Backbone Database for Understanding the Biological Systems

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We have expanded KEGG, an integrated database resource for understanding higher-level systemic functions and utilities of the cell, the organism, and the ecosystem from genomic and metagenomic information. Specifically, we have developed the genome annotation methods to predict molecular networks from genome sequences for deciphering the biological systems and the chemical annotation methods to predict chemical reactions from chemical compound structures for uncovering microbial degradation pathways of environmental compounds and biosynthetic pathways of plant secondary metabolites.