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Bioactivity of materials provided by ultrasonic implantation

超声波植入提供的材料的生物活性

基本信息

批准号：
06555186
负责人：
OSAKA Akiyoshi
金额：
$ 3.78万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

Ultrasonic implantation technique was employed to provide biocompatible substrates with bioactivity where a suspension of a bioactive glass was agitated by an ultrasonic energy to implent the glass particles into the substrate surfaces.a.CaSiO_3 glass into poly (methyl methacrylate) (PMMA) substratesThe ultrasonic vibration could implant the bioactive CaSiO_3 glass particles into the surface in microscopic inhomogeneity when suspended in an optimum suspending solution 40THF-60ethanol. The inhomogeneity was considered to be caused by inhomogeneously distribution of the ultrasonic energy. In the intensified region four layrs were found on the substrate : the glass particles (40mum) -PMMA (60mum) -glass particles (40mum) -PMMA.In the lesser energy region two layrs were observed : glass particles (40mum) -PMMA.In either regions the PMMA on the utmost surface had lower density hence the simulated body fluid (Kokubo solution) used could go through the layr to be involved in apatite formation on the glass particles.b.CaSiO_3 glass into sillicone rubber substratesWe could not find such an optimum solvents that can swell up the surface of sillicone rubber and thus employed a set of two precursors for silicone that vulcanize at the room temperature. On the way of gelation after mixing the two liquids the ultrasonic inplantation was carried out with CaSiO_3 glass particles suspended ethanol. Homogeneous implantation of the glass was observed as well as the deposition of an apatite layr when the implanted substrate was soaked in the SBF for only a day. The suspensions of sol-gel derived silica particles and fumed silica colloid could be ultrasonically implanted but the apatite layr could not deposit on the substrates. This was attributed to the biocompatible character of those particles.

采用超声植入技术，通过超声能量搅拌生物活性玻璃悬浮液，将玻璃颗粒植入基底表面，从而提供具有生物活性的生物相容性基底。a.将CaSiO_3玻璃植入聚乙烯中超声振动可以将具有生物活性的CaSiO_2植入到聚甲基丙烯酸甲酯（PMMA）基体中。3.玻璃颗粒悬浮在40 THF-60乙醇的最佳悬浮液中时，进入表面的微观不均匀。这种不均匀性被认为是由超声能量的不均匀分布引起的。在增强区域中，在基底上发现四个层：玻璃颗粒（40 μ m）-PMMA（60 μ m）-玻璃颗粒（40 μ m）-PMMA。玻璃颗粒（40 μ m）-PMMA。在这两个区域中，最表面的PMMA密度较低，因此模拟体液所使用的CaSiO_2（Kokubo溶液）可以穿过层以参与在玻璃颗粒上形成磷灰石。我们找不到能使硅橡胶表面溶胀的最佳溶剂，因此采用了一组两种前体，在室温下硫化硅树脂。在两种液体混合后的凝胶化过程中，用CaSiO_3玻璃颗粒悬浮乙醇进行超声植入。当植入的基底在SBF中仅浸泡一天时，观察到玻璃的均匀植入以及磷灰石层的沉积。溶胶-凝胶法制备的二氧化硅颗粒和气相二氧化硅胶体的悬浮液可以进行超声注入，但磷灰石层不能存款在基体上。这归因于这些颗粒的生物相容性。