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Influence of incorporation of antibacterial monomer MDPB on various properties of adhesive system

抗菌单体MDPB的掺入对胶粘剂体系各项性能的影响

基本信息

批准号：
09671949
负责人：
IMAZATO Satoshi
金额：
$ 1.92万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671949/
关键词：
Dentin bonding system Antibacterial activity Restorative materials Bond strength Cytotoxicity Dentin primer Streptococcus mutans Curing 象牙質接着強さ dentime barrier test 歯髄細胞う蝕関連細菌重合性抗菌剤

项目摘要

In this study, the antibacterial effect, bond strength, and cytotoxicity of newly developed adhesive systems incorporating the antibacterial monomer MDPB (12-methacryloyloxydodecylpyridinium bromide) were investigated in vitro.Experimental primers containing 1, 2, or 5% MDPB, and adhesive with 2.5% MDPB were prepared by the addition of MDPB into the components of proprietary self-etching/priming system.The measurement of degree of conversion of the primer/adhesive complex by FTIR indicated no significant differences between any of the experimental materials and the control without MDPB.Uncured experimental primers and adhesive showed greater inhibitory effect on the growth of oral bacteria such as Streptococcus mutans compared with control, and the primer containing 5% MDPB was most effective to kill S.mutans within a short period.Additionally, MDPB-containing primer and adhesive exhibited an inhibitory effect on the growth of S.mutans on its surface even after being cured.No decrease in tensile bond strength to dentin was observed for both primers and adhesive containing MDPB.On the contrary, the primer incorporating 1 and 2% MDPB showed higher bond strength than all the others, including the control.By dentine barrier tests using human pulpal cells, incorporation of MDPB into the primer of up to 5% has been demonstrated to have no significant influence on the cytotoxicity.The results indicate that providing a dentin bonding system with antibacterial activity before and after curing could be achieved by incorporation of MDPB without influencing bond strength or cytotoxicity, suggesting that the possibility of MDPB-containing adhesive system for clinical use.

本研究对新开发的含有抗菌单体 MDPB（12-甲基丙烯酰氧基十二烷基溴化吡啶）的粘合剂体系的抗菌效果、粘合强度和细胞毒性进行了体外研究。通过将 MDPB 添加到基材中，制备了含有 1%、2% 或 5% MDPB 的实验底漆和含有 2.5% MDPB 的粘合剂。 FTIR对底漆/粘合剂复合物转化程度的测量表明，任何实验材料与不含MDPB的对照材料之间没有显着差异。与对照相比，未固化的实验底漆和粘合剂对变形链球菌等口腔细菌的生长具有更大的抑制作用，并且含有5％MDPB的底漆对杀灭最有效此外，含有 MDPB 的底漆和粘合剂即使在固化后也能抑制其表面的变形链球菌生长。含有 MDPB 的底漆和粘合剂与牙本质的拉伸粘合强度均未下降。相反，掺入 1% 和 2% MDPB 的底漆显示出比所有其他底漆（包括对照）更高的粘合强度。使用人牙髓细胞进行屏障测试，底漆中掺入高达 5% 的 MDPB 已被证明对细胞毒性没有显着影响。结果表明，通过掺入 MDPB 可以在不影响粘接强度或细胞毒性的情况下提供固化前后具有抗菌活性的牙本质粘接系统，这表明含 MDPB 的粘接系统用于临床的可能性使用。