Establishment of diagnostic procedures for paraneoplastic neurological syndrome with specific-antineuronal antibodies, and the study for the pathomechanisms of paraneoplastic neurological syndrome
Establishment of diagnostic procedures for paraneoplastic neurological syndrome with specific-antineuronal antibodies, and the study for the pathomechanisms of paraneoplastic neurological syndrome
批准号:
14570583
负责人:
TANAKA Keiko
金额:
$2.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2003
中文摘要
点击翻译按钮获取中文摘要
英文摘要
For the specific and quick diagnosis of paraneoplastic neurological syndromes, we produced several recombinant antigen proteins (Yo/Hu/Ri/CRMP-5,/Ma-2) and used as antigens for western blot or ELISA. We analysed the frequency of these antibody positivity among 1500 samples which sent us for the diagnosis of paraneoplastic neurological syndromes. We found anti-Yo antibody in 1.5% of these sera and anti-Hu antibody in 2.3%.For those with specific antibody-positive patients, we analysed the HLA type under the informed consent, and found the similar amimo acid motifs in their class I molecules, which would be used as the targets for cytotoxic T cell assay.
期刊论文(162)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Arai A: "A novel mutation in the GNE gene and a linkage disequilibrium in Japanese pedigrees with DMRV (Nonaka myopathy)"Ann Neurlo. 52. 516-519 (2002)
Arai A:“GNE 基因的新突变和日本 DMRV(野中肌病)谱系中的连锁不平衡”Ann Neurlo。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Oguma T: "Paraneoplastic striatal encephalitis"Neurology. 57. 2326-2326 (2002)
Oguma T:“副肿瘤性纹状体脑炎”神经病学。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Takadou Y, Igarashi S, Akaiwa Y, Terashima K, Tanaka K, Tsuji S.: "Pathological laugh in patient with pontine base lesion in multiple sclerosis"Clin Neurbl. 42. 519-522 (2002)
Takadou Y、Igarashi S、Akaiwa Y、Terashima K、Tanaka K、Tsuji S.:“多发性硬化症脑桥基部病变患者的病理性笑”Clin Neurbl。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Hirahara K, Takadou Y, Shimohata M, Igarashi S, Tanaka K, Tsuji S: "Successful treatment with intravenous immunoglobulin therapy in a patient with diabetic amyotrophy"Neurol Therapeutics. 20. 81-85 (2003)
Hirahara K、Takadou Y、Shimohata M、Igarashi S、Tanaka K、Tsuji S:“静脉注射免疫球蛋白治疗糖尿病肌萎缩症患者的成功治疗”Neurol Therapeutics。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
田中 正美: "抗Yo抗体と傍腫瘍性小脳変性症"医学のあゆみ. 201. 185-187 (2002)
Masami Tanaka:“抗 Yo 抗体和副肿瘤性小脑变性”医学史 201. 185-187 (2002)。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 72 条
Philological Study on Takimono Culture Towards Comprehensive Recognition and Revitalization of Takimono Culture
-
批准号:18K00340
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.33万
-
财政年份:2018
-
负责人:TANAKA Keiko
-
依托单位:
Elucidation of mechanism of renal fibrosis and prognosis in chronic kidney disease by analyzing factors originated from tubular epithelium
-
批准号:18K16002
-
项目类别:Grant-in-Aid for Early-Career Scientists
-
资助金额:$2.66万
-
财政年份:2018
-
负责人:TANAKA Keiko
-
依托单位:
Measuring Intimacy of Intergenerational Relationship by Intergenerational-Ambivalence Approach
-
批准号:17K04188
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
-
财政年份:2017
-
负责人:TANAKA Keiko
-
依托单位:
Pathomechanisms of anti-NMDA receptor encephalitis
-
批准号:23500455
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2011
-
负责人:TANAKA Keiko
-
依托单位:
Hirata Goyo and Japanese doll art movement: a study of documents owned by Hirata Goyo
-
批准号:23720074
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.75万
-
财政年份:2011
-
负责人:TANAKA Keiko
-
依托单位:
A cohort study for identifying risk factors of dental caries in children
-
批准号:22592355
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2010
-
负责人:TANAKA Keiko
-
依托单位:
Epidemiological study on the association between environmental and heritable factors and periodontal disease
-
批准号:20791654
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2008
-
负责人:TANAKA Keiko
-
依托单位:
Immunological background in paraneoplastic neurological syndrome and its therapeutic approach
-
批准号:17590868
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2005
-
负责人:TANAKA Keiko
-
依托单位:
Pathomechanisms of paraneoplastic neurological syndrome-neuronal damege mediated by cytotoxic T cells
-
批准号:11670614
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:1999
-
负责人:TANAKA Keiko
-
依托单位:
Developing a Method for the Prospective and Quantitative Evaluation of Labor Pains: Toward the safer assistance of women during labor
-
批准号:11672373
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:1999
-
负责人:TANAKA Keiko
-
依托单位:
Cytotoxic T cell mediated paraneoplastic neurological syndromes
-
批准号:08670699
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1996
-
负责人:TANAKA Keiko
-
依托单位:
Immunological Study for the Pathogenesis of Adrenoleukodystrophy
-
批准号:03670413
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1991
-
负责人:TANAKA Keiko
-
依托单位:
海外基金