Large-scale knowledge information processing in genome analysis

基因组分析中的大规模知识信息处理

• 批准号: 04261102
• 负责人: KANEHISA Minoru
• 金额: $ 107.52万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04261102/
• 关键词: Genome analysis; Sequence analysis; Structure-function relationship; Database; Network

The Scientific Research Project on the Priority Area "Genome Informatics" aimed at developing new computational technologies for genome research on human and other organisms. Especially, the project focused on (i) the database problem of how to organize and integrate different types of data being produced by genome analyzes and (ii) the computational problem of how to decipher biological meaning encoded in the sequence data which is the final product by experiments. During the five year period, we published more than 100 original papers in addition to the three volumes of the Genome Informatics Series Proceedings. We also published a number of original and review papers, ducuments, pamphlets, and books in Japanese. The project has been instrumental in establishing the GenomeNet computer network as the informatics infrastructure for biomedical research in Japan and in nurturing the bioinformatics research community by regularly organizing workshops and tutorials. The basic research results, especially for the database problem, have been implemented as practical databases and software products that are internationally made available as a part of the GenomeNet database service.

关于优先领域“基因组信息学”的科学研究项目旨在为人类和其他生物体的基因组研究开发新的计算技术。特别是，该项目集中在（i）如何组织和整合基因组分析产生的不同类型的数据的数据库问题和（ii）如何破译作为实验最终产品的序列数据中编码的生物学意义的计算问题。在五年的时间里，除了三卷《基因组信息学系列论文集》外，我们还发表了100多篇原创论文。我们还出版了许多日文的原创和评论论文、文件、小册子和书籍。该项目有助于建立GenomeNet计算机网络，作为日本生物医学研究的信息学基础设施，并通过定期举办讲习班和辅导班，培养生物信息学研究界。基础研究成果，特别是关于数据库问题的研究成果，已作为实用数据库和软件产品在国际上作为GenomeNet数据库服务的一部分提供。

项目成果

Hagiya,M.,Miyano,S.,Nakai,K.,Suyama,A.,Yokomori,T.,Takagi,T.: "Proceedings of Genome Informatics Workshop 1995" Universal Academy Press,Inc., 179 (1995)

Hagiya,M.、Miyano,S.、Nakai,K.、Suyama,A.、Yokomori,T.、Takagi,T.：“1995 年基因组信息学研讨会论文集”Universal Academy Press, Inc.，179（1995）

Ishikawa,M.,Toya,T.,Hoshida,M.,Nitta,K.,Ogiwara,A.,Kanehisa,M.: "Multiple sequence alignment by parallel simulated annealing." CABIOS. 9. 267-273 (1993)

Ishikawa,M.、Toya,T.、Hoshida,M.、Nitta,K.、Ogiwara,A.、Kanehisa,M.：“通过并行模拟退火进行多序列比对。”

Ogata,H.,Akiyama,Y.,Kanehisa,M.: "A genetic algorithm based molecular modeling technique for RNA stem-loop structures." Nucleic Acids Res.23. 419-426 (1995)

Ogata,H.、Akiyama,Y.、Kanehisa,M.：“基于遗传算法的 RNA 茎环结构分子建模技术。”

Tomii,K.,Kanehisa,M.: "Analysis of amino acid indices and mutation matrices for sequence comparison and structure prediction of proteins." Protein Eng.(in press). (1996)

Tomii,K.,Kanehisa,M.：“用于蛋白质序列比较和结构预测的氨基酸指数和突变矩阵分析。”

Dohi,H.: "Gene View:Multi-langnage human gene mapping library with graphical user interface." Comput.Appl.Biosci. 9. (1993)

Dohi,H.：“Gene View：具有图形用户界面的多语言人类基因图谱库。”