Immunological background in paraneoplastic neurological syndrome and its therapeutic approach

副肿瘤性神经综合征的免疫背景及其治疗方法

基本信息

  • 批准号:
    17590868
  • 负责人:
  • 金额:
    $ 2.24万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2006
  • 项目状态:
    已结题

项目摘要

Paraneoplastic neurological syndrome (PNS) is categorized in autoimmune neurological disease ; in that, cancer immunity and autoimmune mechanisms to neuronal tissue are both elicited in PNS. Because the tumor is often very small to be detected with conventional screening system, anti-tumor immunity might be accelerated at least in early stage of PNS. Furthermore, PNS develops in a small population of patients who have similar tumor pathology, suggesting that PNS patients might have special immunological backgrounds to tune up immunity on tumor and nervous tissue.To inspect this hypothesis, we analyzed prevalence of lymphocyte subpopulation and regulatory T cell (Treg) mRNA expression of functional molecules such as FOXP3, TGF-pi, CTLA-4 and GITR in Treg-rich fraction from peripheral blood of PNS patients.As the results, the expression of FOXP3 and CTLA-4 mRNA were diminished in PNS, group compared to cancer patients without neurological symptom, suggesting PNS develops in those cancer patients having dysfunction in Treg system. These results have brought a new insight in understanding the pathomechanisms of PNS and in constructing a treatment strategy for underlying cancer.
副肿瘤性神经综合征(PNS)属于自身免疫性神经系统疾病,在PNS中,肿瘤免疫和对神经组织的自身免疫机制都被激发。由于肿瘤通常很小,无法用常规筛查系统检测到,因此至少在PNS的早期阶段,抗肿瘤免疫可能会被加速。此外,PNS发生在具有相似肿瘤病理学的少数患者中,这表明PNS患者可能具有特殊的免疫学背景,以调节肿瘤和神经组织的免疫。为了验证这一假设,我们分析了淋巴细胞亚群和调节性T细胞(Treg)功能分子如FOXP 3,TGF-β 1,结果表明,与无神经系统症状的癌症患者相比,PNS组FOXP 3和CTLA-4 mRNA的表达减少,提示PNS发生于Treg系统功能障碍的癌症患者。这些结果为理解PNS的病理机制和构建潜在癌症的治疗策略带来了新的见解。

项目成果

期刊论文数量(93)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
整形外科学大系 22巻 越智隆弘編(製本中)
《骨科》第 22 卷,大智贵宏主编(已装订)
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Arakawa T;Niikurat T;Tajima H;Kita Y;Maruyama M;Arimura K and Hashiguchi T;田中惠子
  • 通讯作者:
    田中惠子
Reevaluation of the usefulness of creatinine % in urine
重新评估%20of%20%20有用性%20of%20肌酐%20%%20in%20尿液
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shimohata T;Umeda M;Tanaka K;Nishizawa M.
  • 通讯作者:
    Nishizawa M.
A case of HIV encephalopathy showing Lower body parkinsonism during HAART.
一例 HIV 脑病在 HAART 期间显示下半身帕金森病。
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shimohata T;Takado Y;Terashima K;Tsukada H;Gejyo F;Tanaka K;Nishizawa M.
  • 通讯作者:
    Nishizawa M.
Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma
嗅神经上皮瘤的副肿瘤性小脑变性
イヌ回虫性脊髄炎の1例
犬蛔虫性脊髓炎一例
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Hanajima R;Dostrovsky JO;Lozano AM;Chen R;Matsui M;石原智彦ら
  • 通讯作者:
    石原智彦ら
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TANAKA Keiko其他文献

TANAKA Keiko的其他文献

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{{ truncateString('TANAKA Keiko', 18)}}的其他基金

Philological Study on Takimono Culture Towards Comprehensive Recognition and Revitalization of Takimono Culture
泷物文化的语言学研究 全面认识泷物文化并振兴泷物文化
  • 批准号:
    18K00340
  • 财政年份:
    2018
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Elucidation of mechanism of renal fibrosis and prognosis in chronic kidney disease by analyzing factors originated from tubular epithelium
通过分析肾小管上皮来源的因素阐明慢性肾脏病肾纤维化的机制和预后
  • 批准号:
    18K16002
  • 财政年份:
    2018
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Measuring Intimacy of Intergenerational Relationship by Intergenerational-Ambivalence Approach
用代际矛盾心理法衡量代际关系的亲密程度
  • 批准号:
    17K04188
  • 财政年份:
    2017
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Pathomechanisms of anti-NMDA receptor encephalitis
抗NMDA受体脑炎的发病机制
  • 批准号:
    23500455
  • 财政年份:
    2011
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Hirata Goyo and Japanese doll art movement: a study of documents owned by Hirata Goyo
平田吾代与日本人偶艺术运动:平田吾代拥有的文献研究
  • 批准号:
    23720074
  • 财政年份:
    2011
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
A cohort study for identifying risk factors of dental caries in children
识别儿童龋齿危险因素的队列研究
  • 批准号:
    22592355
  • 财政年份:
    2010
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Epidemiological study on the association between environmental and heritable factors and periodontal disease
环境及遗传因素与牙周病关系的流行病学研究
  • 批准号:
    20791654
  • 财政年份:
    2008
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Establishment of diagnostic procedures for paraneoplastic neurological syndrome with specific-antineuronal antibodies, and the study for the pathomechanisms of paraneoplastic neurological syndrome
特异性抗神经元抗体诊断副肿瘤性神经综合征的方法建立及副肿瘤性神经综合征发病机制的研究
  • 批准号:
    14570583
  • 财政年份:
    2002
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Pathomechanisms of paraneoplastic neurological syndrome-neuronal damege mediated by cytotoxic T cells
副肿瘤性神经综合征-细胞毒性T细胞介导的神经元损伤的发病机制
  • 批准号:
    11670614
  • 财政年份:
    1999
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Developing a Method for the Prospective and Quantitative Evaluation of Labor Pains: Toward the safer assistance of women during labor
开发一种对分娩疼痛进行前瞻性和定量评估的方法:为妇女在分娩过程中提供更安全的帮助
  • 批准号:
    11672373
  • 财政年份:
    1999
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

Research for immunological background in patients with childhood-onset myasthenia gravis (preliminary step toward novel immunosuppressive therapy)
儿童期重症肌无力患者的免疫学背景研究(新型免疫抑制治疗的初步步骤)
  • 批准号:
    18K15703
  • 财政年份:
    2018
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Study in the prevalence of cryptococcal meningitis and its mycological and immunological background in China
我国隐球菌性脑膜炎流行情况及其真菌学和免疫学背景研究
  • 批准号:
    16H05841
  • 财政年份:
    2016
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Establishment of tretments for patients with atopic dermatitis based on the immunological background
基于免疫学背景建立特应性皮炎患者的治疗方法
  • 批准号:
    14570795
  • 财政年份:
    2002
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Studies on the genetical and immunological background of the genesis of preeclampsia by analyzing HLA-class II genotype.
通过分析HLA-II类基因型研究子痫前期发生的遗传和免疫学背景。
  • 批准号:
    10671524
  • 财政年份:
    1998
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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