权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Homeostatic maintenance of mineralization in dental hard tissue by saliva

唾液对牙齿硬组织矿化的稳态维持

基本信息

批准号：
15591949
负责人：
MIAKE Yasuo
金额：
$ 1.79万
依托单位：
Tokyo Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591949/
关键词：
Remineralization Saliva Caries Dentin Tooth root う蝕エナメル質初期齲蝕

项目摘要

This research was to clarify crystallographically the role of saliva or a remineralizing solution in demineralized dentin and to determine the effectiveness of a food additive to promote acid resistance in root dentin exposed during periodontal-disease therapy.We used completely impacted human third molars extracted for therapeutic reasons from patients aged from 20 to 40 yr. Informed consent was obtained for the experimental use of the extracted teeth. The Ethics Committee of Tokyo Dental College approved both the acquisition and the experimental use of the materials.1. Remineralization of demineralized dentinRemineralization by means of saliva would seem to be excellent because a remineralized layer forms on the surface and remineralization throughout improves. But HR-TEM shows that dense crystal deposition at the surface layer may actually inhibit mineral permeation to lower levels. The addition of F-Ca-CO to saliva, however, causes mineralization, not at the surface, but in deeper … More layers and therefore is thought to promote overall mineralization in the long term. The degree of deep-layer mineralization induced by a remineralizing solution is thought to be slight because the solution is low in Ca and P. It was believed that the addition of F-Ca-CO would cause high-degree remineralization by increasing Ca and adding F. The addition of F alone caused strong remineralization at the surface layer, whereas the addition of F-Ca-CO caused remineralization from the inner regions of the demineralized layer. This phenomenon led to the idea that something other than F plays a big role.2. Tests on Dentinal Demineralization ResistanceImmersion in a remineralizing solution increased dentinal resistance to demineralization, and the addition of F-Ca-CO increased it still further. Because it causes greater mineral deposition owing to the actions of Ca and F, the additive improves crystal formation. Consequently, the addition of F-Ca-CO is believed to strengthen resistance to demineralization. Less

本研究旨在从结晶学角度阐明唾液或再矿化溶液在脱矿牙本质中的作用，并确定一种食品添加剂在牙周病治疗期间提高牙根牙本质耐酸性的有效性。我们使用年龄在20 - 40岁的患者因治疗原因拔出的完全阻生的人类第三磨牙。拔牙的实验使用已获得知情同意。东京牙科学院伦理委员会批准了材料的获取和实验使用。脱矿牙本质的再矿化通过唾液的再矿化似乎是很好的，因为在表面形成了一层再矿化层，并且整个再矿化得到改善。但hrtem显示，表层致密的晶体沉积实际上可能会抑制矿物向较低水平的渗透。然而，在唾液中添加F-Ca-CO会导致矿化，但不是在表面，而是在更深的层次上，因此被认为从长远来看会促进整体矿化。再矿化溶液中Ca和p的含量较低，导致深层矿化程度较轻，认为加入F-Ca- co可以通过增加Ca和F来引起高度的再矿化。单独加入F会在表层引起强烈的再矿化，而加入F-Ca- co则会引起脱矿层内部区域的再矿化。这一现象导致了一种想法，即除了F之外的其他东西起了很大的作用。牙本质脱矿阻力试验：浸在再矿化溶液中会增加牙本质的脱矿阻力，而加入F-Ca-CO则会进一步提高牙本质的脱矿阻力。由于Ca和F的作用，它引起更大的矿物沉积，因此添加剂改善了晶体的形成。因此，F-Ca-CO的加入被认为增强了对脱矿的抵抗力。少