Improving the efficiency of bovine oocyte maturation in vitro

提高牛卵母细胞体外成熟效率

• 批准号: LP0562536
• 负责人: Prof Robert Gilchrist
• 金额: $ 8.26万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-12-22 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0562536
• 关键词: Improving; efficiency; bovine; oocyte; maturation

For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to mature cow oocytes in vitro by altering the chemical composition of maturation medium, thus improving the efficiency of laboratory embryo production and related technologies.

对于乳制品和牛肉行业来说，高价值奶牛卵巢中数以百计的卵子（卵母细胞）无法怀孕是一种浪费的遗传资源。解锁这一资源的关键技术是卵母细胞的体外成熟，但这一过程效率低下。一个可能的原因是，目前体外成熟卵母细胞的方法不能充分模拟体内的自然过程。我们将设计新的系统，通过改变成熟培养基的化学成分，使奶牛卵母细胞在体外成熟，从而提高实验室胚胎生产的效率和相关技术。