Development of adhesive resins with the function to promote tissue regeneration by release of FGF-2

开发具有通过释放FGF-2促进组织再生功能的粘合树脂

• 批准号: 23390434
• 负责人: IMAZATO Satoshi
• 金额: $ 12.15万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390434/
• 关键词: 歯学; 修復材料; レジン; 組織再生; 接着性; FGF-2

Aiming at achievement of adhesive resins with the function to promote tissue regeneration, novel hydrogel as a carrier of protein was fabricated by copolymerization of HEMA and a cross-linking monomer. The experimental poly-HEMA-based hydrogel particle was effective for loading and long-term release of proteins. The analysis of release kinetics and in vitro cell culture studies demonstrated that FGF-2-releasing particle was successfully developed by loading FGF-2 to the experimental poly-HEMA-based hydrogel particle. In addition, 4-META/MMA-based adhesive resins were found to be possibly combined with theFGF-2-releasing hydrogel particle, and the benefits of combination of these two components were suggested.

以制备具有促进组织再生功能的黏附树脂为目标，将HEMA与交联单体共聚制备了新型的蛋白质载体水凝胶。实验制备的聚hema基水凝胶颗粒对蛋白质的加载和长期释放是有效的。释放动力学分析和体外细胞培养研究表明，通过将FGF-2装载到实验多hema基水凝胶颗粒上，成功开发了FGF-2释放颗粒。此外，发现4-META/ mma基胶粘剂树脂可能与释放fgf -2的水凝胶颗粒结合，并提出这两种成分结合的好处。

项目成果

Therapeutic polymers for dental adhesives: loading resins with bio-active components.

• DOI: 10.1016/j.dental.2013.06.003
• 发表时间: 2014-01
• 期刊: DENTAL MATERIALS
• 影响因子: 5
• 作者: Imazato, Satoshi;Ma, Sai;Chen, Ji-hua;Xu, Hockin H. K.
• 通讯作者: Xu, Hockin H. K.

Restorative materials and technique for the future: From “biomimetic” to “bio-protective & bio-promoting”

未来的修复材料和技术：从“仿生”到“生物保护和生物促进”

• 作者: 佐々木淳一;松本卓也;今里 聡;佐々木淳一，松本卓也，毛利有希子，吉本いつみ，今里 聡;Imazato S
• 通讯作者: Imazato S

Development of rechargeable CPC-loaded hydrogel particles for long-term delivery of antimicrobials

开发可充电的 CPC 负载水凝胶颗粒，用于长期提供抗菌剂

• 发表时间: 2012
• 作者: Kitagawa H;Imazato S;Hayashi M
• 通讯作者: Hayashi M

Effects of ions released from S-PRG filler on osteoblast-like cells.

S-PRG 填充剂释放的离子对成骨细胞样细胞的影响。

• 作者: Kiba W;Miki S;Imazato S.
• 通讯作者: Imazato S.

Porous zirconia/hydroxyapatite scaffolds for bone reconstruction

• DOI: 10.1016/j.dental.2012.09.001
• 发表时间: 2012-12-01
• 期刊: DENTAL MATERIALS
• 影响因子: 5
• 作者: An, Sang-Hyun;Matsumoto, Takuya;Imazato, Satoshi
• 通讯作者: Imazato, Satoshi