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Analysis on Pathophysiology of Functional Gastrointestinal Disorders (FGIDs) and Establishment of Comprehensive Evaluation Methods and Treatment of FGIDs

功能性胃肠病（FGIDs）的病理生理学分析及FGIDs综合评估方法和治疗方法的建立

基本信息

批准号：
15590608
负责人：
KANEKO Hiroshi
金额：
$ 2.18万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

1.Measurement of solid meal gastric and small intestinal transit time by the standard methods and establishment of respective simple procedure :From the results on gastric emptying (GE) and oro-cecal transit time (OCTT) measured by ^<13>C-octanoic acid (OA), ^<13>C-lactose ureide (LU) and radio-isotope method in normal volunteers, it was suggested that simultaneous measurement of GE and OCTT by ^<13>C-breath test be possible and accurate.2.Measurement of gastric perception threshold and gastric adaptive relaxation by the standard methods and establishment of respective simple procedure :Compared parameters obtained from standard barostat method with those by drink test, it was suggested that the simple method (eg, drink test) should estimate gastric perception and adaptive relaxation response.3.Effect of a drug on solid meal gastric and small intestinal transit time and rectal sensory threshold in patients with irritable bowel syndrome (IBS) :(1)^<13>C-breath test (OA & LU) was perform … More ed before and after drug (polycarbophil calcium) administration in IBS patients and normal volunteers, and the drug improved the accelerated GE in IBS.(2)The drug improved the symptoms and quality of life in diarrhea-predominant IBS patients, and in some cases rectal sensory threshold and compliance were also increased.4.Measurement of brain blood flow (BBF) under rectal balloon distension in patients with functional gastrointestinal disorders and the effect of the stressor(s) on BBF (brain-gut interaction)BBF was measured in conditions with rectal distension (mechanical stressor) and/or mental arithmetic (psychological stressor) by positron emission tomography in diarrhea-predominant IBS patients and normal volunteers. Differences in pain response to the stressor(s) and the region of increased BBF between IBS and volunteers are demonstated.5.Establishment of psychosomatic diagnosis and treatment strategy for intractable functional dyspepsia (FD) :Half of intractable FD patients were diagnosed as somatoform disorders who are resistant to ordinary drug therapy. A novel treatment strategy for those patients was proposed. Validation study should be essential. Less

1.用标准方法测定固体餐胃和小肠运输时间，并建立各自的简单程序：从正常志愿者用^<13> c -辛酸（OA）、^<13> c -乳糖脲（LU）和放射性同位素法测定胃排空（GE）和口盲肠运输时间（OCTT）的结果，提示用^<13> c -呼气试验同时测定GE和OCTT是可能的和准确的。用标准方法测量胃感觉阈值和胃适应性松弛，并建立相应的简单程序：将标准恒压法与饮料试验所得参数进行比较，建议用简单方法（如饮料试验）来估计胃感觉和适应性松弛反应。一种药物对肠易激综合征（IBS）患者固体膳食胃小肠传递时间和直肠感觉阈值的影响：(1)对IBS患者和正常志愿者进行<13>的c -呼气试验（OA & LU），在给药前后进行了更多的测试，该药物改善了IBS患者加速的GE。(2)该药改善了以腹泻为主的IBS患者的症状和生活质量，部分患者的直肠感觉阈值和顺应性也有所提高。采用正电子发射断层扫描技术，对腹泻为主的IBS患者和正常志愿者进行直肠膨胀（机械压力源）和/或心算（心理压力源）条件下的脑血流量（BBF）及应激源对脑肠相互作用（BBF）的影响进行测量。证实了IBS和志愿者对应激源的疼痛反应和BBF增加区域的差异。难治性功能性消化不良（FD）心身诊疗策略的建立：半数难治性功能性消化不良患者诊断为躯体形式障碍，对普通药物治疗有耐药性。提出了一种新的治疗策略。验证研究应该是必不可少的。少