Induction of Congenital Anomalies in the Progeny After Germ Cell Exposure to Radiation and Chemicals.

生殖细胞暴露于辐射和化学物质后诱导后代先天性异常。

基本信息

  • 批准号:
    63480506
  • 负责人:
  • 金额:
    $ 3.97万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
  • 财政年份:
    1988
  • 资助国家:
    日本
  • 起止时间:
    1988 至 1990
  • 项目状态:
    已结题

项目摘要

Radiation and chemicals are well known to produce visible and lethal mutations in higher plants and animal. Especially, extensive works have been done by specific loci method, etc. In mice, but large numbers of animals are necessary to test a variety of chemicals by these established methods. Recently, Nomura found that parental exposure to radiation can cause congenital malformations in the next generation in mice. Furthermore, induced malformations in F_1 offspring were similar to those found in humans. Experimental results obtained in the term of this project were summa-rized as follows.(1) Establishment of a method to detect germ-line mutation causing congenital malformation and its application to chemicals : Preconceptional treatment with ENU, DMBA and 4NQO as well as X-rays induced a significant incidence of congenital malformations in the F_1 offspring. In contrast to X-rays, spermatogonial stage was more sensitive to ENU than post-meiotic stages as it was in the specific locus mutation.(2) Detection of functional defects by germinal mutation : Parental exposure to ENU and X-rays caused a significant incidence of respiratory distress in F_1 fetuses, and a half of them were not accompanied with morphological malformations.(3) Heritability of induced malformations in the offspring : Dwarfism and tail anomalies inherited as a dominant trait with reduced expressivity.(4) Damage to fertilization capacity of the sperm : Very low doses of AS and LAS interrupted fertilization capacity of the human and mouse sperm to golden hamster eggs.(5) WHO recommendation : Germ-line alterations causing congenital malformation in F_1 offspring was adopted as a method to detect genetic hazards.(6) Future problems : Clinical and epidemiological survey should be performed. Functional defects will become more important in human population.
众所周知,辐射和化学物质会在高等动植物中产生可见的致命突变。特别是在小鼠身上,已经通过特定的位点方法等做了大量的工作,但用这些已建立的方法来检测各种化学物质需要大量的动物。最近,野村证券发现,父母暴露在辐射中会导致下一代小鼠先天性畸形。此外,在F_1代中发现的诱发畸形与人类相似。本项目的实验结果总结如下:(1)先天性畸形胚系突变检测方法的建立及其在化学制品中的应用:ENU、DMBA、4NQO和X射线孕前处理均可引起F_1代显著的先天性畸形发生率。与X射线相比,精原细胞阶段对ENU的敏感性高于减数分裂后阶段,因为它处于特定的基因突变。(2)生发突变检测功能缺陷:亲代暴露于ENU和X射线导致F_1胎儿呼吸窘迫的显著发生率,(4)精子受精能力的损害:极低剂量的AS和LAS干扰了人和小鼠精子对金黄地鼠卵的受精能力。(5)WHO建议:采用导致F_1代先天畸形的胚系改变作为检测遗传危险的方法。(6)未来问题:应进行临床和流行病学调查。功能缺陷在人类群体中将变得更加重要。

项目成果

期刊论文数量(72)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Nomura,T.: "Xーray and Chemically Induced Germーline Mutation Causing Phenotypical Anomalies in Mice." Mutation Res.198. 309-320 (1988)
Nomura, T.:“X 射线和化学诱导的种系突变导致小鼠表型异常”,198 年,第 309-320 页。
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    0
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Nomura,T.: "Suppression of developmental Anomalies by Maternal Macrophages in Mice." J.Exp.Med.172. 1325-1330 (1990)
Nomura,T.:“母体巨噬细胞抑制小鼠发育异常。”
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    0
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Nomura,T.: "An Examination of Respiratory distress and Chromosomal Abnormalities in the Offspring of Male Mice Treated with Ethylnitrosourea." Mutation Res.229. 115-112 (1990)
Nomura,T.:“用乙基亚硝基脲治疗的雄性小鼠后代的呼吸窘迫和染色体异常的检查。”
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    0
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Nomura, T.: "Perinatal and Multigeneration Carcinogenesis" IARC. 13 (1989)
Nomura, T.:“围产期和多代致癌作用”IARC。
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    0
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  • 通讯作者:
Nomura,T.: "Embryonic mutation as a possible cause of in utero carcinogenesis in mice revealed by postnatal treatment with 12-O-tetradecanoyl phorbol-13-acetate." Cancer Res.(1990)
Nomura,T.:“用 12-O-十四烷酰佛波醇-13-乙酸酯进行产后治疗揭示了胚胎突变是小鼠子宫内致癌的可能原因。”
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    0
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NOMURA Taisei其他文献

NOMURA Taisei的其他文献

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{{ truncateString('NOMURA Taisei', 18)}}的其他基金

Establishment of human benign prostatic hyperplasia model in super-SCID mice and its pathological analysis
人良性前列腺增生super-SCID小鼠模型的建立及病理分析
  • 批准号:
    26670196
  • 财政年份:
    2014
  • 资助金额:
    $ 3.97万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Direct effect of radiation and chemicals on human tissues and its mechanism
辐射和化学物质对人体组织的直接作用及其机制
  • 批准号:
    23241023
  • 财政年份:
    2011
  • 资助金额:
    $ 3.97万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
放射線、化学物質の継世代的(遺伝的)影響-マイクロサテライト突然変異誘発と疾病
辐射和化学物质的跨代(遗传)影响——微卫星突变和疾病
  • 批准号:
    20241014
  • 财政年份:
    2008
  • 资助金额:
    $ 3.97万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Development and analysis of human organ/tissue damage by fission radionuclides
裂变放射性核素对人体器官/组织损伤的发展和分析
  • 批准号:
    16201013
  • 财政年份:
    2004
  • 资助金额:
    $ 3.97万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
EFFECT OF RADIATION EXPOSURE ON HUMAN ORGAN/TISSUE AND I'TS EXPERIMENTAL PROTECTION AND THERAPY
辐射暴露对人体器官/组织及其实验保护和治疗的影响
  • 批准号:
    12308029
  • 财政年份:
    2000
  • 资助金额:
    $ 3.97万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Genetic Effects of Low Dose Radiations in Man and Animals
低剂量辐射对人和动物的遗传效应
  • 批准号:
    08041174
  • 财政年份:
    1996
  • 资助金额:
    $ 3.97万
  • 项目类别:
    Grant-in-Aid for international Scientific Research
Dose and dose rate effectiveness to determine the risk of low dose radiation to human
确定低剂量辐射对人体风险的剂量和剂量率有效性
  • 批准号:
    07408031
  • 财政年份:
    1995
  • 资助金额:
    $ 3.97万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Establishment of the system to study the function and therapy of deseases in human organs maintained in SCID mice
SCID小鼠人体器官功能及疾病治疗研究体系的建立
  • 批准号:
    07558078
  • 财政年份:
    1995
  • 资助金额:
    $ 3.97万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Transgenerational Effects of Man-made Environmental Toxic Agents Contaminating the Earth-
《人地系统:实现人类社会与地球和谐相处的科学途径》-人造环境有毒物质污染地球的跨代效应-
  • 批准号:
    05278114
  • 财政年份:
    1993
  • 资助金额:
    $ 3.97万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
Radiation (Low Dose) -induced Apoptosis and It's Susceptibility Genes
辐射(低剂量)诱导的细胞凋亡及其易感基因
  • 批准号:
    04454606
  • 财政年份:
    1992
  • 资助金额:
    $ 3.97万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)

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