Influence of antioxidant capacity on arterial compliance

氧化型低密度脂蛋白(LDL)，如丙二醛修饰的低密度脂蛋白(MDA-LDL)，是由活性氧(ROS)作用产生的，在动脉粥样硬化的发生发展中起着重要作用。然而，还没有人证实人类血液中的抗氧化能力与动脉顺应性之间的关系。本研究旨在探讨低强度阻力训练对老年人抗氧化能力、血液脂蛋白水平及动脉顺应性指标的影响。17名男性和女性(60-81岁)参加了为期3个月的阻力训练计划，其中以1公斤哑铃练习为主，重复15-20次。所有受试者都没有明显的心血管疾病，通过病史问卷调查，血脂和脂蛋白浓度均在正常范围内。心脏-踝部脉搏波速度(心踝血管指数：CAVI，Fukuda VS-1000)作为动脉顺应性的指标被测量。尽管训练后血浆高密度脂蛋白胆固醇浓度显著升高(p&lt；0.05)，但作为动脉硬化指数的T-C/高密度脂蛋白胆固醇的值并没有明显改善。作为氧化应激指标的血浆MDA-LDL和8-OHdG浓度在训练后呈下降趋势，其中8-OHdG浓度较训练前显著下降(p&lt；0.05)。另一方面，训练后血浆辅酶Q10浓度显著升高。低强度耐力训练提高了辅酶Q10系统等抗氧化能力，降低了血浆氧化应激水平，但不影响动脉顺应性。

Oxidized low-density lipoprotein(LDL) such as malondialdehyde-modified LDL(MDA-LDL) is generated by the action of reactive oxygen species(ROS) and believed to play a critical role in the development and progression of atherosclerosis. However, no one has confirmed the relationship between antioxidant capacity in human blood and the arterialcompliance. The purpose of this study was to investigate the effects of the low-intensity resistance training on antioxidant capacity, lipoprotein levels in the blood, and an index of arterial compliance in elderly people.Seventeen males and females (60-81 years) participated in a resistance-training program for 3 months consisting of a set of mainly dumbbell exercises using the 1-kg dumbbell with 15-20 repetitions. All subjects were free of overt cardiovascular disease as assessed by medical history questionnaire and had plasma lipid and lipoprotein concentrations all within the normal range. The pulse wave velocity between heart and ankle (cardio ankle vascular index : CAVI, Fukuda vs-1000) was measured as an index of arterial compliance.Although plasma HDL-C concentrations were significantly increased (p<0.05) after the training, the value of T-C/HDL-C as an index of arteriosclerosis index did not improve significantly. Plasma MDA-LDL and 8-OhdG concentrations as index oxidative stress showed a tendency to decrease after the training, and a significant (p<0.05) decreases were observed, in 8-OhdG concentrations compared to the pre training levels. On the other hand, the concentrations coenzyme Q10 in the plasma increased significantly after the training. The levels of CAVI also showed a tendency to decrease after the training, however, there was no significant changes.These results suggest that the low-intensity resistance training increased antioxidant capacity such as coenzyme Q10 system and decreased the oxidative stress in the plasma, but did not influence the arterial compliance.