Development of treatment method to inhibit progress of root surface caries-Evaluation of the effects of impregnation of antibacterial resin

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In this research project, the effects of application of a dentin bonding system (DBS) containing the antibacterial monomer MDPB (12-methacryloyloxydodecylpyridinium bromide) on inhibition of progress of root surface caries were examined by in vitro studies.1.None of the proprietary DBS demonstrated significant antibacterial effects against oral bacteria when tested by agar-disc diffusion method and MIC/MBC determination.2.Bactericidal activities of antibacterial primers containing MDPB were greater than those of any other commercial products, and the application of 4% MDPB-containing primer resulted in complete killing of bacteria in demineralized dentine.3.MDPB-containing primers were capable of penetrating deeply into the artificial and natural carious lesions.4.The progression of artificial root carious lesions, produced by either an acid-gel or a Streptococcus mutans culture technique, was completely prevented by the application of MDPB-containing DBS.5.Plaque accumulation on the surface of the demineralized dentin was inhibited when MDPB-containing DBS was applied, strong inhibition being observed by the application of MDPB-containing bonding resin.These results indicate that MDPB-containing DBS is effective in inhibiting the progress of root surface caries and of possible benefit for managing active root carious lesions.