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Analysis on Pathophysiology of Functional Gastrointestinal Disorders (FGIDs) and Establishment of Comprehensive Evaluation Methods and Treatment of FGIDs

功能性胃肠病（FGIDs）的病理生理学分析及FGIDs综合评估方法和治疗方法的建立

基本信息

批准号：
15590608
负责人：
KANEKO Hiroshi
金额：
$ 2.18万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

1.Measurement of solid meal gastric and small intestinal transit time by the standard methods and establishment of respective simple procedure :From the results on gastric emptying (GE) and oro-cecal transit time (OCTT) measured by ^<13>C-octanoic acid (OA), ^<13>C-lactose ureide (LU) and radio-isotope method in normal volunteers, it was suggested that simultaneous measurement of GE and OCTT by ^<13>C-breath test be possible and accurate.2.Measurement of gastric perception threshold and gastric adaptive relaxation by the standard methods and establishment of respective simple procedure :Compared parameters obtained from standard barostat method with those by drink test, it was suggested that the simple method (eg, drink test) should estimate gastric perception and adaptive relaxation response.3.Effect of a drug on solid meal gastric and small intestinal transit time and rectal sensory threshold in patients with irritable bowel syndrome (IBS) :(1)^<13>C-breath test (OA & LU) was perform … More ed before and after drug (polycarbophil calcium) administration in IBS patients and normal volunteers, and the drug improved the accelerated GE in IBS.(2)The drug improved the symptoms and quality of life in diarrhea-predominant IBS patients, and in some cases rectal sensory threshold and compliance were also increased.4.Measurement of brain blood flow (BBF) under rectal balloon distension in patients with functional gastrointestinal disorders and the effect of the stressor(s) on BBF (brain-gut interaction)BBF was measured in conditions with rectal distension (mechanical stressor) and/or mental arithmetic (psychological stressor) by positron emission tomography in diarrhea-predominant IBS patients and normal volunteers. Differences in pain response to the stressor(s) and the region of increased BBF between IBS and volunteers are demonstated.5.Establishment of psychosomatic diagnosis and treatment strategy for intractable functional dyspepsia (FD) :Half of intractable FD patients were diagnosed as somatoform disorders who are resistant to ordinary drug therapy. A novel treatment strategy for those patients was proposed. Validation study should be essential. Less

1.固体餐胃、小肠通过时间的标准方法测定及简易程序的建立：通过对正常人胃排空（GE）、口盲肠通过时间（OCTT）的测定<13><13>，表明用~（13）C-呼气试验同时测定GE和OCTT<13>是可行和准确的。2.胃感觉阈值和胃适应性舒张的标准方法测定及简易程序的建立：通过对标准恒压法和饮料试验所得参数的比较，认为简易恒压法3.药物对肠易激综合征（IBS）患者固体餐胃、小肠通过时间及直肠感觉阈值的影响：（1）进行<13>C-呼吸试验（OA & LU） ...更多信息对IBS患者和正常人服用聚卡波非钙前后的艾德进行了研究，发现聚卡波非钙能改善IBS患者的加速GE。（2）该药能改善以肠易激综合征为主的IBS患者的症状和生活质量，4.功能性胃肠病患者直肠球囊扩张时脑血流量的测定及应激源对脑血流量的影响在直肠扩张（机械应激源）和/或心算（心理应激源）的条件下，通过正电子发射断层扫描在肠易激综合征患者和正常志愿者中测量BBF。5.难治性功能性消化不良（FD）心身诊断和治疗策略的建立：难治性FD患者中有一半被诊断为躯体形式障碍，对常规药物治疗无效。为这些患者提出了一种新的治疗策略。验证研究必不可少。少