Development of treatment method to inhibit progress of root surface caries-Evaluation of the effects of impregnation of antibacterial resin

抑制根面龋病进展的治疗方法的开发-抗菌树脂浸渍效果评价

• 批准号: 13470402
• 负责人: IMAZATO Satoshi
• 金额: $ 10.37万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470402/
• 关键词: Adhesive systems; Root caries; older people; antibacterial activity; management; dentin primer; quaternary ammonium; artificial caries; レジン; 抗菌性プライマー; MDPB; ミニマムインターベンション

In this research project, the effects of application of a dentin bonding system (DBS) containing the antibacterial monomer MDPB (12-methacryloyloxydodecylpyridinium bromide) on inhibition of progress of root surface caries were examined by in vitro studies.1.None of the proprietary DBS demonstrated significant antibacterial effects against oral bacteria when tested by agar-disc diffusion method and MIC/MBC determination.2.Bactericidal activities of antibacterial primers containing MDPB were greater than those of any other commercial products, and the application of 4% MDPB-containing primer resulted in complete killing of bacteria in demineralized dentine.3.MDPB-containing primers were capable of penetrating deeply into the artificial and natural carious lesions.4.The progression of artificial root carious lesions, produced by either an acid-gel or a Streptococcus mutans culture technique, was completely prevented by the application of MDPB-containing DBS.5.Plaque accumulation on the surface of the demineralized dentin was inhibited when MDPB-containing DBS was applied, strong inhibition being observed by the application of MDPB-containing bonding resin.These results indicate that MDPB-containing DBS is effective in inhibiting the progress of root surface caries and of possible benefit for managing active root carious lesions.

在这个研究项目中，应用含抗菌单体MDPB的牙本质粘接系统（DBS）的效果本文通过体外实验研究了12-甲基丙烯酰氧十二烷基溴化吡啶对根面龋的抑制作用。MBC测定：2.含MDPB的抗菌引物的杀菌活性高于任何其他商业产品，用含4%MDPB的引物可完全杀灭脱矿牙本质中的细菌4.通过酸凝胶或变形链球菌培养技术产生的人工根龋病变的进展，含MDPB的DBS可完全阻止脱矿牙本质表面菌斑的形成。5.含MDPB的DBS可抑制脱矿牙本质表面菌斑的形成，应用含MDPB的粘结树脂时观察到强烈的抑制作用，这些结果表明MDPB-含有DBS的组合物可有效抑制根面龋的发展，并可能有益于治疗活动性根龋损伤。

项目成果

Imazato S, et al.: "Antibacterial activity and bonding characteristics of an adhesive resin containing antibacterial monomer MDPB"Dental Materials. 19(4). 313-319 (2003)

Imazato S 等人：“含有抗菌单体 MDPB 的粘合树脂的抗菌活性和粘合特性”牙科材料。

Imazato S, et al.: "Antibacterial properties of resin composites and dentin bonding systems"Dental Materials. (印刷中). (2003)

Imazato S 等人：“树脂复合材料和牙本质粘合系统的抗菌性能”牙科材料（2003 年出版）。

Imazato S, et al.: "Antibacterial properties of resin composites and dentin bonding systems."Dental Materials. 19(6). 449-457 (2003)

Imazato S 等人：“树脂复合材料和牙本质粘合系统的抗菌性能。”牙科材料。

Chan K, et al.: "Bonding of mild self-etching primers/adhesives to dentin with thick smear layers."American Journal of Dentistry. 16(5). 340-346 (2003)

Chan K 等人：“将温和的自酸蚀底漆/粘合剂与厚涂片层的牙本质粘合。”美国牙科杂志。

Imazato S, Kuramoto A, Ehara A, Kaneko T, Ebisu S, Russell RRB: "Comparison of antibacterial activity of simplified adhesive systems"American Journal of Dentistry. (印刷中). (2002)

Imazato S、Kuramoto A、Ehara A、Kaneko T、Ebisu S、Russell RRB：“简化粘合剂系统的抗菌活性比较”美国牙科杂志（2002 年出版）。