Investigation of the role of the fibrinolytic system in isehemic diseases
Investigation of the role of the fibrinolytic system in isehemic diseases
批准号:
14570649
负责人:
KOZAWA Osamu
金额:
$2.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2003
中文摘要
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英文摘要
We investigated the role of fibrinolyitc system in ischemic diseases. We obtained the results as follows:1.Lack of α2-antiplasmin decreases survival ratio after acute myocardial infarction. This phenomenon is due to mainly to the alteration of vascular permeability via an over-release of vascular endothelial growth factor (VEGF) as a result of the exaggerated activity of plasmin no longer tempered by α2 -antiplasmin.2.Lack of α2-antiplasmin improves the vascular patency after endothelial injury which is mainly because of the enhancement of endothelial cell healing via an over-release of VEGF.
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Takei M, Matsuno H, Okada K, Ueshima S, Matsuo O, Kozawa O: "Lack of α2-antiplasmin enhances ADP induced platelet micro-aggregation through the presence of excess active plasmin in mice."J.Thromb.Thrombolys. 14. 205-211 (2002)
Takei M、Matsuno H、Okada K、Ueshima S、Matsuo O、Kozawa O:“缺乏 α2-抗纤溶酶会通过小鼠体内过量的活性纤溶酶增强 ADP 诱导的血小板微聚集。”J.Thromb.Thrombolys 14。 205-211 (2002)
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作者:
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通讯作者:
Matsuno H, Kozawa O, Yoshimi N, Akamatsu S, Hara A, Mori H, Okada K, Matsuo O, Uematsu T: "Lack of α2-antiplasmin promotes pulmonary heart failure via over-release of VEGF after acute myocardial infarction"Blood. 100. 2487-2493 (2002)
Matsuno H、Kozawa O、Yoshimi N、Akamatsu S、Hara A、Mori H、Okada K、Matsuo O、Uematsu T:“急性心肌梗死后缺乏 α2-抗纤溶酶通过 VEGF 过度释放促进肺心力衰竭”血液。 100. 2487-2493 (2002)
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通讯作者:
Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuo O, Uematsu T.: "Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice."J.Cardiovasc.Pharmacol.. 39. 278-286 (2002)
Matsuno H、Kozawa O、Okada K、Ueshima S、Matsuo O、Uematsu T.:“纤溶成分的抑制剂在小鼠动脉血栓的形成和清除中发挥不同的作用。”J.Cardiovasc.Pharmacol.. 39. 278-
DOI:
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发表时间:
期刊:
影响因子:
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作者:
[]
通讯作者:
Takei M, Matsuno H, Okada K, Ueshima S, Matsuo O, Kozawa O.: "Lack of α2-antiplasmin enhances ADP induced platelet micro-aggregation through the presence of excess active plasmin in mice."J.Thromb.Thrombolysis. 14. 205-211 (2002)
Takei M、Matsuno H、Okada K、Ueshima S、Matsuo O、Kozawa O.:“缺乏 α2-抗纤溶酶会通过小鼠体内过量的活性纤溶酶增强 ADP 诱导的血小板微聚集。”J.Thromb.Thrombolysis 14。 .205-211 (2002)
DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuo O, Uematsu T: "Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice"J. Cardiovasc. Pharmacol.. 39. 278-286 (2002)
Matsuno H、Kozawa O、Okada K、Ueshima S、Matsuo O、Uematsu T:“纤溶成分的抑制剂在小鼠动脉血栓的形成和清除中发挥不同的作用”J。
DOI:
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作者:
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通讯作者:
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