Development of treatment method to inhibit progress of root surface caries-Evaluation of the effects of impregnation of antibacterial resin

在这个研究项目中，应用含抗菌单体MDPB的牙本质粘接系统（DBS）的效果本文通过体外实验研究了12-甲基丙烯酰氧十二烷基溴化吡啶对根面龋的抑制作用。MBC测定：2.含MDPB的抗菌引物的杀菌活性高于任何其他商业产品，用含4%MDPB的引物可完全杀灭脱矿牙本质中的细菌4.通过酸凝胶或变形链球菌培养技术产生的人工根龋病变的进展，含MDPB的DBS可完全阻止脱矿牙本质表面菌斑的形成。5.含MDPB的DBS可抑制脱矿牙本质表面菌斑的形成，应用含MDPB的粘结树脂时观察到强烈的抑制作用，这些结果表明MDPB-含有DBS的组合物可有效抑制根面龋的发展，并可能有益于治疗活动性根龋损伤。

In this research project, the effects of application of a dentin bonding system (DBS) containing the antibacterial monomer MDPB (12-methacryloyloxydodecylpyridinium bromide) on inhibition of progress of root surface caries were examined by in vitro studies.1.None of the proprietary DBS demonstrated significant antibacterial effects against oral bacteria when tested by agar-disc diffusion method and MIC/MBC determination.2.Bactericidal activities of antibacterial primers containing MDPB were greater than those of any other commercial products, and the application of 4% MDPB-containing primer resulted in complete killing of bacteria in demineralized dentine.3.MDPB-containing primers were capable of penetrating deeply into the artificial and natural carious lesions.4.The progression of artificial root carious lesions, produced by either an acid-gel or a Streptococcus mutans culture technique, was completely prevented by the application of MDPB-containing DBS.5.Plaque accumulation on the surface of the demineralized dentin was inhibited when MDPB-containing DBS was applied, strong inhibition being observed by the application of MDPB-containing bonding resin.These results indicate that MDPB-containing DBS is effective in inhibiting the progress of root surface caries and of possible benefit for managing active root carious lesions.