Tissue-bonding organic-inorganic polymer hybrids

We investigated some modifications for bioactive organic-inorganic hybrids derived fromploy(dimethylsiloxane) (PDMS,- (SiO(ch_3)_2)_n -), tetraethoxysilane (TEOS)，Si (oc_2h_5)_4) and calcium nitrate (Ca(no_3)_2·4 h_2o). (1)Incorporation of tio_2：pdms - sio_2 - tio_2系统couldn't deposit apatite under the simulated body fluid. (2)Porous ORMOSILs：Porous hybrids prepared by using scurose particle as a porogen. The pore size could becontrolled depending on the particle size of the porogen. Porosity of the hybrids was约90%. thehybrids treated with cpl_2 solution could deposit apatite within 3 days in the simulated bodyfluid and also show good cytocompatibility. Hybrids reinforced with colloidal silica：compressive strength increased by heating. According to dynamic mechanical properties ofsamples,存储模块above -50℃increased by heating. This is related to the increase of PDMS-silicainteraction by heating.A new type of inorganic-organic hybrid materials incorporating gelatin and 3-（glycidoxypropy1） trimethoxysilane (GPSM) was prepared through sol-gel processing.(1) gelatin-siloxane hybrids:GPSM molecules grafted to the gelatin chains due to the reaction between the epoxy groups ofGPSM and the nucleophilic active groups of gelatin. This process provides inorganic-organic hybridsin which the inorganic component of Si chemically bonded to natural polymer of gelatin with-Si-O-Si- bonds. (2)Incorporation of Ca <2+>：Ca^<2+> containing gelatin-siloxane hybrids could deposit apatite within 3 days soaking in simulatedbody fluid. (3)Porous gelatin-siloxane hybrids：The porosity was introduced into these bulk gels by post-gelation soaking and by subsequentfreezing temperature and pH value of The soaking solutions controlled The freezing temperature and pH value of The solutions controlledporosity and the pore size of the hybrids. porous hybrids showed good bioactivity andcytocompatibility。

We investigated some modifications for bioactive organic-inorganic hybrids derived from ploy(dimethylsiloxane) (PDMS,- (SiO(CH_3)_2)_n -), tetraethoxysilane (TEOS), Si (OC_2H_5)_4) and calcium nitrate (Ca(NO_3)_2・4H_2O). (1)Incorporation of TiO_2: PDMS-SiO_2-TiO_2 system couldn't deposit apatite under the simulated body fluid. (2)Porous ORMOSILs: Porous hybrids were prepared by using scurose particle as a porogen. The pore size could be controlled depending on the particle size of the porogen. Porosity of the hybrids was about 90%. The hybrids treated with CaCl_2 solution could deposit apatite within 3 days in the simulated body fluid and also show good cytocompatibility. (3)Hybrids reinforced with colloidal silica: The compressive strength increased by heating. According to dynamic mechanical properties of samples, storage modulus above -50℃ increased by heating. This is related to the increase of PDMS-silica interaction by heating.A new type of inorganic-organic hybrid materials incorporating gelatin and 3- (glycidoxypropy1) trimethoxysilane (GPSM) was prepared through sol-gel processing. (1)Gelatin-siloxane hybrids: GPSM molecules were grafted to the gelatin chains due to the reactions between the epoxy groups of GPSM and the nucleophilic active groups of gelatin. This process provides inorganic-organic hybrids in which the inorganic component of Si chemically bonded to natural polymer of gelatin with -Si-O-Si- bonds. (2)Incorporation of Ca^<2+>: Ca^<2+> containing gelatin-siloxane hybrids could deposit apatite within 3 days soaking in simulated body fluid. (3)Porous gelatin-siloxane hybrids: The porosity was introduced into these bulk gels by post-gelation soaking and by subsequent freeze-drying. The freezing temperature and pH value of the soaking solutions controlled the porosity and the pore size of the hybrids. The porous hybrids showed good bioactivity and cytocompatibility.