Tissue-bonding organic-inorganic polymer hybrids
组织粘合有机-无机聚合物杂化物
基本信息
- 批准号:11694162
- 负责人:
- 金额:$ 3.97万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:1999
- 资助国家:日本
- 起止时间:1999 至 2001
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We investigated some modifications for bioactive organic-inorganic hybrids derived from ploy(dimethylsiloxane) (PDMS,- (SiO(CH_3)_2)_n -), tetraethoxysilane (TEOS), Si (OC_2H_5)_4) and calcium nitrate (Ca(NO_3)_2・4H_2O). (1)Incorporation of TiO_2: PDMS-SiO_2-TiO_2 system couldn't deposit apatite under the simulated body fluid. (2)Porous ORMOSILs: Porous hybrids were prepared by using scurose particle as a porogen. The pore size could be controlled depending on the particle size of the porogen. Porosity of the hybrids was about 90%. The hybrids treated with CaCl_2 solution could deposit apatite within 3 days in the simulated body fluid and also show good cytocompatibility. (3)Hybrids reinforced with colloidal silica: The compressive strength increased by heating. According to dynamic mechanical properties of samples, storage modulus above -50℃ increased by heating. This is related to the increase of PDMS-silica interaction by heating.A new type of inorganic-organic hybrid materials incorporating gelatin and 3- (glycidoxypropy1) trimethoxysilane (GPSM) was prepared through sol-gel processing. (1)Gelatin-siloxane hybrids: GPSM molecules were grafted to the gelatin chains due to the reactions between the epoxy groups of GPSM and the nucleophilic active groups of gelatin. This process provides inorganic-organic hybrids in which the inorganic component of Si chemically bonded to natural polymer of gelatin with -Si-O-Si- bonds. (2)Incorporation of Ca^<2+>: Ca^<2+> containing gelatin-siloxane hybrids could deposit apatite within 3 days soaking in simulated body fluid. (3)Porous gelatin-siloxane hybrids: The porosity was introduced into these bulk gels by post-gelation soaking and by subsequent freeze-drying. The freezing temperature and pH value of the soaking solutions controlled the porosity and the pore size of the hybrids. The porous hybrids showed good bioactivity and cytocompatibility.
我们研究了由聚二甲基硅氧烷(PDMS,-(SiO(CH3)2)n-)、正硅酸乙酯(TEOS)、硅(OC_2H_5)_4和硝酸钙(Ca(NO_3)_2·4H_2O)衍生的生物活性有机-无机杂化材料的一些改性。(1)在模拟体液条件下,加入TiO2:PDMS-SiO_2-TiO_2体系不能沉积磷灰石。(2)多孔ORMOSILs:以硫糖颗粒为致孔剂制备多孔杂化材料。孔的大小可以根据造孔剂的颗粒大小进行控制。杂交种的孔隙率约为90%。用CaCl2溶液处理的杂交体在模拟体液中可在3d内沉积磷灰石,且具有良好的细胞相容性。(3)SiO_2胶体增强杂化材料的抗压强度随温度的升高而提高。从样品的动态力学性能来看,在-50℃以上的储能模数随加热而增加。这与加热增强了PDMS-二氧化硅的相互作用有关。通过溶胶-凝胶法制备了明胶和3-(缩水甘油氧丙基)三甲氧基硅烷(GPSM)复合的新型无机-有机杂化材料。(1)明胶-硅氧烷杂化:由于明胶的环氧基团与明胶的亲核活性基团发生反应,将明胶分子接枝到明胶链上。这一过程提供了无机-有机杂化材料,其中硅的无机成分通过-Si-O-Si-键化学结合到明胶的天然聚合物上。(2)掺入Ca~(2+)的明胶-硅氧烷杂化材料在模拟体液中浸泡3d即可沉积出磷灰石。(3)多孔明胶-硅氧烷杂化:通过凝胶后浸泡和随后的冷冻干燥将孔隙率引入到这些块状凝胶中。冻结温度和浸泡溶液的pH值控制了杂化材料的孔隙率和孔径。所制备的多孔杂交瘤细胞具有良好的生物活性和细胞相容性。
项目成果
期刊论文数量(42)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
T.Yabuta et al.: "Synthesis of PDMS-Based Porous Materials for Biomedical Applications"Journal of Sol-Gel Science and Technology. (in press).
T.Yabuta等人:“用于生物医学应用的基于PDMS的多孔材料的合成”溶胶-凝胶科学与技术杂志。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
L.Ren 他: "Synthesis and Charactaerization of Gelatin-Siloxane Hybrids Derived through Sol-Gel Procedure"J. Sol-Gel Soc.Technol.. 21. 115-121 (2001)
L. Ren 等人:“通过溶胶-凝胶程序衍生的明胶-硅氧烷杂化物的合成和表征”J. Sol-Gel Technol.. 21. 115-121 (2001)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
L. Ren et al.: "Incorporation of Ca^<2+> Ions in Gelatin-Siloxane Hybrids through a Sol-Gel Process"J. Ceram. Soc. Japan. 109[5]. 403-408 (2001)
L. Ren等人:“通过溶胶-凝胶过程在明胶-硅氧烷杂化物中掺入Ca 2+ 离子”J。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
L.Ren et al.: "Incorporation of Ca^<+2> Ions in Gelatin-Siloxane Hybrids through a Sol-Gel process"Journal of Ceramics Society Japan. 109・5. 403-408 (2001)
L.Ren等人:“通过溶胶-凝胶过程在明胶-硅氧烷杂化物中掺入Ca ^ +2 离子”日本陶瓷学会杂志109・5(2001)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
K.Tsuru 他: "Sol-Gel Derived Gelatin-Siloxane Hybrids"Proc.Inter.Symp.Mater.Sci. for the 21th Century (ISMS-21). 83-96 (2001)
K.Tsuru 等人:“溶胶-凝胶衍生的明胶-硅氧烷杂化物”Proc.Inter.Symp.Mater.Sci. for the 21st Century (ISMS-21)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
OSAKA Akiyoshi其他文献
OSAKA Akiyoshi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('OSAKA Akiyoshi', 18)}}的其他基金
Selective elimination of a specific component from alloys for providing bone-bonding ability
从合金中选择性消除特定成分以提供骨结合能力
- 批准号:
24650280 - 财政年份:2012
- 资助金额:
$ 3.97万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Preparation of Titania Gel Film with Graded Ca ion Distribution by Electrochemical Technique and Providing Titanium for Bone Substitution with High Bioactivity
电化学技术制备Ca离子梯度分布二氧化钛凝胶膜并为骨替代提供高生物活性钛
- 批准号:
12558109 - 财政年份:2000
- 资助金额:
$ 3.97万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mechanical property and bioactivity of organic-inorganic hybrid materials containing silanol groups
含硅烷醇基有机无机杂化材料的力学性能和生物活性
- 批准号:
09450246 - 财政年份:1997
- 资助金额:
$ 3.97万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Synthesis of bone-bonding organic-inorganic composite derived from organic silicon compounds
有机硅化合物衍生的骨粘合有机-无机复合材料的合成
- 批准号:
07680944 - 财政年份:1995
- 资助金额:
$ 3.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Bioactivity of materials provided by ultrasonic implantation
超声波植入提供的材料的生物活性
- 批准号:
06555186 - 财政年份:1994
- 资助金额:
$ 3.97万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Preparation of Fact-Ion Conductive Thin Films as nano-sized Battery Electrolytes
纳米级电池电解质 FF-Ion 导电薄膜的制备
- 批准号:
04650705 - 财政年份:1992
- 资助金额:
$ 3.97万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Preparation of Multi-layered Ceramic Particles
多层陶瓷颗粒的制备
- 批准号:
02650564 - 财政年份:1990
- 资助金额:
$ 3.97万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Bonding State of Halide ions and Properties of Oxyhaloborate, Silicate and Tellurite Glasses
卤化物离子的键合状态与卤硼酸盐、硅酸盐和亚碲酸盐玻璃的性能
- 批准号:
62550567 - 财政年份:1987
- 资助金额:
$ 3.97万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似国自然基金
中药复方“芍药甘草汤”活性成分的单克隆抗体制备及剔除分析法的建立
- 批准号:30572316
- 批准年份:2005
- 资助金额:28.0 万元
- 项目类别:面上项目
新功能肽Aglycin降低高血糖的机理和药理研究
- 批准号:30470823
- 批准年份:2004
- 资助金额:30.0 万元
- 项目类别:面上项目
相似海外基金
I-Corps: Translation Potential of Cellulose-Nanofiber-Based Surface Agents for Enhancing Bioactive Filtration Efficiency
I-Corps:纤维素纳米纤维基表面剂在提高生物活性过滤效率方面的转化潜力
- 批准号:
2401619 - 财政年份:2024
- 资助金额:
$ 3.97万 - 项目类别:
Standard Grant
Atomic-Scale Engineering of Bioactive Organic Molecules on Surfaces
表面生物活性有机分子的原子尺度工程
- 批准号:
DP240100464 - 财政年份:2024
- 资助金额:
$ 3.97万 - 项目类别:
Discovery Projects
Bioactive fragments of the extracellular matrix orchestrate lung epithelial cell repair.
细胞外基质的生物活性片段协调肺上皮细胞修复。
- 批准号:
BB/Y004183/1 - 财政年份:2024
- 资助金额:
$ 3.97万 - 项目类别:
Research Grant
Bioactive Effective Surface For Transport Network (BEST Network)
传输网络的生物活性有效表面(BEST网络)
- 批准号:
EP/X03576X/1 - 财政年份:2024
- 资助金额:
$ 3.97万 - 项目类别:
Research Grant
EBioAct: Environmentally sustainable production of bioactive triterpenes
EBioAct:生物活性三萜的环境可持续生产
- 批准号:
BB/Y007751/1 - 财政年份:2024
- 资助金额:
$ 3.97万 - 项目类别:
Research Grant
Mining the chemodiversity of the genus Myrica to reveal bioactive molecules for their medicinal uses
挖掘杨梅属的化学多样性,揭示其药用生物活性分子
- 批准号:
2880591 - 财政年份:2023
- 资助金额:
$ 3.97万 - 项目类别:
Studentship
Unlocking New Chemistries in Extant Enzymes for Synthesizing Bioactive Molecules
解锁现有酶中用于合成生物活性分子的新化学成分
- 批准号:
10784165 - 财政年份:2023
- 资助金额:
$ 3.97万 - 项目类别:
Accessing and Expanding Natural Products Chemical Diversity by Big-data Analysis and Biosynthetic Investigation
通过大数据分析和生物合成研究获取和扩大天然产物化学多样性
- 批准号:
10714466 - 财政年份:2023
- 资助金额:
$ 3.97万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 3.97万 - 项目类别:
Biology the initiator: Harnessing Reactive Oxygen Species for Biocompatible Polymerization
生物学引发者:利用活性氧进行生物相容性聚合
- 批准号:
10667740 - 财政年份:2023
- 资助金额:
$ 3.97万 - 项目类别: