Preparation of Titania Gel Film with Graded Ca ion Distribution by Electrochemical Technique and Providing Titanium for Bone Substitution with High Bioactivity

电化学技术制备Ca离子梯度分布二氧化钛凝胶膜并为骨替代提供高生物活性钛

• 批准号: 12558109
• 负责人: OSAKA Akiyoshi
• 金额: $ 6.53万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12558109/
• 关键词: Osteoinduction; Titania; cathode polarization; Titanium; Bioactivity; calcium ion; Calcium Carbonate; anode oxidation; チタニアゲル; 細胞適合性; カルシウム

Titanium was oxidized with H_2O_2 aqueous solutions, simple heating in the air, and anode polarization to yield titanium oxide layers. Ability of those layers to induce biomimetic apatite deposition in a simulated body fluid was evaluated by X-ray diffractometry and scanning electron microscopy. Heating in air at temperatures in the range 200 to 700℃ yielded the oxide layers with little ability. The treatment with 30 mass% H_2O_2 solutions was similarly almost ineffective for biomimetic apatite deposition, but the subsequent heating at 300 to 700℃ in air significantly improved the ability. Such enhancement was attributed to an epitaxial induction of apatite nucleation caused by the precipitation of anatase on heating. Addition of Ta(V) in a few mmol/l caused a moderate positive effect. The oxide layers derived from anode oxidation at 9.5 V vs. Ag/AgCl followed by the anode oxidation. The cathode polarization deposited calcium ions as calcium hydroxide. Calcium carbonate was yielded from the hydroxide when soaked in the simulated body fluid, and provided the site of apatite nucleation as well as it was exhausted by the formation of apatite.

采用H_2O_2水溶液、空气中简单加热和阳极极化的方法对钛进行氧化，得到钛氧化物层。这些层诱导仿生磷灰石沉积在模拟体液中的能力进行了评估，通过X射线衍射法和扫描电子显微镜。在200 ~ 700℃的空气中加热，得到的氧化层几乎没有能力。用30mass%H_2O_2溶液处理对仿生磷灰石沉积同样几乎无效，但随后在空气中300 ~ 700℃加热显著提高了仿生磷灰石沉积的能力。这种增强归因于磷灰石成核的外延诱导所造成的沉淀的SiO2加热。添加几mmol/l的Ta（V）引起中等的正效应。氧化物层来源于在9.5V（相对于Ag/AgCl）下的阳极氧化，随后是阳极氧化。阴极极化使钙离子以氢氧化钙的形式沉积。氢氧化物在模拟体液中浸泡后生成碳酸钙，并为磷灰石的成核提供了场所，同时碳酸钙也因磷灰石的形成而耗尽。

项目成果

"Porous Titania Films Prepared from Interactions of Titanium with Hydrogen Peroxide Solution"Scripta Materialia. 46[1]. 101-106 (2002)

“通过钛与过氧化氢溶液的相互作用制备的多孔二氧化钛薄膜”Scripta Materialia。

Akiyoshi Osaka et al.: "In Vitro Biomimetic Deposition of Apatite on Chemically and Electrochemically Treated Titanium"Journal of Australian Ceramic Society. 37・1. 1-8 (2001)

Akiyoshi Osaka 等人：“磷灰石在化学和电化学处理的钛上的体外仿生沉积”，澳大利亚陶瓷学会杂志 37・1（2001 年）。

川辺 康弘 他: "金属チタン表面の高生体活性化"化学工業. 52・5. 21-25 (2001)

Yasuhiro Kawabe 等：“金属钛表面的高生物活性”化学工业 52・5（2001 年）。

"A comparative study of in vitro apatite deposition on beat-, H_2O_2, and NaOH-treated titanium surfaces"Journal of Biomedical Materials Research. Vol. 54. 172-178 (2001)

“在beat-、H_2O_2和NaOH处理的钛表面上体外磷灰石沉积的比较研究”生物医学材料研究杂志。

Akiyoshi Osaka: "Biomimetic Deposition of Apatite on Electrochemically Oxidized Titanium Substrates"13th international Symposium on Ceramics in Medicine, Bioceramics. 13. 263-266 (2000)

Akiyoshi Osaka：“磷灰石在电化学氧化钛基底上的仿生沉积”第十三届国际医学陶瓷研讨会，生物陶瓷。