"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Transgenerational Effects of Man-made Environmental Toxic Agents Contaminating the Earth-

《人地系统：实现人类社会与地球和谐相处的科学途径》-人造环境有毒物质污染地球的跨代效应-

• 批准号: 05278114
• 负责人: NOMURA Taisei
• 金额: $ 73.92万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05278114/
• 关键词: Man-made Toxic Agents; Transgenerational Effects; Damage in the reproductive system; Maldevelopment; Molecular Changes; Functional Defects; Radionucides; Transmission to descendants; チェルノブイリ放射能汚染の遺伝的影響; 精子・卵子障害; 染色体異常; 発生異常; 機能的障害

We focus the followings to examine the transgenerational effects of man-made toxic agents contaminating our planet :a) Morphological and functional abnormalities were induced in the offspring of mice, rats, and fish exposed to man-made toxic agents such as dioxin and glyphosate.b) Phthalate gives damage to erythrocytes, and then kills sperm by anoxia. Dioxin may injure the seminal vesicle preceeding the damage to germ cells.c) Repetitive sequence probe Pc-3 was cloned to detect anomalous polymorphism in the offspring of mice exposed to radiation.d) Ecological and genetic studies of radionuclides after Chernobyl catastrophe : Strong biological concentration of radionuclides was observed in mushroom, berries, etc. Genetic effects were detected in human in addition to wild and experimental animals (e.g., frog, Drosophila).

我们重点研究了污染我们星球的人造有毒物质的跨代影响：a）暴露于二恶英和草甘膦等人造有毒物质的小鼠、大鼠和鱼类的后代中诱导了形态和功能异常。B）邻苯二甲酸酯破坏红细胞，然后通过缺氧杀死精子。二恶英可能在损害生殖细胞之前损害精囊。c）克隆重复序列探针Pc-3，以检测受辐射小鼠后代的异常多态性。d）切尔诺贝利灾难后放射性核素的生态和遗传研究：在蘑菇、浆果、除了野生动物和实验动物（例如，青蛙，果蝇）。

项目成果

Fujino,Y., et al.: "Low senstivity of adrenal chromaffin cells to acetylcholine,neostigmine and oxotremorine in 21-day-old rats." Jpn.J.Pharmacol.3. 157-163 (1997)

Fujino,Y., et al.：“21 日龄大鼠的肾上腺嗜铬细胞对乙酰胆碱、新斯的明和氧化震颤素的敏感性较低。”

Nakaki,T., et al.: "Nitric oxide and neurodegenerative diseases." Current Topics Pharmacol.3. 157-163 (1997)

Nakaki,T. 等人：“一氧化氮和神经退行性疾病。”

藤井,儔子: "Wister今道およびF344/DuCrjラットにおける除草剤グルホシネート・アンモニウムの継世代的影響" 環境科学会誌. 9. 92-94 (1996)

Fujii, Yuko：“除草剂草铵膦对 Wister Imamichi 和 F344/DuCrj 大鼠的跨代影响”环境科学学会杂志 9. 92-94 (1996)。

Tanaka,T.: "The scid mutation in mice couses defects in the repair system for both double-strand DNA breaks and DNA-cross links." Mutation Research. 288. 277-280 (1993)

Tanaka,T.：“小鼠的 scid 突变会导致双链 DNA 断裂和 DNA 交联修复系统出现缺陷。”

Man-Earth Project Member: "1997 Research Results Report"141 (1998)

人地计划成员：《1997年研究成果报告》141（1998）