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Analysis on Pathophysiology of Functional Gastrointestinal Disorders (FGIDs) and Establishment of Comprehensive Evaluation Methods and Treatment of FGIDs

功能性胃肠病（FGIDs）的病理生理学分析及FGIDs综合评估方法和治疗方法的建立

基本信息

批准号：
15590608
负责人：
KANEKO Hiroshi
金额：
$ 2.18万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

1.Measurement of solid meal gastric and small intestinal transit time by the standard methods and establishment of respective simple procedure :From the results on gastric emptying (GE) and oro-cecal transit time (OCTT) measured by ^<13>C-octanoic acid (OA), ^<13>C-lactose ureide (LU) and radio-isotope method in normal volunteers, it was suggested that simultaneous measurement of GE and OCTT by ^<13>C-breath test be possible and accurate.2.Measurement of gastric perception threshold and gastric adaptive relaxation by the standard methods and establishment of respective simple procedure :Compared parameters obtained from standard barostat method with those by drink test, it was suggested that the simple method (eg, drink test) should estimate gastric perception and adaptive relaxation response.3.Effect of a drug on solid meal gastric and small intestinal transit time and rectal sensory threshold in patients with irritable bowel syndrome (IBS) :(1)^<13>C-breath test (OA & LU) was perform … More ed before and after drug (polycarbophil calcium) administration in IBS patients and normal volunteers, and the drug improved the accelerated GE in IBS.(2)The drug improved the symptoms and quality of life in diarrhea-predominant IBS patients, and in some cases rectal sensory threshold and compliance were also increased.4.Measurement of brain blood flow (BBF) under rectal balloon distension in patients with functional gastrointestinal disorders and the effect of the stressor(s) on BBF (brain-gut interaction)BBF was measured in conditions with rectal distension (mechanical stressor) and/or mental arithmetic (psychological stressor) by positron emission tomography in diarrhea-predominant IBS patients and normal volunteers. Differences in pain response to the stressor(s) and the region of increased BBF between IBS and volunteers are demonstated.5.Establishment of psychosomatic diagnosis and treatment strategy for intractable functional dyspepsia (FD) :Half of intractable FD patients were diagnosed as somatoform disorders who are resistant to ordinary drug therapy. A novel treatment strategy for those patients was proposed. Validation study should be essential. Less

1.通过标准方法测量固体食物胃和小肠通过时间并建立相应的简单程序：根据^ 13 C-辛酸（OA）、^ 13 C-乳糖脲（LU）和放射性同位素法测量正常志愿者的胃排空（GE）和口盲肠通过时间（OCTT）结果，建议同时进行通过^<13>C-呼吸测试测量GE和OCTT是可能且准确的。2.通过标准方法测量胃知觉阈值和胃适应性松弛并建立各自的简单程序：将标准恒压法获得的参数与通过饮酒测试获得的参数进行比较，建议简单方法（例如，饮酒测试）应该估计胃知觉和适应性松弛反应。3. 药物对肠易激综合征（IBS）患者固体食物胃和小肠通过时间和直肠感觉阈值的影响：（1）^<13>在IBS患者和正常志愿者服用药物（聚卡波非钙）之前和之后进行C呼吸测试（OA＆LU），该药物改善了IBS的加速GE。（2）该药物改善了症状和生活质量腹泻为主的IBS患者，在某些情况下直肠感觉阈值和顺应性也增加。4.功能性胃肠道疾病患者直肠球囊扩张下脑血流量（BBF）的测量以及应激源对BBF的影响（脑肠相互作用）在直肠扩张（机械应激源）和/或心算条件下测量BBF （心理压力源）通过正电子发射断层扫描对腹泻为主的 IBS 患者和正常志愿者进行研究。展示了IBS与志愿者之间对应激源的疼痛反应以及BBF增加的区域的差异。5.顽固性功能性消化不良（FD）心身诊断和治疗策略的建立：一半顽固性FD患者被诊断为对普通药物治疗有抵抗力的躯体形式障碍。为这些患者提出了一种新的治疗策略。验证研究应该是必要的。较少的