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Establishment of diagnostic procedures for paraneoplastic neurological syndrome with specific-antineuronal antibodies, and the study for the pathomechanisms of paraneoplastic neurological syndrome

Establishment of diagnostic procedures for paraneoplastic neurological syndrome with specific-antineuronal antibodies, and the study for the pathomechanisms of paraneoplastic neurological syndrome
特异性抗神经元抗体诊断副肿瘤性神经综合征的方法建立及副肿瘤性神经综合征发病机制的研究
批准号:
14570583
负责人:
TANAKA Keiko
金额:
$2.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2003

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中文摘要
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英文摘要
For the specific and quick diagnosis of paraneoplastic neurological syndromes, we produced several recombinant antigen proteins (Yo/Hu/Ri/CRMP-5,/Ma-2) and used as antigens for western blot or ELISA. We analysed the frequency of these antibody positivity among 1500 samples which sent us for the diagnosis of paraneoplastic neurological syndromes. We found anti-Yo antibody in 1.5% of these sera and anti-Hu antibody in 2.3%.For those with specific antibody-positive patients, we analysed the HLA type under the informed consent, and found the similar amimo acid motifs in their class I molecules, which would be used as the targets for cytotoxic T cell assay.
期刊论文(162)
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会议论文
Arai A: "A novel mutation in the GNE gene and a linkage disequilibrium in Japanese pedigrees with DMRV (Nonaka myopathy)"Ann Neurlo. 52. 516-519 (2002)
Arai A:“GNE 基因的新突变和日本 DMRV(野中肌病)谱系中的连锁不平衡”Ann Neurlo。
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Oguma T: "Paraneoplastic striatal encephalitis"Neurology. 57. 2326-2326 (2002)
Oguma T:“副肿瘤性纹状体脑炎”神经病学。
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Takadou Y, Igarashi S, Akaiwa Y, Terashima K, Tanaka K, Tsuji S.: "Pathological laugh in patient with pontine base lesion in multiple sclerosis"Clin Neurbl. 42. 519-522 (2002)
Takadou Y、Igarashi S、Akaiwa Y、Terashima K、Tanaka K、Tsuji S.:“多发性硬化症脑桥基部病变患者的病理性笑”Clin Neurbl。
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Hirahara K, Takadou Y, Shimohata M, Igarashi S, Tanaka K, Tsuji S: "Successful treatment with intravenous immunoglobulin therapy in a patient with diabetic amyotrophy"Neurol Therapeutics. 20. 81-85 (2003)
Hirahara K、Takadou Y、Shimohata M、Igarashi S、Tanaka K、Tsuji S:“静脉注射免疫球蛋白治疗糖尿病肌萎缩症患者的成功治疗”Neurol Therapeutics。
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72
    Philological Study on Takimono Culture Towards Comprehensive Recognition and Revitalization of Takimono Culture
    Elucidation of mechanism of renal fibrosis and prognosis in chronic kidney disease by analyzing factors originated from tubular epithelium
    • 批准号:
      18K16002
    • 项目类别:
      Grant-in-Aid for Early-Career Scientists
    • 资助金额:
      $2.66万
    • 财政年份:
      2018
    • 负责人:
      TANAKA Keiko
    • 依托单位:
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    • 批准号:
      23500455
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2011
    • 负责人:
      TANAKA Keiko
    • 依托单位:
    海外基金