New macrocyclic polyamine-gold complexes were synthesized, which have a high potential as novel, pollution-free gold-plating agents.4. A number of macrocyclic polyamine complexes having an electron-pool function were synthesized, which catalyze CO_2 reduction.5. New macrocyclic polyamines appended with an alcoholic group were synthesized, which were shown to be the first alkaline phosphatase model.

1.合成了能选择性识别胸腺嘧啶(或尿嘧啶)的新型大环多胺-锌、尿嘧啶的配合物。阐明了识别机制，并成功地应用于蛋白质合成的生化控制。具有二聚体结构的新型大环多胺具有较强的抗艾滋病活性。合成了新型大环多胺-金络合物，具有作为新型、无污染镀金剂的潜力。合成了一系列具有电子池功能的大环多胺配合物，它们催化CO_2还原。合成了新的添加了醇基的大环多胺，这是第一个碱性磷酸酶模型。

项目成果

E.Kimura.H.Kurosaki,Y.Kurogi,M.Shionoya,and M.Shiro: "pH-Dependent Coordination Mode of New Bleomycin Synthetic Analogues with Copper(II),Iron(II),and Zinc(II)." Inorg.Crem.31. 4314-4321 (1992)

E.Kimura.H.Kurosaki、Y.Kurogi、M.Shionoya 和 M.Shiro：“新型博莱霉素合成类似物与铜 (II)、铁 (II) 和锌 (II) 的 pH 依赖性配位模式。”

E.Kimura: "Kinetic and Mechanism of the Hydration of Carbon Dioxide and Dehydration of Bicarbonate Catalyzed by a Zn(II)Complex of 1,5,9-Triazacyclododecane as a Model for Carbonic Anhydrase" Inorg.Chem. 32. 5749-5755 (1993)

E.Kimura：“1,5,9-三氮杂环十二烷的 Zn(II) 配合物作为碳酸酐酶模型催化二氧化碳水合和碳酸氢盐脱水的动力学和机制”Inorg.Chem。

E.Kimura, Y.Kurogi, T.Koike, M.Shionoya, Y.Iitaka: ""Gold (III) -cyclam Complexes. X-ray Crystal Structure and A Useful Macrocyclic Effect on the Reduction of Gold (III)"" J.Coord.Chem.28. 33-49 (1993)

E.Kimura、Y.Kurogi、T.Koike、M.Shionoya、Y.Iitaka：“”金（III）-仙客来复合物。

Mitsuhiko Shionoya: "A New Ternary Zinc(II)Complex with〔12〕aneN_4 and AZT.Highly Selective Recognition of Thymidine and Its Related Nucleosides by Zinc(II)Macrocyclic Tetraamine Complex with Novel Complementary Associations" the Journal of the American Ch

Mitsuhiko Shionoya：“A New Tternary Zinc(II)Complex with〔12}aneN_4 and AZT.Highly Selective Recognition of Thymidine and Itlated Nucleosides by Zinc(II)Macrocycl Tetraamine Complex with Novel Complementary Associations”美国化学杂志

Y.Inouye: "Inhibition of Human Immunodeficiency Virus Proliferation by Macrocyclic Polyamines and Their Metal Complexes." Biol.Pham.Bull.17. 243-250 (1994)

Y.Inouye：“大环多胺及其金属配合物抑制人类免疫缺陷病毒的增殖。”