Influence of incorporation of antibacterial monomer MDPB on various properties of adhesive system
Influence of incorporation of antibacterial monomer MDPB on various properties of adhesive system
批准号:
09671949
负责人:
IMAZATO Satoshi
金额:
$1.92万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1998
中文摘要
研究了新型抗菌单体12-甲基丙烯酰氧基十二烷基溴化吡啶(MDPB)粘接体系的体外抗菌效果、粘接强度和细胞毒性。在专有自酸蚀/底漆体系中加入1、2、5%的MDPB,制备了含1、2、5%MDPB的实验底漆和2.5%的粘接剂。FTIR测定了底漆/粘接复合体的转化率,与未固化的对照材料相比,未固化的实验底物和粘接剂对变形链球菌等口腔细菌的生长有更强的抑制作用。含5%MDPB的底漆和粘结剂在短时间内对变形链球菌的杀灭效果最好。此外,含有MDPB的底漆和粘结剂在固化后对变形链球菌的生长也有抑制作用。含有MDPB的底漆和粘接剂与牙本质的拉伸粘结强度没有下降。相反,含有1%和2%MDPB的底漆对牙本质的粘结强度高于其他所有底漆,包括对照组。通过牙本质屏障试验,结果表明,加入MDPB可以在不影响粘接强度和细胞毒性的情况下,提供固化前后具有抗菌活性的牙本质粘接系统,这表明含有MDPB的粘接系统具有临床应用的可能性。
英文摘要
In this study, the antibacterial effect, bond strength, and cytotoxicity of newly developed adhesive systems incorporating the antibacterial monomer MDPB (12-methacryloyloxydodecylpyridinium bromide) were investigated in vitro.Experimental primers containing 1, 2, or 5% MDPB, and adhesive with 2.5% MDPB were prepared by the addition of MDPB into the components of proprietary self-etching/priming system.The measurement of degree of conversion of the primer/adhesive complex by FTIR indicated no significant differences between any of the experimental materials and the control without MDPB.Uncured experimental primers and adhesive showed greater inhibitory effect on the growth of oral bacteria such as Streptococcus mutans compared with control, and the primer containing 5% MDPB was most effective to kill S.mutans within a short period.Additionally, MDPB-containing primer and adhesive exhibited an inhibitory effect on the growth of S.mutans on its surface even after being cured.No decrease in tensile bond strength to dentin was observed for both primers and adhesive containing MDPB.On the contrary, the primer incorporating 1 and 2% MDPB showed higher bond strength than all the others, including the control.By dentine barrier tests using human pulpal cells, incorporation of MDPB into the primer of up to 5% has been demonstrated to have no significant influence on the cytotoxicity.The results indicate that providing a dentin bonding system with antibacterial activity before and after curing could be achieved by incorporation of MDPB without influencing bond strength or cytotoxicity, suggesting that the possibility of MDPB-containing adhesive system for clinical use.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Imazato,S.: "Antibacterial activity of cured dental resin incorporating the antibacterial monomer MDPB and an adhesion-proncting monomer." Journal of Biomedical Matrials Research. 39(4). 511-515 (1998)
Imazato,S.:“含有抗菌单体 MDPB 和粘连单体的固化牙科树脂的抗菌活性。”
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Imazato S., Imai T., Russell R.R.B., Torii M.and Ebisu S: "Antibacterial activity of cured dental resin incorporating the antibacterial monomer MDPB and an adhesion-promoting monomer." J.Biomed.Mater.Res.39(4). 511-515 (1998)
Imazato S.、Imai T.、Russell R.R.B.、Torii M. 和 Ebisu S:“含有抗菌单体 MDPB 和粘合促进单体的固化牙科树脂的抗菌活性。”
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Imazato S., Ehara A., Torii M.and Ebisu S: "Antibacterial activity of dentine primer containing MDPB after curing" J.Dent.26(3). 267-271 (1998)
Imazato S.、Ehara A.、Torii M. 和 Ebisu S:“固化后含有 MDPB 的牙本质底漆的抗菌活性”J.Dent.26(3)。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Imazato,S.: "Antibacterial activity of cured deutal resin imcorporating the antibacterial monomer MDPB and an adhesion-promoting monomer." Journal of Biomedical Materials Research. 39(4). (1998)
Imazato,S.:“包含抗菌单体 MDPB 和粘合促进单体的固化多聚树脂的抗菌活性。”
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Historical Changes of Agricultural Plot Names and Social Groups in Japanese Villages
-
批准号:15K03011
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2015
-
负责人:IMAZATO Satoshi
-
依托单位:
Fabrication of dental pulp-like tissue using 3D cell construct
-
批准号:24659846
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2012
-
负责人:IMAZATO Satoshi
-
依托单位:
Folk agricultural plot names and physical-social conditions in Japanese vilages
-
批准号:23520952
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2011
-
负责人:IMAZATO Satoshi
-
依托单位:
Development of adhesive resins with the function to promote tissue regeneration by release of FGF-2
-
批准号:23390434
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.15万
-
财政年份:2011
-
负责人:IMAZATO Satoshi
-
依托单位:
Differences in households' and persons' folk classification knowledge of settlement space in relation to their economic class within Japanese villages
-
批准号:19720219
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.57万
-
财政年份:2007
-
负责人:IMAZATO Satoshi
-
依托单位:
The pursuit of conservative dental treatment design in a new era by diverse utilization of an antibacterial monomer
-
批准号:19209060
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$30.78万
-
财政年份:2007
-
负责人:IMAZATO Satoshi
-
依托单位:
Analysis of acid resistance of root surface and development of novel resin systems for prevention of root surface caries
-
批准号:16390545
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.51万
-
财政年份:2004
-
负责人:IMAZATO Satoshi
-
依托单位:
Development of treatment method to inhibit progress of root surface caries-Evaluation of the effects of impregnation of antibacterial resin
-
批准号:13470402
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.37万
-
财政年份:2001
-
负责人:IMAZATO Satoshi
-
依托单位:
In vivo efficacy of an adhesive system with a self-etching primer incorporating the antibacterial monomer MDPB
-
批准号:10557177
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$8.64万
-
财政年份:1998
-
负责人:IMAZATO Satoshi
-
依托单位:
海外基金