Pathomechanisms of anti-NMDA receptor encephalitis

抗NMDA受体脑炎的发病机制

• 批准号: 23500455
• 负责人: TANAKA Keiko
• 金额: $ 3.41万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500455/
• 关键词: グルタミン酸受容体; NMDA受容体; 辺縁系脳炎; 長期増強誘導; 海馬細胞; 記銘力障害; 急性脳炎; long term potentiation; 病態モデル

The roles of anti-N-methyl-D-aspartate receptor (NMDAR) antibodies from patients with NMDAR encephalitis on their neurological symptom were examined. The major symptom of NMDAR encephalitis is known as amnesia together with convulsions and other psychiatric symptoms. To reproduce these symptoms, we examined behavior of mice exposed chronically to the cerebrospinal fluid (CSF) from patients and found that mice injected with the CSF exhibited learning impairment. However, their brain tissues did not exhibit inflammatory cell infiltration, neuronal loss, or glial proliferation, and there was no increase in inflammatory cytokines. Thus, for the first time, we showed that the CSF from NMDAR encephalitis patients disturbed the memory function directly in mice. These effects were considered to be functional and without neuronal tissue destruction, which is compatible with the favorable outcome of this disease.

本文探讨了N-甲基-D-天冬氨酸受体（NMDAR）脑炎患者血清中抗NMDAR抗体在神经系统症状中的作用。NMDAR脑炎的主要症状被称为健忘症，伴有抽搐和其他精神症状。为了重现这些症状，我们检查了长期暴露于患者脑脊液（CSF）的小鼠的行为，发现注射CSF的小鼠表现出学习障碍。然而，他们的脑组织没有表现出炎性细胞浸润，神经元丢失，或神经胶质增生，也没有增加炎性细胞因子。因此，我们第一次证明了来自NMDAR脑炎患者的CSF直接干扰了小鼠的记忆功能。这些效应被认为是功能性的，没有神经元组织破坏，这与该疾病的有利结局一致。

项目成果

A Young Man with Anti-NMDAR Encephalitis following Guillain-Barré Syndrome.

• DOI: 10.1159/000323751
• 发表时间: 2011-01-11
• 期刊: Case reports in neurology
• 影响因子: 0.7
• 作者: Tojo K;Nitta K;Ishii W;Sekijima Y;Morita H;Takahashi Y;Tanaka K;Ikeda S
• 通讯作者: Ikeda S

日本人clinically isolated syndrome患者の脳MRI所見

日本临床孤立综合征患者的脑部MRI表现

• DOI: 10.5692/clinicalneurol.52.725
• 发表时间: 2012
• 期刊: Rinshō shinkeigaku Clinical neurology
• 作者: Masami Tanaka;R. Motoyama;M. Tahara;Keiko Tanaka
• 通讯作者: Keiko Tanaka

傍腫瘍性神経症候群

副肿瘤性神经综合征

• 发表时间: 2013
• 期刊: 成人病と生活習慣病
• 作者: 原宏士朗;藤枝智美;入江智彦;三輪秀樹;岡淳一郎;白尾智明;花尻(木倉)瑠理;合田幸広;栗原正明;関野祐子;斎藤祐見子;田中惠子
• 通讯作者: 田中惠子

抗NMDA受容体抗体が陽性であった脳炎，統合失調症，精神症状を伴うナルコレプシーの症例

抗NMDA受体抗体阳性的脑炎、精神分裂症、发作性睡病伴精神病症状病例

• 发表时间: 2012
• 期刊: Jpn I Gen Hosp Psychiatry
• 作者: 高堂裕平;ら;筒井 幸，ら
• 通讯作者: 筒井 幸，ら

Assembly defect due Q:1 to a PSMB8 mutation ; 2 reduces proteasome activity and causes the autoinflammatory disorder, Nakajo-Nishimura syndrome

由于 PSMB8 突变导致 Q:1 组装缺陷；

• 发表时间: 2011
• 期刊: PNAS
• 作者: K Arima;et al.
• 通讯作者: et al.