Microfluidic Active-Feedback THz Biosensor for Direct, Sensitive and Selective Exosome and Virus Detection in Aqueous Environments (“MATISSE”)

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This interdisciplinary project aims to integrate the fundamental biochemical, biomedical, microfluidic, metamaterial-sensorics and active circuit design expertise of the project partners, to open up a venue of possibilities in the field of THz biosensing research. This novel approach will bring about a widely applicable integrated THz system for direct, sensitive and selective real-world biomedical routine measurement in native solutions into tangible proximity. The approach will enable for the first time the dynamic on-line analysis of vesicular structures, i.e. of exosomes and viruses, in aqueous solutions at pathophysiological density levels, in order to gain insights into fundamental biochemical correlations and causes of disease. The integration of an active-feedback power amplifier with a biochemically functionalized resonant sensing component into a microfluidic flow cell will enable the milestone of direct THz bioanalyte detection in aqueous solutions at physiologically relevant detection levels. The main objectives of the INTEREST priority program are reflected in the ambitions of the proposed project to open unexplored possibilities in THz research by interconnecting the diverse technological disciplines of integrated analogue circuit design, metamaterial-based physical principles and advanced bioanalytics to fathom into a fundamentally new generation of active microfluidic sensorics.