Development of F-18 (positron emitter) labeled serotonin derivatives useful for the pathophysiology of depression.

正电子发射断层扫描（PET）是一种提供生理过程图像的分子成像技术。像F-18或C-11这样的正电子发射体具有能够对正电子发射的放射性药物进行精确和美观成像的特性。其中，葡萄糖的类似物FDG是最广泛使用的，因为它在大多数肿瘤中积累。然而，FDG也有缺点，如大脑或某些颗粒的生理吸收。FAMT是色氨酸的F-18标记衍生物，仅分布于脑肿瘤中，而不分布于正常大脑中，可用于脑肿瘤的定位或治疗后复发的诊断。据报道，血清素（5-HT）通过调节血清素转运体（5-HTT）与抑郁症有一定关系。在本研究中，我们试图可视化5-HTT在大脑中的分布，并合成了C-11标记的^<11>C-DASB (N，N-二甲基-2-（2-氨基-4-氰苯基硫）苄基胺^<11>C-DASB，这似乎对研究抑郁症的病理生理有帮助。

Positron emission tomography (PET) is a molecular imaging technique that provides images of physiological process. The positron emitters such as F-18 or C-11 have properties which permit accurate and beautiful imaging of positron-emitting radiopharmaceuticals. Among them, FDG, an analogue of glucose, is the most widely used, since it accumulates in the most tumors. However FDG has drawbacks, such as the physiological uptake in the brain or some granulations. FAMT, F-18 labeled derivative of tryptophan, distribute only in the brain tumor, but not in the normal brain, and is useful for the localization of brain tumor or the diagnosis of the recurrence after therapy. It is reported that serotonin (5-HT) has some relation with depression, by regulating the serotonin transporter (5-HTT).In the present study, we intended to visualize the brain distribution of 5-HTT and synthesized C-11 labeled ^<11>C-DASB (N,N-dimethyl-2-(2-amino-4-cyanophenylthio) benzyl-amine ^<11>C-DASB and seemed to be useful for studying the pathophysiology of depression.