"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Transgenerational Effects of Man-made Environmental Toxic Agents Contaminating the Earth-
"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Transgenerational Effects of Man-made Environmental Toxic Agents Contaminating the Earth-
批准号:
05278114
负责人:
NOMURA Taisei
金额:
$73.92万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1997
中文摘要
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英文摘要
We focus the followings to examine the transgenerational effects of man-made toxic agents contaminating our planet :a) Morphological and functional abnormalities were induced in the offspring of mice, rats, and fish exposed to man-made toxic agents such as dioxin and glyphosate.b) Phthalate gives damage to erythrocytes, and then kills sperm by anoxia. Dioxin may injure the seminal vesicle preceeding the damage to germ cells.c) Repetitive sequence probe Pc-3 was cloned to detect anomalous polymorphism in the offspring of mice exposed to radiation.d) Ecological and genetic studies of radionuclides after Chernobyl catastrophe : Strong biological concentration of radionuclides was observed in mushroom, berries, etc. Genetic effects were detected in human in addition to wild and experimental animals (e.g., frog, Drosophila).
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Fujino,Y., et al.: "Low senstivity of adrenal chromaffin cells to acetylcholine,neostigmine and oxotremorine in 21-day-old rats." Jpn.J.Pharmacol.3. 157-163 (1997)
Fujino,Y., et al.:“21 日龄大鼠的肾上腺嗜铬细胞对乙酰胆碱、新斯的明和氧化震颤素的敏感性较低。”
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Nakaki,T., et al.: "Nitric oxide and neurodegenerative diseases." Current Topics Pharmacol.3. 157-163 (1997)
Nakaki,T. 等人:“一氧化氮和神经退行性疾病。”
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藤井,儔子: "Wister今道およびF344/DuCrjラットにおける除草剤グルホシネート・アンモニウムの継世代的影響" 環境科学会誌. 9. 92-94 (1996)
Fujii, Yuko:“除草剂草铵膦对 Wister Imamichi 和 F344/DuCrj 大鼠的跨代影响”环境科学学会杂志 9. 92-94 (1996)。
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Tanaka,T.: "The scid mutation in mice couses defects in the repair system for both double-strand DNA breaks and DNA-cross links." Mutation Research. 288. 277-280 (1993)
Tanaka,T.:“小鼠的 scid 突变会导致双链 DNA 断裂和 DNA 交联修复系统出现缺陷。”
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Nomura,T.,et al.: "Cytogenotoxicities of sublimed urethane gas to the mouse embryo" Mutat.Res.368. 59-64 (1996)
Nomura,T.,et al.:“升华聚氨酯气体对小鼠胚胎的细胞遗传毒性”Mutat.Res.368。
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共 99 条
Establishment of human benign prostatic hyperplasia model in super-SCID mice and its pathological analysis
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批准号:26670196
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2014
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负责人:NOMURA Taisei
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依托单位:
Direct effect of radiation and chemicals on human tissues and its mechanism
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批准号:23241023
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.45万
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财政年份:2011
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负责人:NOMURA Taisei
-
依托单位:
放射線、化学物質の継世代的(遺伝的)影響-マイクロサテライト突然変異誘発と疾病
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批准号:20241014
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.03万
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财政年份:2008
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负责人:NOMURA Taisei
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依托单位:
Development and analysis of human organ/tissue damage by fission radionuclides
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批准号:16201013
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.53万
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财政年份:2004
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负责人:NOMURA Taisei
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依托单位:
EFFECT OF RADIATION EXPOSURE ON HUMAN ORGAN/TISSUE AND I'TS EXPERIMENTAL PROTECTION AND THERAPY
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批准号:12308029
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$28.47万
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财政年份:2000
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负责人:NOMURA Taisei
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依托单位:
Genetic Effects of Low Dose Radiations in Man and Animals
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批准号:08041174
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$11.9万
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财政年份:1996
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负责人:NOMURA Taisei
-
依托单位:
Dose and dose rate effectiveness to determine the risk of low dose radiation to human
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批准号:07408031
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$6.85万
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财政年份:1995
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负责人:NOMURA Taisei
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依托单位:
Establishment of the system to study the function and therapy of deseases in human organs maintained in SCID mice
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批准号:07558078
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$8.0万
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财政年份:1995
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负责人:NOMURA Taisei
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依托单位:
Radiation (Low Dose) -induced Apoptosis and It's Susceptibility Genes
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批准号:04454606
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.1万
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财政年份:1992
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负责人:NOMURA Taisei
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依托单位:
Induction of Congenital Anomalies in the Progeny After Germ Cell Exposure to Radiation and Chemicals.
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批准号:63480506
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1988
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负责人:NOMURA Taisei
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依托单位:
Induction of in vivo somatic mutations by low dose radiation in mice -threshold and dose rate effects-.
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批准号:60480505
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.42万
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财政年份:1985
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负责人:NOMURA Taisei
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依托单位:
海外基金