Bioactivity of materials provided by ultrasonic implantation

采用超声波植入技术，通过超声波能量搅动生物活性玻璃悬浮液，将玻璃颗粒植入基材表面，从而为生物相容性基材提供生物活性。a.CaSiO_3玻璃植入聚甲基丙烯酸甲酯(PMMA)基材中，当生物活性CaSiO_3玻璃颗粒悬浮在最佳悬浮液40THF-60乙醇中时，超声振动可以将生物活性CaSiO_3玻璃颗粒以微观不均匀性植入基材表面。不均匀性被认为是由超声波能量分布不均匀引起的。在增强区域中，在基板上发现四层：玻璃颗粒（40mum）-PMMA（60mum）-玻璃颗粒（40mum）-PMMA。在较小能量区域中，观察到两层：玻璃颗粒（40mum）-PMMA。在任一区域中，最表面上的PMMA密度较低，因此使用的模拟体液（Kokubo溶液）可以穿过该层，参与玻璃上磷灰石的形成。 b.CaSiO_3玻璃到硅橡胶基材中我们找不到能够使硅橡胶表面膨胀的最佳溶剂，因此采用了一组在室温下硫化的有机硅前体。在两种液体混合后的凝胶化过程中，用悬浮乙醇的CaSiO_3玻璃颗粒进行超声注入。当植入的基板仅在SBF中浸泡一天时，观察到玻璃的均匀植入以及磷灰石层的沉积。溶胶-凝胶衍生的二氧化硅颗粒和气相二氧化硅胶体的悬浮液可以超声植入，但磷灰石层不能沉积在基材上。这归因于这些颗粒的生物相容性。

Ultrasonic implantation technique was employed to provide biocompatible substrates with bioactivity where a suspension of a bioactive glass was agitated by an ultrasonic energy to implent the glass particles into the substrate surfaces.a.CaSiO_3 glass into poly (methyl methacrylate) (PMMA) substratesThe ultrasonic vibration could implant the bioactive CaSiO_3 glass particles into the surface in microscopic inhomogeneity when suspended in an optimum suspending solution 40THF-60ethanol. The inhomogeneity was considered to be caused by inhomogeneously distribution of the ultrasonic energy. In the intensified region four layrs were found on the substrate : the glass particles (40mum) -PMMA (60mum) -glass particles (40mum) -PMMA.In the lesser energy region two layrs were observed : glass particles (40mum) -PMMA.In either regions the PMMA on the utmost surface had lower density hence the simulated body fluid (Kokubo solution) used could go through the layr to be involved in apatite formation on the glass particles.b.CaSiO_3 glass into sillicone rubber substratesWe could not find such an optimum solvents that can swell up the surface of sillicone rubber and thus employed a set of two precursors for silicone that vulcanize at the room temperature. On the way of gelation after mixing the two liquids the ultrasonic inplantation was carried out with CaSiO_3 glass particles suspended ethanol. Homogeneous implantation of the glass was observed as well as the deposition of an apatite layr when the implanted substrate was soaked in the SBF for only a day. The suspensions of sol-gel derived silica particles and fumed silica colloid could be ultrasonically implanted but the apatite layr could not deposit on the substrates. This was attributed to the biocompatible character of those particles.