Development and evaluation of limitation including error and reproducibility on assessment method of cerebral function using MRI

MRI脑功能评估方法误差及重复性局限性的开发与评价

• 批准号: 15591280
• 负责人: HARADA Masafumi
• 金额: $ 2.24万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591280/
• 关键词: FAIR; Proton MRS; 3T MRI; Perfusion; Metabolism; Glutamate; GABA; LCModel; LCModeol; proton MRS; fMRI; perfusion; LCModel; ICC; ICA

The purpose of this study is to evaluate the possibility and problem including error and reproducibility on the perfusion MRI and proton MR spectroscopy (proton MRS).On perfusion MRI, flow sensitive alternating inversion recovery (FAIR) sequence was made and installed into our clinical MRI instrument. The different inversion times on FAIR were selected and compared with the cerebral blood perfusion using SPECT. The signal ratio (SR16/8) of two images with different TIs (1600ms and 800ms) was calculated and the cerebral blood flow reserve (CFR) was evaluated by the increase in the ratio of cerebral perfusion after administration of acetazolamide in the SPECT study. A reversed linear correlation (r=0.75) was found between SR and CFR, indicating that differences of FAIR images with changes of TI will be affected by cerebral flow reserve.On proton MRS, the accuracy after curve-fitting of frequency domain data was increased by high magnetic field instrument at 3 Tesla, and the error was limited under 10%. The peak of glutamate and glutamine complex was also evaluated and the concentration of glutamate alone could be quantified with LCModel analysis on 3T MRS data. The value of SD of Glx by LCModel was under 15% and that of glutamate was under 25%.Furthermore, the sequence of MEGA-PRESS was made into 3 Tesla MRI with frequency selective 180° pulses to detect peak of gamma amino-butyric acid (GABA). By this sequence, GABA was separated from other major metabolites at 3.01 ppm and the concentration of GABA was quantified with LCModel. The SD value of GABA was under 25% and its quantified value was agreed with the literature value.The results indicates the new parameter of cerebral perfusion and the improvement of accuracy and reproducibility on proton MRS by high magnetic field at 3 Tesla.

本研究的目的是评估灌注MRI和质子磁共振波谱（质子MRS）的可能性和问题，包括误差和再现性。在灌注MRI上，制作了流敏交替反转恢复（FAIR）序列并将其安装到我们的临床MRI仪器中。选择FAIR上的不同反转时间并使用SPECT与脑血流灌注进行比较。计算不同TI（1600ms和800ms）的两幅图像的信号比（SR16/8），并通过SPECT研究中给予乙酰唑胺后脑灌注比率的增加来评估脑血流储备（CFR）。 SR和CFR之间存在反向线性相关性（r=0.75），表明FAIR图像随TI变化的差异会受到脑血流储备的影响。在质子MRS上，通过3特斯拉强磁场仪器对频域数据进行曲线拟合后的精度提高，误差限制在10%以下。还评估了谷氨酸和谷氨酰胺复合物的峰，并且可以通过 3T MRS 数据的 LC 模型分析单独量化谷氨酸的浓度。 LCModel的Glx的SD值在15%以下，谷氨酸的SD值在25%以下。此外，将MEGA-PRESS的序列制成3 Tesla MRI，频率选择性180°脉冲，检测γ氨基丁酸（GABA）的峰。通过该序列，GABA 以 3.01 ppm 与其他主要代谢物分离，并使用 LCModel 定量 GABA 的浓度。 GABA的SD值在25%以下，其量化值与文献值一致。结果表明新的脑灌注参数以及3特斯拉高磁场质子MRS的准确性和再现性的提高。

项目成果

雑音から脳活動を拾い上げる

从噪音中获取大脑活动

• 发表时间: 2004
• 期刊: 電子情報通信学会誌 87巻3号
• 作者: Masaaki Uno;et al.;原田雅史;原田雅史
• 通讯作者: 原田雅史

H.kubo, M.Harada, et al.: "Reproducibility of metabolite concentration evaluated by intraclass correlation coefficient using clinical MR apparatus"Journal Computer Associated Tomography. 27・3. 449-453 (2003)

H.kubo、M.Harada 等：“使用临床 MR 设备通过组内相关系数评估代谢物浓度的再现性”Journal Computer Associated Tomography 27・3 (2003)。

脳虚血の画像診断

脑缺血的影像诊断

• 发表时间: 2004
• 期刊: 脳神経外科ジャーナル 13巻
• 作者: Masaaki Uno;et al.;原田雅史
• 通讯作者: 原田雅史

原田雅史: "雑音から脳活動を拾い上げる-ICAの脳機能MRIへの応用-"電子情報通信学会誌. 87・3. 201-206 (2004)

原田正史：“从噪声中拾取大脑活动 - ICA 在功能性大脑 MRI 中的应用”，电子信息通信工程师学会杂志 87・3（2004 年）。

Elevation of plasma oxidized LDL in acute stroke patients is associated with predictive of infarct enlargement.

急性中风患者血浆氧化低密度脂蛋白的升高与梗塞扩大的预测相关。

• 发表时间: 2005
• 期刊: Neurological Research 27
• 作者: Masaaki Uno;Masafumi Harada;Osamu Takimoto;Keiko T.Kitazato;Atsuhiko Suzue;Kazuhide Yoneda;Naomi Morita;Hiroyuki Itabe;Shinji Nagahiro
• 通讯作者: Shinji Nagahiro