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Central nervous system modulates pain induced by orthodontic tooth movement

中枢神经系统调节正畸牙齿移动引起的疼痛

基本信息

批准号：
14571948
负责人：
YAMASHIRO Takashi
金额：
$ 2.56万
依托单位：
OKAYAMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571948/
关键词：
tooth movement pain modulation opioid peptide enkephalin serotonergic inhibitory system antinociception

项目摘要

Orthodontic tooth movement causes pain and discomfort to patients. Pain information is transmitted via an ascending pain pathway from the peripheral tissues to the central nervous system. In addition, there is also a descending pathway that allows the brain to modulate pain sensation. Endogenous pain control system involves multiple pathways, and multiple endogenous opioid peptides are released in both spinal and supraspinal levels and produce analgesia. However it is not clearly whether experimental tooth movement activates endogenous enkephalinergic system. To investigate the possible involvement of this system during experimental tooth movement, we analyzed possible deviation of Preproenkephalin (PPE) mRNA expression pattern by using in situ hybridization.In this study, the experimental tooth movement upregulates PPE mRNA only in the dorsomedial part of the superficial layer of Vc. Furthermore, this upregulation of the expression was confirmed only in the ipsilateral side in contrast to that of control rats. The resent findings together with previous ones showed that endogenous enkephalinergic systems were activated presumably by the nociception caused by the experimental tooth movement. Nociceptive somatic stimuli also activate descending monoaminergic pathways, which modulate the transmission of ascending sensory messages, and monoaminergic neurons projecting to the dorsal spinal cord are critical to the regulation of transmission of nociceptive information. It is known that nociception induced by experimental tooth movement activates the endogenous descending serotonergic system Recent study showed S-HT up regulates the PPE mRNA expression in the cultured spinal cord. Taken, together, in the antinociception mechanism during experimental tooth movement, serotonergic descending systems exert their inhibitory roles by activating the PPE gene and c-fos is associated with this serotonergic regulation of that endogenous opioid ligand genes.

正畸牙齿移动会给患者带来疼痛和不适。疼痛信息通过上行疼痛通路从周围组织传递到中枢神经系统。此外，还有一条下行通路可以让大脑调节痛觉。内源性疼痛控制系统涉及多个途径，多种内源性阿片肽在脊髓和脊髓上水平释放并产生镇痛。然而，尚不清楚实验性牙齿移动是否激活内源性脑啡肽系统。为了探讨该系统在实验性牙齿移动过程中可能的参与，我们利用原位杂交分析了前脑啡肽（PPE）mRNA表达模式可能存在的偏差。在本研究中，实验性牙齿移动仅在Vc表层的背内侧部分上调PPE mRNA。此外，与对照大鼠相比，这种表达上调仅在同侧得到证实。最近的研究结果与之前的研究结果一起表明，内源性脑啡肽能系统可能是由实验性牙齿移动引起的伤害感受激活的。伤害性躯体刺激还会激活下行单胺能通路，调节上行感觉信息的传递，而投射到背侧脊髓的单胺能神经元对于伤害性信息传递的调节至关重要。众所周知，实验性牙齿移动引起的伤害感受会激活内源性下降血清素系统。最近的研究表明，S-HT 上调培养脊髓中 PPE mRNA 的表达。综上所述，在实验性牙齿移动期间的抗伤害机制中，血清素能下行系统通过激活 PPE 基因发挥其抑制作用，而 c-fos 与内源性阿片配体基因的血清素能调节相关。