Effects of physical stimulations on regeneration of peripheral nerves and denervated muscle fibers

物理刺激对周围神经和失神经肌纤维再生的影响

• 批准号: 16500342
• 负责人: MIKI Akinori
• 金额: $ 2.24万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16500342/
• 关键词: electromagnetic stimulation; electrical stimulation; ultrasound stimulation; nerve regeneration; muscle regeneration; wound healing; 末梢神経; 再生; 脱神経; 骨格筋; 物理刺激; 物理療法; 関節可動域運動; 廃用性筋萎縮; マウス坐骨神経; 免疫組織化学

Effects of physical stimulations (electromagnetic stimulation, electric stimulation, ultrasound stimulation, stretch) on nerve and muscle regeneration and wound healing were morphologically and immunohistochemically investigated1.Effects of physical stimulation on wound healing were morphologically studied in the injured mouse skin. Our findings suggest that ultrasound stimulation and electromagnetic stimulation promote the wound healing, but leaser irradiation was not effective.2.When the stretch was applied soon after the eccentric exercise, muscle swelling and secondary degeneration at the injury site were lightened and muscle regeneration was promoted It has been said that one of the reasons for delayed onset muscle soreness (DOMS) might be the swelling of muscles occurring one or two days after the extensive exercise. The findings of the present study suggest that adequate stretch soon after the exercise might be useful to reduce the DOMS.3.It has been widely accepted that electrical and electromagnetic stimulation promotes peripheral nerve regeneration, and also that macrophages and Schwann cells play important role for nerve regeneration. In the present study, influence of electromagnetic stimulation on expression of nerve growth factor (NGF) in the injured sciatic nerve was immunohistochemically investigated. When the electromagnetic stimulation was applied one day after the injury, expression of NGF at the injury site increased. Electron microscopically, immunoreaction for NGF was detected in the cytoplasm of Schwann cell and fibroblasts and along the basal lamina of Schwann cells.

从形态学和免疫组化两方面研究了物理刺激（电磁刺激、电刺激、超声刺激、牵拉）对神经和肌肉再生及创面愈合的影响1.从形态学角度研究了物理刺激对小鼠皮肤损伤创面愈合的影响。实验结果表明，超声刺激和电磁波刺激能促进创面愈合，激光照射对创面愈合无明显影响。减轻了损伤部位的肌肉肿胀和继发性变性，促进了肌肉再生。可能是肌肉肿胀发生在一个或两个大的运动后的天。本研究结果提示，运动后立即进行适当的牵张运动可能有助于减少DOMS。3.电刺激和电磁刺激促进周围神经再生已被广泛接受，巨噬细胞和雪旺细胞在神经再生中起重要作用。本研究采用电化学方法观察了电磁刺激对坐骨神经损伤后神经生长因子（NGF）表达的影响。伤后1d给予电磁刺激，损伤部位神经生长因子表达增加。电镜下，神经生长因子免疫反应主要分布于雪旺细胞和成纤维细胞的胞浆内，并沿雪旺细胞的基底板沿着分布。

项目成果

皮膚組織修復における物理療法の有効性

物理疗法在皮肤组织修复中的有效性

• 发表时间: 2004
• 期刊: 理学療法 21巻11号
• 作者: Shinohara H;Ogata A;Miki A;篠原英記
• 通讯作者: 篠原英記

Repairing process in the transected muscle fibers of the mouse tibialis anterior.

小鼠胫骨前肌横切肌纤维的修复过程。

• 发表时间: 2006
• 期刊: JJPTA 9(印刷中)
• 作者: T.Saito;N.Suzuki;A.Hattori;S.Suzuki;M.Hayashibe;Y.Otake;A.Uchiyama;Yamamoto D;Tasaki H;Fujita N;松原貴子;松原貴子;藤田直人;藤本太郎;大鶴直史;Matsumoto M
• 通讯作者: Matsumoto M

Effects of stretch on muscle regeneration in the damaged mouse soleus muscle after eccentric exercise.

拉伸对偏心运动后受损小鼠比目鱼肌再生的影响。

• 发表时间: 2005
• 期刊: Bull Allied Med Sci Kobe 22(印刷中)
• 作者: T.Saito;N.Suzuki;A.Hattori;S.Suzuki;M.Hayashibe;Y.Otake;A.Uchiyama;Yamamoto D;Tasaki H;Fujita N;松原貴子;松原貴子;藤田直人;藤本太郎;大鶴直史;Matsumoto M;Tasaki H;田崎洋光;村上恵津子;Matsumoto M;Matsubara T
• 通讯作者: Matsubara T

皮膚組織修復における物理刺激の有効性

物理刺激在皮肤组织修复中的有效性

• 发表时间: 2004
• 期刊: 理学療法 21・11
• 作者: 篠原英記;小形晶子;三木明徳
• 通讯作者: 三木明徳

Effects of physical stimulation on wound healing in the injured mouse skin (in Japanese)

物理刺激对小鼠受伤皮肤伤口愈合的影响（日语）

• 发表时间: 2004
• 期刊: Rigakuryouhou 21(11)
• 作者: Shinohara H;Ogata A;Miki A
• 通讯作者: Miki A