The search for the cell marker of the cells that have a capacity to regenerate skin

寻找具有皮肤再生能力的细胞的细胞标记

• 批准号: 13470380
• 负责人: KISHI Kazuo
• 金额: $ 9.41万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470380/
• 关键词: fetal wound healing; regeneration; cell marker

Fetal wounds mede at some developmental stages regenerate quickly and completely. This regeneration could be the model of regeneration in mammals. We found that the embryonic dermal but not fascial mesenchymal cells play key roles in cutaneous regeneration. This project aimed to investigate the cell marker to distinguish cell marker to distinguish cells that have a capacity to regenerate skin. By using DNA microarray and immunohistochemistly, we found that integrin alphaV, and Rac-1 are expressed exclusively in fetal dermal mesenchymal cells. In the future these result will be useful to find out the cells that have a potent capacity to regenerate skin.

胎儿伤口在某些发育阶段会迅速而完全地再生。这种再生可能是哺乳动物再生的模式。我们发现胚胎真皮而不是筋膜间充质细胞在皮肤再生中起关键作用。本项目旨在研究细胞标记物，以区分细胞标记物，以区分具有再生皮肤能力的细胞。通过DNA芯片和免疫组织化学方法，我们发现整合素αV和RAC-1仅在胎儿真皮间充质细胞中表达。在未来，这些结果将有助于找出具有再生皮肤能力的细胞。

项目成果

貴志和生, 他: "Sonic hedgehogとscarless wound healingとの関係"Prog. In Mediicine. 22. (2003)

Kazuo Kishi 等人：“音速刺猬与无疤伤口愈合之间的关系”Prog。22。（2003）

Kishi K et al.: "The role of decorin in fetal wound healing"Wound Repair and Regeneration. 10, A8. (2002)

Kishi K等人：“核心蛋白聚糖在胎儿伤口愈合中的作用”伤口修复和再生。

貴志和生, 他: "骨格筋のtissue engineeringのチャレンジと展望"形成外科. 45(5). 419-424 (2002)

Kazuo Kishi 等人：“骨骼肌组织工程的挑战和前景”整形外科 45(5) 419-424 (2002)。

Kazuo Kishi, et al.: "The role of decorin in fetal wound healing"Wound Repair and Regeneration. 10(6). A8 (2002)

Kazuo Kishi 等人：“核心蛋白聚糖在胎儿伤口愈合中的作用”伤口修复和再生。

Kazuo Kishi et al.: "The role of decorin in fetal wound healing"Wund Repair and Regeneration. 10. A8 (2002)

Kazuo Kishi 等人：“核心蛋白聚糖在胎儿伤口愈合中的作用”伤口修复和再生。