权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Deep observational researches regarding the profound structures, morphogenesis and regeneration of nerves, bloods and muscles existing in the visceral internal organs as well as four limbs, using sui genesis technology of whole-mount staining, and molecul

利用整体染色、分子生物学等独特成因技术，对内脏、四肢等神经、血液、肌肉的深层结构、形态发生和再生进行深入观察研究

基本信息

批准号：
16590139
负责人：
TANAKA Shigenori
金额：
$ 2.24万
依托单位：
Graduate School of Medical Science, Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

Researches of elucidation of form and structure of the sympathetic nerve distributed in the heart, that is, cardiac nerves were furthermore promoted.The cardiac nerves were found to arise numerous in number from very broad areas of the sympathetic trunk, communicating each other very numerously.Furthermore, their patterns or forms of running were much more complicated than those of the cardiac branches of the vagus nerve.As a result, clarification of features of these cardiac nerves are difficult than the cardiac branches of the vagus nerve.Inter alia, human examples applicable for researches are exceedingly large as those of other vertebrate and further more, they communicate each other and their coursing figures are much more complicated than those of the cardiac branches of the vagus nerve. Therefore, the complete clarification of human cardiac nerves are difficult article.In order to resolve this difficulty, we applied new specific technology. Using this technology, we are able to … More grease alcohol by using alcohol, stain nerves with arizarin red S, and to elucidate blood vessels in all experimental examples of humans and other vertebrates.In consequence, the cardiac nerves were found to arise from the sympathetic trunk in a wide area from the cervical until the lowest thoracic level, i.e., ThI0 (and further more ThI2) in human examples.Furthermore, the three-dimensional structures of human cadavers have been clarified fundamentally not only from the human anatomical point of view, but also comprehensively from the vertebrate comparative anatomy and embryology.We have been made presentations of these results in academic conferences (the 8^<th> Meeting of Japanese Research Society of Clinical Anatomy and the 16^<th> Meeting of Japanese Research Society of Periphera Nerve).Therewithal, the contribution manuscripts of the international science magazine concerning the form of the cardiac nerves and branches are being to retouched and corrected.The clarification of morphology and morphogenesis of the cardiac nerves are performed by using methods for whole embryo immunity staining in muskrats which are nearer human's form than the mouse and the rat for the form formation (doctor's course student's submitting thesis).These results of this research were presented in the 110th in Japanese Anatomy Association. Contribution to the international science magazine is also being prepared. The form of generation of the muskrat liver, clinical medicine meaning (Endoclinology 2004 : Anat.Enbryol. 2004) has been clarified. Furthermore, figures of the nerves innervating the levator palate muscle and mandibular nerve were elucidated (Clin Anat 2004 ; Surg Radiol Anat 2004).At the moment, we make exertions to advancing researches in order to analyze the intimate structures as well as morphogenesis of arteries, veins and nerves coursing in the falciform and teres hepatic ligaments and to clarify the morphological as well as functional relationships-of lymphatic vessel around the xiphoid process with the live in the human cadavers and also in muskrats. These structures and root meanings of these structures are being clarified from the embryological and clinical viewpoints, building up co-operation with clinical researchers. We are also making collaborative researches with doctors in order to open up new method of measurement, diagnosis and treatment of abnormal bones, and also the molecular and histochemical researches of genesis of head and neck muscles. Less

对分布在心脏内的交感神经即心神经的形态结构的阐明的研究得到进一步的推进。发现心神经从交感干的很广的区域中大量地发出，彼此之间的联系非常多。而且，它们的走行方式或形式比迷走神经的心支复杂得多。结果，这些心脏神经的特征比迷走神经的心脏分支的特征更难阐明，阿利亚是，人类可用于研究的例子比其他脊椎动物的例子要多得多，而且它们相互沟通，它们的走行图形比迷走神经的心脏分支复杂得多。因此，完整阐明人体心脏神经是一个难点，为了解决这个难题，我们应用了新的特异性技术。利用这项技术，我们可以 ...更多信息通过使用酒精润滑酒精，用茜素红S染色神经，并在人类和其他脊椎动物的所有实验实例中阐明血管。结果，发现心神经在从颈部到最低胸部水平的广泛区域中从交感干发出，即，ThI 0（以及更多的ThI 2）。此外，不仅从人体解剖学的角度，而且从脊椎动物比较解剖学和胚胎学的角度，从根本上阐明了人尸体的三维结构。我们在学术会议上（<th>日本临床解剖学研究会第8次会议和日本神经研究会第16次会议）发表了这些结果。因此<th>，对国际科学杂志上有关心神经及其分支形态的稿件进行了修改和更正，并对形态形成上比小鼠和大鼠更接近人的麝鼠，采用全胚胎免疫染色方法，对心神经的形态和形态发生进行了澄清（博士生提交论文）本研究结果在日本解剖学会第110届会议上发表。还在准备向国际科学杂志投稿。麝鼠肝脏的发生形式，临床医学意义（Endoclinology 2004：Anat.Enbryol. 2004年，他澄清。并对支配腭提肌和下颌神经的神经进行了解剖学观察（《临床解剖学》，2004年; Surg Radiol Anat 2004）。目前，我们致力于推进研究，以分析动脉的内部结构以及形态发生，肝镰状韧带和肝圆韧带内的静脉和神经，并阐明其形态和功能关系。本文对人尸体和麝鼠尸体剑突周围淋巴管与肝脏的关系进行了研究。这些结构和这些结构的根本含义正在从胚胎学和临床的角度进行澄清，与临床研究人员建立合作。我们还与医生合作研究，以开辟新的测量方法，诊断和治疗异常骨骼，以及头颈部肌肉发生的分子和组织化学研究。少