A NOVEL SYNTHETIC ROUTE OF MOLECULARLY IMPRINTED POLYPYRROL FOR APPLICATION TO ELECTRONEUTRAL MOLECULES

一种应用于电中性分子的分子印迹聚吡咯的新合成路线

• 批准号: 13440221
• 负责人: NAGAOKA Tsutomu
• 金额: $ 5.31万
• 依托单位: YAMAGUCHI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13440221/
• 关键词: overoxidized polypyrrole; conducting polymer; molecular imprinting; amino acid; recognition of enantiomers; micelle; colloid; high selectivity; 導電性高分子; 分子認識; コール酸; 過酸化ポリピロール; 光学異性体認識; コレステロール; センサー; 高選択性

Molecular imprinting techniques, which have developed during the last decade, are becoming a powerful tool for the preparation of artificial polymers that recognize target molecules. We have been applying the overoxidation technique for the preparation of polypyrrole (Ppy) films and colloids in order to evaluate the recognition performance of this technique. However, the main limitation of this approach has been the dopant charge, meaning that a template molecule must be anionic at least on polymerization.To extend the possible range of target molecules, a technique using anionic analog templates has also been developed, and electroneutral or cationic molecules were successfully recognized with this technique. Another technique to remove the above limitation was also developed in this project. Attention was directed to a molecular recognition system with a cavity imprinted with a hydrophobic amino acid, which has been created in the hydrophobic core of a taurocholate anionic micelle doped in Ppy colloids. The important improvement of this technique is that an anionic (analog) template is no longer required. Further, the precisely formed shape-complementary cavities within the micelles gave a novel and straightforward synthetic route to highly effective enantiorecognition towards various amino acids.

分子印迹技术是近十年来发展起来的一种新的分子印迹技术，它已成为制备识别目标分子的人工聚合物的有力工具。我们一直在应用过氧化技术制备聚吡咯（Ppy）薄膜和胶体，以评估这种技术的识别性能。然而，这种方法的主要限制是掺杂剂的电荷，这意味着模板分子必须是阴离子的至少在polymerization.To扩大目标分子的可能范围，使用阴离子类似物模板的技术也已开发，并成功地识别电中性或阳离子分子与这种技术。本项目还开发了另一种消除上述限制的技术。注意力被引导到一个分子识别系统的空腔印迹与疏水性氨基酸，这已被创建在疏水核心的牛磺胆酸钠阴离子胶束掺杂在Ppy胶体。该技术的重要改进是不再需要阴离子（类似物）模板。此外，胶束内精确形成的形状互补的空腔提供了一种新的和简单的合成路线，对各种氨基酸的高效对映体识别。

项目成果

H.Shiigi, K.Okamura, D.Kijima, A.Hionaka, B.Deore, U.Sree, T.Nagaoka: "Fabrication process and characterization of a novel structural isomer sensor. Molecularly imprinted overoxidized polypyrrole film"Electrochemical and Solid-State Letters. 6. H1-H3 (200

H.Shiigi、K.Okamura、D.Kijima、A.Hionaka、B.Deore、U.Sree、T.Nagaoka：“新型结构异构体传感器的制造工艺和表征。分子印迹过氧化聚吡咯薄膜”电化学与固体-

B.Deore, H.Yakabe, H.Shiigi, T.Nagaoka: "Enantioselective uptake of amino acids using an electromodulated column packed with carbon fibres modified with overoxidised polypyrrole"Analyst. 127. 935-939 (2002)

B.Deore、H.Yakabe、H.Shiigi、T.Nagaoka：“使用填充有过氧化聚吡咯改性碳纤维的电调制柱对氨基酸进行对映选择性摄取”分析师。

B.Deore, T.Nagaoka: "The direct electrochemical detection of amino acids at a Cu electrode in an acidic chromatographic effluent"Analytical Sciences. 17. i1691-i1694 (2001)

B.Deore、T.Nagaoka：“酸性色谱流出物中铜电极上氨基酸的直接电化学检测”分析科学。

H.Okuno, T.Kitano, H.Yakabe, M.Kishimoto, B.A.Deore, H.Shiigi, T.Nagaoka: "Characterization of overoxidized Polypyrrole colloids imprinted with L-lactate and their application to enantioseparation of amino acids"Analytical Chemistry. 74. 4184-4190 (2002)

H.Okuno、T.Kitano、H.Yakabe、M.Kishimoto、B.A.Deore、H.Shiigi、T.Nagaoka：“用 L-乳酸印迹的过氧化聚吡咯胶体的表征及其在氨基酸对映体分离中的应用”分析化学。

Z.Chen, K.Okamura, M.Hanaki, T.Nagaoka: "Selective Determination of Tryptophan by Using a Carbon Paste Electrode Modified with an Overoxidized Polypyrrole Film"Anal.Sci.. (印刷中).

Z.Chen、K.Okamura、M.Hanaki、T.Nagaoka：“使用过氧化聚吡咯薄膜修饰的碳糊电极选择性测定色氨酸”Anal.Sci..（出版中）。