Reconsideration of physical approach for skeletal muscle injury

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Influence of icing and heating on muscle regeneration after the crush injury to skeletal muscle was morphologically, histochemically and biochemically examined. Due to the icing, muscle regeneration was suppressed and excessive accumulation of collagen fibers occurred. In contrast, owing to the heating, muscle regeneration was accelerated and accumulation of collagen fibers was suppressed. To know the difference in mechanisms of atrophy in the denervated and unloaded muscles, expression of proteolytic activity was biochemically examined. Atrophy in the denervated muscle was severer than that in the unloaded muscle,and the expression of proteolytic activity in the former was higher than that in the latter. The electric stimulation could partially attenuate atrophy in the denervatedmuscle, but not in the unloaded muscle.