A NOVEL SYNTHETIC ROUTE OF MOLECULARLY IMPRINTED POLYPYRROL FOR APPLICATION TO ELECTRONEUTRAL MOLECULES

近十年发展起来的分子印迹技术正在成为制备识别目标分子的人工聚合物的有力工具。我们将过氧化技术应用于聚吡咯(PPy)薄膜和胶体的制备，以评价该技术的识别性能。然而，这种方法的主要局限性是掺杂电荷，这意味着模板分子至少在聚合过程中必须是阴离子的。为了扩大目标分子的可能范围，还开发了一种使用阴离子类似模板的技术，并成功地利用该技术识别了电子中和或阳离子分子。在该项目中还开发了另一种消除上述限制的技术。人们关注的是一种分子识别系统，该系统在Ppy胶体中掺杂的牛磺胆酸盐阴离子胶束的疏水核心中形成了印迹有疏水氨基酸的空腔。该技术的重要改进是不再需要阴离子(模拟)模板。此外，胶束内精确形成的形状互补空腔为高效识别各种氨基酸的对映体提供了一条新颖而直接的合成路线。

Molecular imprinting techniques, which have developed during the last decade, are becoming a powerful tool for the preparation of artificial polymers that recognize target molecules. We have been applying the overoxidation technique for the preparation of polypyrrole (Ppy) films and colloids in order to evaluate the recognition performance of this technique. However, the main limitation of this approach has been the dopant charge, meaning that a template molecule must be anionic at least on polymerization.To extend the possible range of target molecules, a technique using anionic analog templates has also been developed, and electroneutral or cationic molecules were successfully recognized with this technique. Another technique to remove the above limitation was also developed in this project. Attention was directed to a molecular recognition system with a cavity imprinted with a hydrophobic amino acid, which has been created in the hydrophobic core of a taurocholate anionic micelle doped in Ppy colloids. The important improvement of this technique is that an anionic (analog) template is no longer required. Further, the precisely formed shape-complementary cavities within the micelles gave a novel and straightforward synthetic route to highly effective enantiorecognition towards various amino acids.