Synthesis of bone-bonding organic-inorganic composite derived from organic silicon compounds

植入材料要求与周围组织具有高度的生物相容性，并具有与被替代组织相适应的机械性能。本研究旨在通过溶胶-凝胶法制备结构中含有硅醇基和钙离子的有机-无机分子复合材料，并用-C-C链或-CH3基团对其进行修饰。利用模拟体液对合成的复合材料的生物活性进行了研究。以乙烯基三甲氧基硅烷为原料合成生物活性有机-无机复合材料将聚合的乙烯基三甲氧基硅烷(H_2C=CH(SiOCH_3)_3：VTS-M)在乙醇-水溶液中或在含有Ca(CH_3COO)_2或Ca(NO_3)_2的乙醇-水-正硅酸乙酯(Si(OCH_2CH_3)_4：TEOS)溶液中进行水解，得到复合凝胶。由此合成的凝胶在模拟体液中沉积了磷灰石层，表明该类型的复合材料具有生物活性。聚二甲基硅氧烷与正硅酸乙酯合成生物活性有机-无机复合材料为了合成含-CH3基团的有机改性无机材料，将聚二甲基硅氧烷((Si(CH3)2O-)n：PDMS)与正硅酸乙酯在异丙醇、四氢呋喃和含Ca(NO3)2的蒸馏水中进行共聚，得到复合凝胶。以TEOS：PDMS：HCl：H_2O：Ca(NO_3)_2=1：1.67：0.05：3：0.05(摩尔比)合成的凝胶在1-7天内形成磷灰石层，而不含钙离子的凝胶则没有。磷灰石的形成能力受HCl和Ca(NO_3)_2用量的影响。这主要是由于钙离子从硅基质中溶解而容易形成硅醇基，因为钙离子在硅基质中的浓度应受合成条件的影响

Implant materials are reuqired to have high biocompatibility with the surrounding body tissues as well as methanical properties suitable with for those of tissue substituted. This study was focused on development of organic-inorganic molecular composites having silanol groups and calcium ion in their structures, which is modified with -C-C- chain or -CH_3 groups, through sol-gel processing. Bioactivity of the composites synthesized was investigated by using a simulated body fluid.1. Synthesis of bioactive organic-inorganic composite using vinyltrimethoxysilane as starting materialPolymerized vinyltrimethoxysilane (H_2C=CH (SiOCH_3) _3) : VTS-M) was hydrolyzed in ethanol-water solution or in ethanol-water-Tetraethyl Orthosilicate (Si (OCH_2CH_3) _4 : TEOS) solution which contains Ca (CH_3COO) _2 or Ca (NO_3) _2. The solutions were kept at 40ﾟC,to obtained composite gels. Thus synthesized gels deposited apatite layr in simulated body fluid, which indicates that this type of composite shows bioactivity.2. Synthesis of bioactive organic-inorganic composite from poly dimethylsiloxane and TEOSIn order to synthesize organically modified inorganic materials having -CH_3 groups, poly dimethylsiloxane ((Si (CH_3) _2O-) n : PDMS)) and TEOS were co-polymerized in the solution of 2-propanol and tetrahydrofuran and distillled water containing Ca (NO_3) _2. Thus solution was kept at room temperature to obtained composite gel. The obtained gel which is synthesized in composition of TEOS : PDMS : HCl : H_2O : Ca (NO_3) _2=1 : 1.67 : 0.05 : 3 : 0.05 (molar ratio) deposited apatite layr in 1-7 day whereas.gel free from calcium ion did not. The apatite forming ability was influenced by the amounts of HCl and Ca (NO_3) _2. This is attributed predominantly to the ease of silanol group formation due to dissolution of calcium ion from the silica matrix, because the concentration of calcium ion in silica matrix should be affected by the synthetic conditions