Transcriptionaland translational regulation of peptide factors for the growth and differentiation of gastrointestinal epithelial cells
Transcriptionaland translational regulation of peptide factors for the growth and differentiation of gastrointestinal epithelial cells
批准号:
20590382
负责人:
ITOH Hiroshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
MicroRNA (miRNA) expression pattern and target mRNAs of squamous cell carcinoma (SCC) are different from those of other organ's malignancies. MiR-205 might be a specific marker miRNA of both normal and malignant squamous epithelia, while miR-21 might be a putative oncogenic miRNA in SCC. In addition, several miRNAs including miR-200c and miR-27b are down-regulated by HGF stimulation. These miRNAs might play an important role for the translation of HGF downstream functional molecules.
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Expression of microRNAs in squamous cell carcinoma of human head and neck(HNSCC)and the esophagus(ESCC)and their regulation by hepatocyte growth factor
microRNA在人头颈鳞状细胞癌(HNSCC)和食管癌(ESCC)中的表达及其肝细胞生长因子的调控
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kimura S, Naganuma S, Susuki D, Hirono Y, Yamaguchi A, Fujieda S, Sano K, Itoh H]
通讯作者:
Itoh H
頭頚部扁平上皮癌細胞株におけるHGF によるマイクロRNA 発現調節
HGF对头颈鳞状细胞癌细胞系中microRNA表达的调控
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[鈴木弟, 長沼誠二, 木村相泰, 喜多村直実, 藤枝重治, 伊藤浩史]
通讯作者:
伊藤浩史
Expression of microRNAs in squamous cell carcinoma of human head and neck (HNSCC))and the esophagus (ESCC)
microRNA在人头颈鳞状细胞癌(HNSCC)和食管癌(ESCC)中的表达
DOI:
--
发表时间:
2010
期刊:
miR-205 and miR-21are specific markers for HNSCC and ESCC、Oncol.Rep. 23
影响因子:
--
作者:
[Kimura S, Naganuma S, Susuki D, Hirono Y, Yamaguchi A, Fujieda S, Sano K, Itoh H]
通讯作者:
Itoh H
HGF刺激による大腸癌細胞株の形態変化に関与するmiRNAの発現変動
HGF刺激诱导的结直肠癌细胞系形态变化中miRNA表达的变化
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[長沼誠二, 鈴木弟, 木村相泰, 喜多村直実, 伊藤浩史]
通讯作者:
伊藤浩史
Expression of hepatocyte growth factor act ivator type 1 on the epithelial cell surface is regulated by hypoxic and oxidative stresses.
上皮细胞表面 1 型肝细胞生长因子激活剂的表达受到缺氧和氧化应激的调节。
DOI:
--
发表时间:
2008
期刊:
Virchows Arch. 453
影响因子:
--
作者:
[Komaki W, Fukushima T, Tanaka H, Itoh H, Chosa E, Kataoka H]
通讯作者:
Kataoka H
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