Investigation of the role of the fibrinolytic system in isehemic diseases

纤溶系统在缺血性疾病中作用的研究

• 批准号: 14570649
• 负责人: KOZAWA Osamu
• 金额: $ 2.24万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570649/
• 关键词: acute coronary syndrome; fibrinolytic system; α2-antiplasmin; vascular endothelial growth factor; 肺性心

We investigated the role of fibrinolyitc system in ischemic diseases. We obtained the results as follows:1.Lack of α2-antiplasmin decreases survival ratio after acute myocardial infarction. This phenomenon is due to mainly to the alteration of vascular permeability via an over-release of vascular endothelial growth factor (VEGF) as a result of the exaggerated activity of plasmin no longer tempered by α2 -antiplasmin.2.Lack of α2-antiplasmin improves the vascular patency after endothelial injury which is mainly because of the enhancement of endothelial cell healing via an over-release of VEGF.

我们研究了纤溶系统在缺血性疾病中的作用。我们得到的结果如下：1。α - 2抗纤溶酶缺乏降低急性心肌梗死后生存率。这种现象主要是由于α2 -抗纤溶酶无法调节的纤溶酶活性过高，导致血管内皮生长因子（VEGF）过度释放，从而改变了血管通透性。缺乏α2-抗纤溶酶可改善内皮细胞损伤后的血管通畅，这主要是通过过度释放VEGF促进内皮细胞愈合。

项目成果

Takei M, Matsuno H, Okada K, Ueshima S, Matsuo O, Kozawa O: "Lack of α2-antiplasmin enhances ADP induced platelet micro-aggregation through the presence of excess active plasmin in mice."J.Thromb.Thrombolys. 14. 205-211 (2002)

Takei M、Matsuno H、Okada K、Ueshima S、Matsuo O、Kozawa O：“缺乏 α2-抗纤溶酶会通过小鼠体内过量的活性纤溶酶增强 ADP 诱导的血小板微聚集。”J.Thromb.Thrombolys 14。 205-211 (2002)

Matsuno H, Kozawa O, Yoshimi N, Akamatsu S, Hara A, Mori H, Okada K, Matsuo O, Uematsu T: "Lack of α2-antiplasmin promotes pulmonary heart failure via over-release of VEGF after acute myocardial infarction"Blood. 100. 2487-2493 (2002)

Matsuno H、Kozawa O、Yoshimi N、Akamatsu S、Hara A、Mori H、Okada K、Matsuo O、Uematsu T：“急性心肌梗死后缺乏 α2-抗纤溶酶通过 VEGF 过度释放促进肺心力衰竭”血液。 100. 2487-2493 (2002)

Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuo O, Uematsu T.: "Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice."J.Cardiovasc.Pharmacol.. 39. 278-286 (2002)

Matsuno H、Kozawa O、Okada K、Ueshima S、Matsuo O、Uematsu T.：“纤溶成分的抑制剂在小鼠动脉血栓的形成和清除中发挥不同的作用。”J.Cardiovasc.Pharmacol.. 39. 278-

Takei M, Matsuno H, Okada K, Ueshima S, Matsuo O, Kozawa O.: "Lack of α2-antiplasmin enhances ADP induced platelet micro-aggregation through the presence of excess active plasmin in mice."J.Thromb.Thrombolysis. 14. 205-211 (2002)

Takei M、Matsuno H、Okada K、Ueshima S、Matsuo O、Kozawa O.：“缺乏 α2-抗纤溶酶会通过小鼠体内过量的活性纤溶酶增强 ADP 诱导的血小板微聚集。”J.Thromb.Thrombolysis 14。 .205-211 (2002)

Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuo O, Uematsu T: "Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice"J. Cardiovasc. Pharmacol.. 39. 278-286 (2002)

Matsuno H、Kozawa O、Okada K、Ueshima S、Matsuo O、Uematsu T：“纤溶成分的抑制剂在小鼠动脉血栓的形成和清除中发挥不同的作用”J。